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NDN necdin, MAGE family member [ Homo sapiens (human) ]

Gene ID: 4692, updated on 6-May-2021

Summary

Official Symbol
NDNprovided by HGNC
Official Full Name
necdin, MAGE family memberprovided by HGNC
Primary source
HGNC:HGNC:7675
See related
Ensembl:ENSG00000182636 MIM:602117
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PWCR; HsT16328
Summary
This intronless gene is located in the Prader-Willi syndrome deletion region. It is an imprinted gene and is expressed exclusively from the paternal allele. Studies in mouse suggest that the protein encoded by this gene may suppress growth in postmitotic neurons. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

See NDN in Genome Data Viewer
Location:
15q11.2
Exon count:
1
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (23685400..23687305, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (23930547..23932452, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene makorin ring finger protein 3 Neighboring gene MAGE family member L2 Neighboring gene RNA, U6 small nuclear 741, pseudogene Neighboring gene uncharacterized LOC107984787

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Prader-Willi syndrome
MedGen: C0032897 OMIM: 176270 GeneReviews: Prader-Willi Syndrome
Compare labs

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated 2012-04-26)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated 2012-04-26)

ClinGen Genome Curation Page

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables gamma-tubulin binding IEA
Inferred from Electronic Annotation
more info
 
enables promoter-specific chromatin binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in axon extension IEA
Inferred from Electronic Annotation
more info
 
involved_in axonal fasciculation IEA
Inferred from Electronic Annotation
more info
 
involved_in central nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
involved_in genetic imprinting IEA
Inferred from Electronic Annotation
more info
 
involved_in glial cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in multicellular organismal homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron migration IEA
Inferred from Electronic Annotation
more info
 
involved_in neurotrophin TRK receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein deacetylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in post-embryonic development IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of growth IEA
Inferred from Electronic Annotation
more info
 
involved_in respiratory system process IEA
Inferred from Electronic Annotation
more info
 
involved_in sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in centrosome IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
necdin
Names
Prader-Willi syndrome chromosome region
necdin homolog
necdin, melanoma antigen (MAGE) family member
necdin-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_009380.1 RefSeqGene

    Range
    4999..6904
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1047

mRNA and Protein(s)

  1. NM_002487.3NP_002478.1  necdin

    See identical proteins and their annotated locations for NP_002478.1

    Status: REVIEWED

    Source sequence(s)
    AC124309
    Consensus CDS
    CCDS10014.1
    UniProtKB/Swiss-Prot
    Q99608
    UniProtKB/TrEMBL
    X5D982
    Related
    ENSP00000497916.1, ENST00000649030.2
    Conserved Domains (1) summary
    pfam01454
    Location:105273
    MAGE; MAGE family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    23685400..23687305 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_021160017.1 Reference GRCh38.p13 PATCHES

    Range
    4633210..4635115 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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