U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

NDUFB1 NADH:ubiquinone oxidoreductase subunit B1 [ Homo sapiens (human) ]

Gene ID: 4707, updated on 5-Aug-2022

Summary

Official Symbol
NDUFB1provided by HGNC
Official Full Name
NADH:ubiquinone oxidoreductase subunit B1provided by HGNC
Primary source
HGNC:HGNC:7695
See related
Ensembl:ENSG00000183648 MIM:603837; AllianceGenome:HGNC:7695
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MNLL; CI-MNLL; CI-SGDH
Summary
Involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrion and nuclear speck. Part of mitochondrial respiratory chain complex I. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney (RPKM 82.0), colon (RPKM 69.9) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See NDUFB1 in Genome Data Viewer
Location:
14q32.12
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (92116123..92121706, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (86345661..86351545, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (92582467..92588050, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903363 Neighboring gene ataxin 3 repeat instability region Neighboring gene ataxin 3 Neighboring gene cleavage and polyadenylation specific factor 2 Neighboring gene RNA, U6 small nuclear 366, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 is identified to have a physical interaction with NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1 (NDUFB1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

General protein information

Preferred Names
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1
Names
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa
NADH-ubiquinone oxidoreductase MNLL subunit
complex I MNLL subunit
complex I-MNLL

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004545.4NP_004536.3  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1

    Status: VALIDATED

    Source sequence(s)
    BM052981, BX476462
    Consensus CDS
    CCDS9901.1
    UniProtKB/Swiss-Prot
    A0AV68
    Related
    ENSP00000475170.1, ENST00000605997.6
    Conserved Domains (1) summary
    pfam08040
    Location:158
    NADH_oxidored; MNLL subunit

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    92116123..92121706 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047431421.1XP_047287377.1  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 isoform X1

    UniProtKB/Swiss-Prot
    A0AV68
    Related
    ENSP00000450776.1, ENST00000555441.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    86345661..86351545 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)