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NDUFB7 NADH:ubiquinone oxidoreductase subunit B7 [ Homo sapiens (human) ]

Gene ID: 4713, updated on 18-Aug-2020

Summary

Official Symbol
NDUFB7provided by HGNC
Official Full Name
NADH:ubiquinone oxidoreductase subunit B7provided by HGNC
Primary source
HGNC:HGNC:7702
See related
Ensembl:ENSG00000099795 MIM:603842
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B18; CI-B18
Summary
The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. It is located at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in fat (RPKM 29.3), heart (RPKM 25.7) and 25 other tissues See more
Orthologs

Genomic context

See NDUFB7 in Genome Data Viewer
Location:
19p13.12
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (14566078..14572066, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (14676890..14682889, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member B1 Neighboring gene microRNA 639 Neighboring gene trans-2,3-enoyl-CoA reductase Neighboring gene uncharacterized LOC112268253 Neighboring gene C-type lectin domain containing 17A Neighboring gene RNA, 7SL, cytoplasmic 337, pseudogene Neighboring gene RNA, 7SL, cytoplasmic 842, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7 (NDUFB7) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC2480

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NADH dehydrogenase (ubiquinone) activity NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial intermembrane space IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial respiratory chain complex I IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial respiratory chain complex I IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion HDA PubMed 

General protein information

Preferred Names
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7
Names
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa
NADH-ubiquinone oxidoreductase B18 subunit
cell adhesion protein SQM1
complex I B18 subunit
complex I-B18
NP_004137.2
XP_011526341.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004146.6NP_004137.2  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

    See identical proteins and their annotated locations for NP_004137.2

    Status: REVIEWED

    Source sequence(s)
    BC002595, CB124371
    Consensus CDS
    CCDS12314.1
    UniProtKB/Swiss-Prot
    P17568
    Related
    ENSP00000215565.1, ENST00000215565.3
    Conserved Domains (1) summary
    pfam05676
    Location:40100
    NDUF_B7; NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    14566078..14572066 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528039.3XP_011526341.1  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 isoform X1

    Conserved Domains (1) summary
    pfam05676
    Location:264
    NDUF_B7; NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7)
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