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NCK1 NCK adaptor protein 1 [ Homo sapiens (human) ]

Gene ID: 4690, updated on 5-Sep-2021

Summary

Official Symbol
NCK1provided by HGNC
Official Full Name
NCK adaptor protein 1provided by HGNC
Primary source
HGNC:HGNC:7664
See related
Ensembl:ENSG00000158092 MIM:600508
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NCK; nck-1; NCKalpha
Summary
The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jun 2010]
Expression
Ubiquitous expression in lymph node (RPKM 10.1), fat (RPKM 9.3) and 25 other tissues See more
Orthologs
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Genomic context

See NCK1 in Genome Data Viewer
Location:
3q22.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (136862208..136951606)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (136581050..136670448)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene stromal antigen 1 Neighboring gene DnaJ heat shock protein family (Hsp40) member C8 pseudogene Neighboring gene solute carrier family 35 member G2 Neighboring gene NCK1 divergent transcript Neighboring gene RAD51AP1 pseudogene 1 Neighboring gene IL20RB antisense RNA 1 Neighboring gene CRISPRi-validated cis-regulatory element chr3.4045 Neighboring gene interleukin 20 receptor subunit beta

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Biological insights from 108 schizophrenia-associated genetic loci.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef The association of HIV-1 Nef with Vav1, Pak2, and Nck1 is greatly reduced in SLP76-deficient T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC12668

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cadherin binding HDA PubMed 
enables cytoskeletal anchor activity NAS
Non-traceable Author Statement
more info
PubMed 
enables ephrin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables eukaryotic initiation factor eIF2 binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein-macromolecule adaptor activity IC
Inferred by Curator
more info
PubMed 
enables protein-macromolecule adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables receptor tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables receptor tyrosine kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables signaling adaptor activity NAS
Non-traceable Author Statement
more info
PubMed 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor complex adaptor activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in T cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in actin filament organization IEA
Inferred from Electronic Annotation
more info
 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ephrin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in lamellipodium assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of PERK-mediated unfolded protein response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of PERK-mediated unfolded protein response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell death IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-serine dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of actin filament polymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cap-dependent translational initiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cap-independent translational initiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of neuron projection development IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of translation in response to endoplasmic reticulum stress IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of translation in response to endoplasmic reticulum stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in response to other organism IEA
Inferred from Electronic Annotation
more info
 
involved_in signal complex assembly NAS
Non-traceable Author Statement
more info
PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in substrate-dependent cell migration, cell extension IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell-cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of protein phosphatase type 1 complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in ribosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in vesicle membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cytoplasmic protein NCK1
Names
NCK tyrosine kinase
SH2/SH3 adaptor protein NCK-alpha
melanoma NCK protein
non-catalytic region of tyrosine kinase

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190796.3NP_001177725.1  cytoplasmic protein NCK1 isoform 2

    See identical proteins and their annotated locations for NP_001177725.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate 5' sequence compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC011597, AK301460, BC006403, BP339594
    Consensus CDS
    CCDS54644.1
    UniProtKB/Swiss-Prot
    P16333
    Related
    ENSP00000419631.1, ENST00000469404.1
    Conserved Domains (3) summary
    cd10408
    Location:216312
    SH2_Nck1; Src homology 2 (SH2) domain found in Nck
    cd11901
    Location:4498
    SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
    cd11904
    Location:129185
    SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein
  2. NM_001291999.2NP_001278928.1  cytoplasmic protein NCK1 isoform 1

    See identical proteins and their annotated locations for NP_001278928.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 encode the same protein (isoform 1).
    Source sequence(s)
    AC011597, BC006403, DA855124
    Consensus CDS
    CCDS3092.1
    UniProtKB/Swiss-Prot
    P16333
    UniProtKB/TrEMBL
    A0A0S2Z4Y3
    Related
    ENSP00000417273.1, ENST00000481752.6
    Conserved Domains (4) summary
    cd10408
    Location:280376
    SH2_Nck1; Src homology 2 (SH2) domain found in Nck
    cd11900
    Location:361
    SH3_Nck1_1; First Src Homology 3 domain of Nck1 adaptor protein
    cd11901
    Location:108162
    SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
    cd11904
    Location:193249
    SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein
  3. NM_006153.6NP_006144.1  cytoplasmic protein NCK1 isoform 1

    See identical proteins and their annotated locations for NP_006144.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer protein (isoform 1). Variants 1 and 3 encode the same protein.
    Source sequence(s)
    AC011597, BC006403, DB117533
    Consensus CDS
    CCDS3092.1
    UniProtKB/Swiss-Prot
    P16333
    UniProtKB/TrEMBL
    A0A0S2Z4Y3
    Related
    ENSP00000288986.2, ENST00000288986.6
    Conserved Domains (4) summary
    cd10408
    Location:280376
    SH2_Nck1; Src homology 2 (SH2) domain found in Nck
    cd11900
    Location:361
    SH3_Nck1_1; First Src Homology 3 domain of Nck1 adaptor protein
    cd11901
    Location:108162
    SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
    cd11904
    Location:193249
    SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    136862208..136951606
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453538.1XP_024309306.1  cytoplasmic protein NCK1 isoform X1

    Conserved Domains (4) summary
    cd10408
    Location:280376
    SH2_Nck1; Src homology 2 (SH2) domain found in Nck
    cd11900
    Location:361
    SH3_Nck1_1; First Src Homology 3 domain of Nck1 adaptor protein
    cd11901
    Location:108162
    SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
    cd11904
    Location:193249
    SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein
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