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RPL10A ribosomal protein L10a [ Homo sapiens (human) ]

Gene ID: 4736, updated on 27-Nov-2024

Summary

Official Symbol
RPL10Aprovided by HGNC
Official Full Name
ribosomal protein L10aprovided by HGNC
Primary source
HGNC:HGNC:10299
See related
Ensembl:ENSG00000198755 MIM:615660; AllianceGenome:HGNC:10299
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
uL1; L10A; CSA19; NEDD6; Csa-19
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L1P family of ribosomal proteins. It is located in the cytoplasm. The expression of this gene is downregulated in the thymus by cyclosporin-A (CsA), an immunosuppressive drug. Studies in mice have shown that the expression of the ribosomal protein L10a gene is downregulated in neural precursor cells during development. This gene previously was referred to as NEDD6 (neural precursor cell expressed, developmentally downregulated 6), but it has been renamed RPL10A (ribosomal protein 10a). As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 957.8), bone marrow (RPKM 440.0) and 25 other tissues See more
Orthologs
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Genomic context

See RPL10A in Genome Data Viewer
Location:
6p21.31
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (35468401..35470780)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (35291477..35293856)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (35436178..35438557)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene makorin ring finger protein 6, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17092 Neighboring gene FA complementation group E Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24405 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:35435944-35436500 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24406 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24407 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24408 Neighboring gene microRNA 7111 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:35447729-35448229 Neighboring gene TEA domain transcription factor 3 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:35453191-35453766 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:35454343-35454918 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:35456069-35456644 Neighboring gene VISTA enhancer hs1887 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:35463100-35463885 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17093 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:35464832-35465762 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:35465763-35466692 Neighboring gene uncharacterized LOC124901309 Neighboring gene TUB like protein 1 Neighboring gene MPRA-validated peak5766 silencer

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of ribosomal protein L10a (RPL10A) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
PubMed 
enables structural constituent of ribosome NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic translation IC
Inferred by Curator
more info
PubMed 
involved_in cytoplasmic translation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cytoplasmic translation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in response to ethanol IEA
Inferred from Electronic Annotation
more info
 
involved_in translation NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
large ribosomal subunit protein uL1
Names
60S ribosomal protein L10a
NEDD-6
neural precursor cell expressed developmentally down-regulated protein 6
NP_009035.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007104.5NP_009035.3  large ribosomal subunit protein uL1

    See identical proteins and their annotated locations for NP_009035.3

    Status: REVIEWED

    Source sequence(s)
    BC006791, BP318268
    Consensus CDS
    CCDS4806.1
    UniProtKB/Swiss-Prot
    B2R801, P52859, P53025, P62906, Q5TZT6, Q8J013
    UniProtKB/TrEMBL
    Q1JQ76
    Related
    ENSP00000363018.3, ENST00000322203.7
    Conserved Domains (1) summary
    cl00322
    Location:2217
    Ribosomal_L1; Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    35468401..35470780
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    35291477..35293856
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)