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MTHFR methylenetetrahydrofolate reductase [ Pan troglodytes (chimpanzee) ]

Gene ID: 469800, updated on 24-Mar-2019

Summary

Official Symbol
MTHFRprovided by VGNC
Official Full Name
methylenetetrahydrofolate reductaseprovided by VGNC
Primary source
VGNC:VGNC:14309
See related
Ensembl:ENSPTRG00000000153
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs

Genomic context

See MTHFR in Genome Data Viewer
Location:
chromosome: 1
Exon count:
13
Annotation release Status Assembly Chr Location
105 current Clint_PTRv2 (GCF_002880755.1) 1 NC_036879.1 (10494942..10514996, complement)
104 previous assembly Pan_tro 3.0 (GCF_000001515.7) 1 NC_006468.4 (11261754..11281062, complement)
103 previous assembly Pan_troglodytes-2.1.4 (GCF_000001515.6) 1 NC_006468.3 (11938999..11955041, complement)

Chromosome 1 - NC_036879.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107974908 Neighboring gene splicing factor 3B subunit 4-like Neighboring gene chromosome 1 C1orf167 homolog Neighboring gene chloride voltage-gated channel 6 Neighboring gene natriuretic peptide A Neighboring gene natriuretic peptide B

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Antifolate resistance, organism-specific biosystem (from KEGG)
    Antifolate resistance, organism-specific biosystemSince the 1940s, antifolates have played a pivotal role in drug treatment of malignant, microbial, parasitic and chronic inflammatory diseases. The molecular basis of the anti-proliferative activity ...
  • Antifolate resistance, conserved biosystem (from KEGG)
    Antifolate resistance, conserved biosystemSince the 1940s, antifolates have played a pivotal role in drug treatment of malignant, microbial, parasitic and chronic inflammatory diseases. The molecular basis of the anti-proliferative activity ...
  • Carbon metabolism, organism-specific biosystem (from KEGG)
    Carbon metabolism, organism-specific biosystemCarbon metabolism is the most basic aspect of life. This map presents an overall view of central carbon metabolism, where the number of carbons is shown for each compound denoted by a circle, excludi...
  • Carbon metabolism, conserved biosystem (from KEGG)
    Carbon metabolism, conserved biosystemCarbon metabolism is the most basic aspect of life. This map presents an overall view of central carbon metabolism, where the number of carbons is shown for each compound denoted by a circle, excludi...
  • Metabolic pathways, organism-specific biosystem (from KEGG)
    Metabolic pathways, organism-specific biosystem
    Metabolic pathways
  • One Carbon Metabolism, organism-specific biosystem (from WikiPathways)
    One Carbon Metabolism, organism-specific biosystemThis one-carbon metabolism pathway is centered around folate. Folate has two key carbon-carbon double bonds. Saturating one of them yields dihydrofolate (DHF) and adding an additional molecule of hyd...
  • One carbon pool by folate, organism-specific biosystem (from KEGG)
    One carbon pool by folate, organism-specific biosystem
    One carbon pool by folate
  • One carbon pool by folate, conserved biosystem (from KEGG)
    One carbon pool by folate, conserved biosystem
    One carbon pool by folate

General gene information

Markers

Homology

General protein information

Preferred Names
methylenetetrahydrofolate reductase
Names
5,10-methylenetetrahydrofolate reductase (NADPH)
methylenetetrahydrofolate reductase (NAD(P)H)
XP_001141040.3
XP_009446611.3
XP_009446616.3
XP_009446630.3
XP_009446635.3

NCBI Reference Sequences (RefSeq)

RefSeqs of Annotated Genomes: Pan troglodytes Annotation Release 105 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Clint_PTRv2 Primary Assembly

Genomic

  1. NC_036879.1 Reference Clint_PTRv2 Primary Assembly

    Range
    10494942..10514996 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001141040.5XP_001141040.3  methylenetetrahydrofolate reductase isoform X3

    Conserved Domains (1) summary
    cl00246
    Location:60626
    MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...
  2. XM_009448336.3XP_009446611.3  methylenetetrahydrofolate reductase isoform X1

    Conserved Domains (1) summary
    cl00246
    Location:101667
    MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...
  3. XM_009448355.3XP_009446630.3  methylenetetrahydrofolate reductase isoform X3

    Conserved Domains (1) summary
    cl00246
    Location:60626
    MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...
  4. XM_009448360.3XP_009446635.3  methylenetetrahydrofolate reductase isoform X4

    Conserved Domains (1) summary
    cl00246
    Location:1544
    MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...
  5. XM_009448341.3XP_009446616.3  methylenetetrahydrofolate reductase isoform X2

    Conserved Domains (1) summary
    cl00246
    Location:100666
    MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...
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