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NEDD8 NEDD8 ubiquitin like modifier [ Homo sapiens (human) ]

Gene ID: 4738, updated on 5-Jul-2020

Summary

Official Symbol
NEDD8provided by HGNC
Official Full Name
NEDD8 ubiquitin like modifierprovided by HGNC
Primary source
HGNC:HGNC:7732
See related
Ensembl:ENSG00000129559 MIM:603171
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NEDD-8
Expression
Ubiquitous expression in fat (RPKM 81.8), kidney (RPKM 81.6) and 25 other tissues See more
Orthologs

Genomic context

See NEDD8 in Genome Data Viewer
Location:
14q12
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (24216857..24232367, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (24686057..24701576, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene charged multivesicular body protein 4A Neighboring gene Sharpr-MPRA regulatory region 5945 Neighboring gene NEDD8-MDP1 readthrough Neighboring gene magnesium dependent phosphatase 1 Neighboring gene Sharpr-MPRA regulatory region 3923 Neighboring gene guanosine monophosphate reductase 2 Neighboring gene TERF1 interacting nuclear factor 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 complexes with NEDD8 PubMed
vif HIV-1 Vif recruits an active ubiquitin ligase complex composed of Elongin B/C, Cullin5, Nedd8, and Rbx1, which mediates polyubiquitylation of APOBEC3G PubMed
Vpu vpu HIV-1 Vpu is identified to have a physical interaction with neural precursor cell expressed, developmentally down-regulated 8 (NEDD8) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ43224, MGC104393, MGC125896, MGC125897

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tag IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
anatomical structure morphogenesis TAS
Traceable Author Statement
more info
PubMed 
cellular iron ion homeostasis TAS
Traceable Author Statement
more info
 
cellular protein modification process TAS
Traceable Author Statement
more info
PubMed 
modification-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
post-translational protein modification TAS
Traceable Author Statement
more info
 
protein deubiquitination TAS
Traceable Author Statement
more info
 
protein localization IEA
Inferred from Electronic Annotation
more info
 
protein neddylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein neddylation IDA
Inferred from Direct Assay
more info
PubMed 
NOT protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination TAS
Traceable Author Statement
more info
 
proteolysis TAS
Traceable Author Statement
more info
PubMed 
regulation of proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-dependent protein catabolic process TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
NEDD8
Names
neddylin
neural precursor cell expressed, developmentally down-regulated 8
ubiquitin-like protein Nedd8

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006156.3NP_006147.1  NEDD8

    See identical proteins and their annotated locations for NP_006147.1

    Status: VALIDATED

    Source sequence(s)
    BC104200, BE548741, CF130271
    Consensus CDS
    CCDS9621.1
    UniProtKB/Swiss-Prot
    Q15843
    Related
    ENSP00000250495.5, ENST00000250495.10
    Conserved Domains (1) summary
    cd01806
    Location:376
    Ubl_NEDD8; ubiquitin-like (Ubl) domain found in neural precursor cell expressed developmentally down-regulated protein 8 (NEDD8) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    24216857..24232367 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_018654722.1 Reference GRCh38.p13 PATCHES

    Range
    517835..533345 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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