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NDUFA7 NADH:ubiquinone oxidoreductase subunit A7 [ Homo sapiens (human) ]

Gene ID: 4701, updated on 5-Aug-2018

Summary

Official Symbol
NDUFA7provided by HGNC
Official Full Name
NADH:ubiquinone oxidoreductase subunit A7provided by HGNC
Primary source
HGNC:HGNC:7691
See related
Ensembl:ENSG00000267855 MIM:602139; Vega:OTTHUMG00000182459
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B14.5a; CI-B14.5a
Summary
This gene encodes a subunit of NADH:ubiquinone oxidoreductase (complex I), which is a multiprotein complex located in the inner mitochondrial membrane. Complex I functions in the transfer of electrons from NADH to the respiratory chain. [provided by RefSeq, Mar 2011]
Expression
Ubiquitous expression in heart (RPKM 24.4), kidney (RPKM 16.8) and 25 other tissues See more
Orthologs

Genomic context

See NDUFA7 in Genome Data Viewer
Location:
19p13.2
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (8308603..8321413, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (8373492..8386452, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ceramide synthase 4 Neighboring gene uncharacterized LOC107985282 Neighboring gene CD320 molecule Neighboring gene ribosomal protein S28 Neighboring gene KN motif and ankyrin repeat domains 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NADH dehydrogenase (ubiquinone) activity NAS
Non-traceable Author Statement
more info
PubMed 
structural constituent of ribosome ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
mitochondrial electron transport, NADH to ubiquinone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial electron transport, NADH to ubiquinone NAS
Non-traceable Author Statement
more info
PubMed 
mitochondrial respiratory chain complex I assembly TAS
Traceable Author Statement
more info
 
mitochondrial translation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial respiratory chain complex I IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial respiratory chain complex I IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial respiratory chain complex I NAS
Non-traceable Author Statement
more info
PubMed 
mitochondrial ribosome ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7
Names
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa
NADH-ubiquinone oxidoreductase subunit B14.5a
complex I B14.5a subunit

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028213.2 RefSeqGene

    Range
    4984..15047
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005001.4NP_004992.2  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7

    See identical proteins and their annotated locations for NP_004992.2

    Status: REVIEWED

    Source sequence(s)
    AC010323, BC003102
    Consensus CDS
    CCDS42492.1
    UniProtKB/Swiss-Prot
    O95182
    Related
    ENSP00000301457.1, OTTHUMP00000269363, ENST00000301457.2, OTTHUMT00000461373
    Conserved Domains (1) summary
    pfam07347
    Location:5102
    CI-B14_5a; NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a)

RNA

  1. NR_135539.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010323, BC003102, CD172691, CR975510

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    8308603..8321413 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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