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NCK1 NCK adaptor protein 1 [ Homo sapiens (human) ]

Gene ID: 4690, updated on 26-Nov-2016
Official Symbol
NCK1provided by HGNC
Official Full Name
NCK adaptor protein 1provided by HGNC
Primary source
HGNC:HGNC:7664
See related
Ensembl:ENSG00000158092 HPRD:02740; MIM:600508; Vega:OTTHUMG00000159781
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NCK; nck-1; NCKalpha
Summary
The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jun 2010]
Orthologs
Location:
3q22.3
Exon count:
5
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 3 NC_000003.12 (136862208..136951610)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (136581050..136670446)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene stromal antigen 1 Neighboring gene DnaJ heat shock protein family (Hsp40) member C8 pseudogene Neighboring gene solute carrier family 35 member G2 Neighboring gene NCK1 antisense RNA 1 (head to head) Neighboring gene RAD51 associated protein 1 pseudogene 1 Neighboring gene uncharacterized LOC107986136 Neighboring gene interleukin 20 receptor subunit beta Neighboring gene RNA, 5S ribosomal pseudogene 142

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Nef nef The association of HIV-1 Nef with Vav1, Pak2, and Nck1 is greatly reduced in SLP76-deficient T cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC12668

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ARF guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
SH3/SH2 adaptor activity NAS
Non-traceable Author Statement
more info
PubMed 
cadherin binding involved in cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeletal adaptor activity NAS
Non-traceable Author Statement
more info
PubMed 
ephrin receptor binding IEA
Inferred from Electronic Annotation
more info
 
eukaryotic initiation factor eIF2 binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding, bridging IC
Inferred by Curator
more info
PubMed 
protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor signaling complex scaffold activity NAS
Non-traceable Author Statement
more info
PubMed 
receptor tyrosine kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Fc-gamma receptor signaling pathway involved in phagocytosis TAS
Traceable Author Statement
more info
 
T cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
T cell receptor signaling pathway TAS
Traceable Author Statement
more info
 
actin filament organization IEA
Inferred from Electronic Annotation
more info
 
ephrin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
lamellipodium assembly IEA
Inferred from Electronic Annotation
more info
 
negative regulation of PERK-mediated unfolded protein response IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell death IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-serine dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of actin filament polymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cap-dependent translational initiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cap-independent translational initiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of neuron projection development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of translation in response to endoplasmic reticulum stress IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
response to other organism IEA
Inferred from Electronic Annotation
more info
 
signal complex assembly NAS
Non-traceable Author Statement
more info
PubMed 
substrate-dependent cell migration, cell extension IEA
Inferred from Electronic Annotation
more info
 
vascular endothelial growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
cell-cell adherens junction IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
protein phosphatase type 1 complex IDA
Inferred from Direct Assay
more info
PubMed 
ribosome IDA
Inferred from Direct Assay
more info
PubMed 
trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
 
vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
cytoplasmic protein NCK1
Names
NCK tyrosine kinase
SH2/SH3 adaptor protein NCK-alpha
melanoma NCK protein
non-catalytic region of tyrosine kinase

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190796.2NP_001177725.1  cytoplasmic protein NCK1 isoform 2

    See identical proteins and their annotated locations for NP_001177725.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate 5' sequence compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC011597, AK301460, BC006403, BP339594
    Consensus CDS
    CCDS54644.1
    UniProtKB/Swiss-Prot
    P16333
    Related
    ENSP00000419631, OTTHUMP00000216479, ENST00000469404, OTTHUMT00000357287
    Conserved Domains (3) summary
    cd10408
    Location:216312
    SH2_Nck1; Src homology 2 (SH2) domain found in Nck
    cd11901
    Location:4498
    SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
    cd11904
    Location:129185
    SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein
  2. NM_001291999.1NP_001278928.1  cytoplasmic protein NCK1 isoform 1

    See identical proteins and their annotated locations for NP_001278928.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 encode the same protein (isoform 1).
    Source sequence(s)
    AC011597, BC006403, DA855124
    Consensus CDS
    CCDS3092.1
    UniProtKB/Swiss-Prot
    P16333
    UniProtKB/TrEMBL
    A0A0S2Z4Y3
    Related
    ENSP00000417273, OTTHUMP00000216492, ENST00000481752, OTTHUMT00000357307
    Conserved Domains (4) summary
    cd10408
    Location:280376
    SH2_Nck1; Src homology 2 (SH2) domain found in Nck
    cd11900
    Location:361
    SH3_Nck1_1; First Src Homology 3 domain of Nck1 adaptor protein
    cd11901
    Location:108162
    SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
    cd11904
    Location:193249
    SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein
  3. NM_006153.5NP_006144.1  cytoplasmic protein NCK1 isoform 1

    See identical proteins and their annotated locations for NP_006144.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer protein (isoform 1). Variants 1 and 3 encode the same protein.
    Source sequence(s)
    AC011597, BC006403, DB117533
    Consensus CDS
    CCDS3092.1
    UniProtKB/Swiss-Prot
    P16333
    UniProtKB/TrEMBL
    A0A0S2Z4Y3
    Related
    ENSP00000288986, OTTHUMP00000216478, ENST00000288986, OTTHUMT00000357286
    Conserved Domains (4) summary
    cd10408
    Location:280376
    SH2_Nck1; Src homology 2 (SH2) domain found in Nck
    cd11900
    Location:361
    SH3_Nck1_1; First Src Homology 3 domain of Nck1 adaptor protein
    cd11901
    Location:108162
    SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
    cd11904
    Location:193249
    SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p7 Primary Assembly

    Range
    136862208..136951610
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 Alternate CHM1_1.1

    Range
    136544712..136634091
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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