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NCBP1 nuclear cap binding protein subunit 1 [ Homo sapiens (human) ]

Gene ID: 4686, updated on 10-Oct-2019

Summary

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Official Symbol
NCBP1provided by HGNC
Official Full Name
nuclear cap binding protein subunit 1provided by HGNC
Primary source
HGNC:HGNC:7658
See related
Ensembl:ENSG00000136937 MIM:600469
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NCBP; Sto1; CBP80
Summary
The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein promotes high-affinity mRNA-cap binding and associates with the CTD of RNA polymerase II. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 9.3), lymph node (RPKM 7.9) and 25 other tissues See more
Orthologs
mouse all

Genomic context

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See NCBP1 in Genome Data Viewer
Location:
9q22.33
Exon count:
23
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (97633423..97673748)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (100395705..100436030)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376168 Neighboring gene tropomodulin 1 Neighboring gene Sharpr-MPRA regulatory region 9871 Neighboring gene thiosulfate sulfurtransferase like domain containing 2 Neighboring gene uncharacterized LOC105376171 Neighboring gene XPA, DNA damage recognition and repair factor Neighboring gene keratin 18 pseudogene 13 Neighboring gene papillary thyroid carcinoma susceptibility candidate 2 Neighboring gene VISTA enhancer hs1595

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. CBP80-promoted mRNP rearrangements during the pioneer round of translation, nonsense-mediated mRNA decay, and thereafter. Maquat LE, et al. Cold Spring Harb Symp Quant Biol, 2010. PMID 21447822, Free PMC Article
  2. Cellular cap-binding proteins associate with influenza virus mRNAs. Bier K, et al. J Gen Virol, 2011 Jul. PMID 21402597
  3. Diverse role of three tyrosines in binding of the RNA 5' cap to the human nuclear cap binding complex. Worch R, et al. J Mol Biol, 2009 Jan 16. PMID 19026660
  4. Cotranscriptional mRNP assembly: from the DNA to the nuclear pore. Aguilera A. Curr Opin Cell Biol, 2005 Jun. PMID 15901492
  5. Cloning of a complementary DNA encoding an 80 kilodalton nuclear cap binding protein. Kataoka N, et al. Nucleic Acids Res, 1994 Sep 25. PMID 7937105, Free PMC Article

See all (129) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results suggest that rev protein, HIV-1 (Rev) regulates the association of nuclear cap-binding protein NCBP 80 kDa subunit (CBP80) and eukaryotic translation initiation factor 4A1 (eIF4AI) with the unspliced mRNA in the cytoplasm and the nucleus, respectively, during HIV-1 replication.
    Title: A Rev-CBP80-eIF4AI complex drives Gag synthesis from the HIV-1 unspliced mRNA.
  2. Study proposes the existence of an alternative cap-binding complex involving NCBP1 and NCBP3 that plays a key role in mRNA biogenesis.
    Title: mRNA export through an additional cap-binding complex consisting of NCBP1 and NCBP3.
  3. down-regulation of CTIF using a small interfering RNA causes a redistribution of CBP80 from polysome fractions to subpolysome fractions, without significant consequence to eIF4E distribution
    Title: Translation initiation on mRNAs bound by nuclear cap-binding protein complex CBP80/20 requires interaction between CBP80/20-dependent translation initiation factor and eukaryotic translation initiation factor 3g.
  4. Cellular processes by which CBP80-CBP20 -bound messenger ribonucleoproteins (mRNPs) are remodeled to eIF4E-bound mRNPs, are overviewed.
    Title: CBP80-promoted mRNP rearrangements during the pioneer round of translation, nonsense-mediated mRNA decay, and thereafter.
  5. Viral mRNA associates with the influenza virus A NS1 and the cellular NCBP1 of the nuclear cap-binding complex.
    Title: Cellular cap-binding proteins associate with influenza virus mRNAs.
  6. UPF1 binds PTC-containing mRNA more efficiently than the corresponding PTC-free mRNA in a way that is promoted by the UPF1-CBP80 interaction.
    Title: UPF1 association with the cap-binding protein, CBP80, promotes nonsense-mediated mRNA decay at two distinct steps.
  7. resolution X-ray structure for a cap-binding complex (CBC)-importin-alpha complex that provides a detailed picture for how importin-alpha binds to the CBP80 subunit of the CBC.
    Title: The molecular basis for the regulation of the cap-binding complex by the importins.
  8. a new MIF4G domain-containing protein, CTIF (CBP80/20-dependent translation initiation factor) that interacts directly with CBP80 and is part of the CBP80/20-dependent translation initiation complex
    Title: A new MIF4G domain-containing protein, CTIF, directs nuclear cap-binding protein CBP80/20-dependent translation.
  9. The authors could distinguish two tyrosines, Y43 and Y20, in stabilization of the cap inside the cap-binding complex binding pocket.
    Title: Diverse role of three tyrosines in binding of the RNA 5' cap to the human nuclear cap binding complex.
  10. We show that NELF interacts with the nuclear cap binding complex (CBC), a heterodimeric, multifunctional factor that plays important roles in several mRNA processing steps, and the two factors together participate in the 3' end processing of histone mRNAs
    Title: NELF interacts with CBC and participates in 3' end processing of replication-dependent histone mRNAs.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

Description
The FOXE1 locus is a major genetic determinant for radiation-related thyroid carcinoma in Chernobyl.
NHGRI GWA Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from BioSystems

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  • Abortive elongation of HIV-1 transcript in the absence of Tat, organism-specific biosystem (from REACTOME)
    Abortive elongation of HIV-1 transcript in the absence of Tat, organism-specific biosystemThis event was inferred from the corresponding Reactome human Poll II transcription elongation event. The details specific to HIV-1 transcription elongation are described below. In the absence of th...
  • Cap binding complex, organism-specific biosystem (from KEGG)
    Cap binding complex, organism-specific biosystemStructural complex; Genetic information processing; Spliceosome
  • Cap binding complex, conserved biosystem (from KEGG)
    Cap binding complex, conserved biosystemStructural complex; Genetic information processing; Spliceosome
  • Cleavage of Growing Transcript in the Termination Region, organism-specific biosystem (from REACTOME)
    Cleavage of Growing Transcript in the Termination Region, organism-specific biosystemThis section includes the cleavage of both polyadenylated and non-polyadenylated transcripts. In the former case polyadenylation has to precede transcript cleavage, while in the latter case there is ...
  • Disease, organism-specific biosystem (from REACTOME)
    Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
  • Diseases of signal transduction, organism-specific biosystem (from REACTOME)
    Diseases of signal transduction, organism-specific biosystemSignaling processes are central to human physiology (e.g., Pires-da Silva & Sommer 2003), and their disruption by either germ-line and somatic mutation can lead to serious disease. Here, the molecula...
  • FGFR2 alternative splicing, organism-specific biosystem (from REACTOME)
    FGFR2 alternative splicing, organism-specific biosystemAlternative splicing of the FGFR2 nascent mRNA generates an epithelial specific isoform (FGFR2 IIIb) and a mesenchymal specific isoform (FGFR2 IIIc). The inclusion of exon 8 in FGFR2 IIIb or exon 9 ...
  • FGFR2 mutant receptor activation, organism-specific biosystem (from REACTOME)
    FGFR2 mutant receptor activation, organism-specific biosystemAutosomal dominant mutations in FGFR2 are associated with the development of a range of skeletal disorders including Beare-Stevensen cutis gyrata syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome, ...
  • Formation of HIV elongation complex in the absence of HIV Tat, organism-specific biosystem (from REACTOME)
    Formation of HIV elongation complex in the absence of HIV Tat, organism-specific biosystem
    Formation of HIV elongation complex in the absence of HIV Tat
  • Formation of HIV-1 elongation complex containing HIV-1 Tat, organism-specific biosystem (from REACTOME)
    Formation of HIV-1 elongation complex containing HIV-1 Tat, organism-specific biosystemThis HIV-1 event was inferred from the corresponding human RNA Poll II transcription event in Reactome. The details relevant to HIV-1 are described below. For a more detailed description of the gener...
  • Formation of RNA Pol II elongation complex, organism-specific biosystem (from REACTOME)
    Formation of RNA Pol II elongation complex, organism-specific biosystemTFIIS is a transcription factor involved in different phases of transcription, occurring in a major ubiquitous form and other tissue specific forms. TFIIS stimulates RNA Pol II complex out of elonga...
  • Formation of the Early Elongation Complex, organism-specific biosystem (from REACTOME)
    Formation of the Early Elongation Complex, organism-specific biosystemTranscription elongation by RNA polymerase II (RNAPII) is controlled by a number of trans-acting transcription elongation factors as well as by cis-acting elements. Transcription elongation is a rat...
  • Formation of the HIV-1 Early Elongation Complex, organism-specific biosystem (from REACTOME)
    Formation of the HIV-1 Early Elongation Complex, organism-specific biosystemThis HIV-1 event was inferred from the corresponding human RNA Poll II transcription event. The details relevant to HIV-1 are described below. Formation of the early elongation complex involves hypo...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • HIV Infection, organism-specific biosystem (from REACTOME)
    HIV Infection, organism-specific biosystemThe global pandemic of Human Immunodeficiency Virus (HIV) infection has resulted in tens of millions of people infected by the virus and millions more affected. UNAIDS estimates around 40 million ...
  • HIV Life Cycle, organism-specific biosystem (from REACTOME)
    HIV Life Cycle, organism-specific biosystemThe life cycle of HIV-1 is divided into early and late phases, shown schematically in the figure. In the early phase, an HIV-1 virion binds to receptors and co-receptors on the human host cell surfac...
  • HIV Transcription Elongation, organism-specific biosystem (from REACTOME)
    HIV Transcription Elongation, organism-specific biosystemIn the absence of the HIV-1 protein Tat, transcription of the proviral DNA is inefficient and results in the production of truncated transcripts (Kao et al., 1987). While initiation of transcription ...
  • Infectious disease, organism-specific biosystem (from REACTOME)
    Infectious disease, organism-specific biosystem
    Infectious disease
  • Late Phase of HIV Life Cycle, organism-specific biosystem (from REACTOME)
    Late Phase of HIV Life Cycle, organism-specific biosystemThe late phase of the HIV-1 life cycle includes the regulated expression of the HIV gene products and the assembly of viral particles. The assembly of viral particles will be covered in a later relea...
  • Metabolism of non-coding RNA, organism-specific biosystem (from REACTOME)
    Metabolism of non-coding RNA, organism-specific biosystemThe term non-coding is commonly employed for RNA that does not encode a protein, but this does not mean that such RNAs do not contain information nor have function. There is considerable evidence tha...
  • Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), organism-specific biosystem (from REACTOME)
    Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), organism-specific biosystemDuring normal translation termination eRF3 associates with the ribosome and then interacts with PABP bound to the polyadenylate tail of the mRNA to release the ribosome and allow a new round of trans...
  • Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), organism-specific biosystem (from REACTOME)
    Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), organism-specific biosystemNonsense-mediated decay has been observed with mRNAs that do not have an exon junction complex (EJC) downstream of the termination codon (reviewed in Isken and Maquat 2007, Chang et al. 2007, Behm-An...
  • Nonsense-Mediated Decay (NMD), organism-specific biosystem (from REACTOME)
    Nonsense-Mediated Decay (NMD), organism-specific biosystemThe Nonsense-Mediated Decay (NMD) pathway activates the destruction of mRNAs containing premature termination codons (PTCs) (reviewed in Isken and Maquat 2007, Chang et al. 2007, Behm-Ansmant et al. ...
  • Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem (from REACTOME)
    Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystemCo-transcriptional pre-mRNA splicing is not obligatory. Pre-mRNA splicing begins co-transcriptionally and often continues post-transcriptionally. Human genes contain an average of nine introns per ge...
  • Processing of Capped Intronless Pre-mRNA, organism-specific biosystem (from REACTOME)
    Processing of Capped Intronless Pre-mRNA, organism-specific biosystemCo-transcriptional pre-mRNA splicing is not obligatory. Pre-mRNA splicing begins co-transcriptionally and often continues post-transcriptionally. Human genes contain an average of nine introns per ge...
  • Processing of Intronless Pre-mRNAs, organism-specific biosystem (from REACTOME)
    Processing of Intronless Pre-mRNAs, organism-specific biosystemThe 3' ends of eukaryotic mRNAs are generated by posttranscriptional processing of an extended primary transcript. For almost all RNAs, 3' processing consists of two steps: The mRNA is first cleaved ...
  • RNA Polymerase II Pre-transcription Events, organism-specific biosystem (from REACTOME)
    RNA Polymerase II Pre-transcription Events, organism-specific biosystem
    RNA Polymerase II Pre-transcription Events
  • RNA Polymerase II Transcription, organism-specific biosystem (from REACTOME)
    RNA Polymerase II Transcription, organism-specific biosystem
    RNA Polymerase II Transcription
  • RNA Polymerase II Transcription Elongation, organism-specific biosystem (from REACTOME)
    RNA Polymerase II Transcription Elongation, organism-specific biosystemThe mechanisms governing the process of elongation during eukaryotic mRNA synthesis are being unraveled by recent studies. These studies have led to the expected discovery of a diverse collection of ...
  • RNA Polymerase II Transcription Termination, organism-specific biosystem (from REACTOME)
    RNA Polymerase II Transcription Termination, organism-specific biosystemThe detailed annotation of this section will be completed in the next release.
  • RNA polymerase II transcribes snRNA genes, organism-specific biosystem (from REACTOME)
    RNA polymerase II transcribes snRNA genes, organism-specific biosystemSmall nuclear RNAs (snRNAs) play key roles in splicing and some of them, specifically the U1 and U2 snRNAs, are encoded by multicopy snRNA gene clusters containing tandem arrays of genes, about 30 in...
  • RNA transport, organism-specific biosystem (from KEGG)
    RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
  • RNA transport, conserved biosystem (from KEGG)
    RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
  • SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs, organism-specific biosystem (from REACTOME)
    SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs, organism-specific biosystemThere are two well-documented trans-acting factors required for histone pre-mRNA processing. These are:1 Stem-loop binding protein (SLBP), also termed hairpin binding protein (HBP). This 32 kDa pro...
  • SLBP independent Processing of Histone Pre-mRNAs, organism-specific biosystem (from REACTOME)
    SLBP independent Processing of Histone Pre-mRNAs, organism-specific biosystemThis class of mRNAs is expressed from genes that lack introns yet the transcripts end in polyA tails. These tails are formed by a mechanism similar to that for pre-mRNAs containing introns. It is ...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by FGFR, organism-specific biosystem (from REACTOME)
    Signaling by FGFR, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
  • Signaling by FGFR in disease, organism-specific biosystem (from REACTOME)
    Signaling by FGFR in disease, organism-specific biosystemA number of skeletal and developmental diseases have been shown to arise as a result of mutations in the FGFR1, 2 and 3 genes. These include dwarfism syndromes (achondroplasia, hypochondroplasia and...
  • Signaling by FGFR2, organism-specific biosystem (from REACTOME)
    Signaling by FGFR2, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
  • Signaling by FGFR2 IIIa TM, organism-specific biosystem (from REACTOME)
    Signaling by FGFR2 IIIa TM, organism-specific biosystemA soluble truncated form of FGFR2 is aberrantly expressed in an Apert Syndrome mouse model and inhibits FGFR signaling in vitro and in vivo. This variant, termed FGFR IIIa TM, arises from an misspli...
  • Signaling by FGFR2 in disease, organism-specific biosystem (from REACTOME)
    Signaling by FGFR2 in disease, organism-specific biosystemThe FGFR2 gene has been shown to be subject to activating mutations and gene amplification leading to a variety of proliferative and developmental disorders depending on whether these events occur in...
  • Spliceosome, organism-specific biosystem (from KEGG)
    Spliceosome, organism-specific biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
  • Spliceosome, conserved biosystem (from KEGG)
    Spliceosome, conserved biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
  • Tat-mediated elongation of the HIV-1 transcript, organism-specific biosystem (from REACTOME)
    Tat-mediated elongation of the HIV-1 transcript, organism-specific biosystemThe Tat protein is a viral transactivator protein that regulates HIV-1 gene expression by controlling RNA Pol II-mediated elongation (reviewed in Karn 1999; Taube et al. 1999; Liou et al. 2004; Barb...
  • Transcription of the HIV genome, organism-specific biosystem (from REACTOME)
    Transcription of the HIV genome, organism-specific biosystemExpression of the integrated HIV-1 provirus is dependent on the host cell Pol II transcription machinery, but is regulated in critical ways by HIV-1 Tat and Rev proteins. The long terminal repeats (L...
  • Transport of Mature Transcript to Cytoplasm, organism-specific biosystem (from REACTOME)
    Transport of Mature Transcript to Cytoplasm, organism-specific biosystemTransport of mRNA through the Nuclear Pore Complex (NPC) is a dynamic process involving distinct machinery and receptor subsets. The separation of the two compartments and the regulation of this tran...
  • Transport of Mature mRNA Derived from an Intronless Transcript, organism-specific biosystem (from REACTOME)
    Transport of Mature mRNA Derived from an Intronless Transcript, organism-specific biosystemTransport of mRNA from the nucleus to the cytoplasm, where it is translated into protein, is highly selective and closely coupled to correct RNA processing.
  • Transport of Mature mRNA derived from an Intron-Containing Transcript, organism-specific biosystem (from REACTOME)
    Transport of Mature mRNA derived from an Intron-Containing Transcript, organism-specific biosystemTransport of mRNA from the nucleus to the cytoplasm, where it is translated into protein, is highly selective and closely coupled to correct RNA processing. This coupling is achieved by the nuclear p...
  • Transport of Mature mRNAs Derived from Intronless Transcripts, organism-specific biosystem (from REACTOME)
    Transport of Mature mRNAs Derived from Intronless Transcripts, organism-specific biosystemTransport of mature mRNAs derived from intronless transcripts require some of the same protein complexes as mRNAs derived from intron containing complexes, including TAP and Aly/Ref. However a number...
  • Transport of the SLBP Dependant Mature mRNA, organism-specific biosystem (from REACTOME)
    Transport of the SLBP Dependant Mature mRNA, organism-specific biosystemTransport of U7 snRNP and stem-loop binding protein (SLBP) processed mRNA.
  • Transport of the SLBP independent Mature mRNA, organism-specific biosystem (from REACTOME)
    Transport of the SLBP independent Mature mRNA, organism-specific biosystemTransport of the SLBP independent Mature mRNA through the nuclear pore.
  • mRNA 3'-end processing, organism-specific biosystem (from REACTOME)
    mRNA 3'-end processing, organism-specific biosystemThe 3' ends of eukaryotic mRNAs are generated by posttranscriptional processing of an extended primary transcript. For almost all RNAs, 3'-end processing consists of two steps: (i) the mRNA is first ...
  • mRNA Capping, organism-specific biosystem (from REACTOME)
    mRNA Capping, organism-specific biosystemThe 5'-ends of all eukaryotic pre-mRNAs studied thus far are converted to cap structures. The cap is thought to influence splicing of the first intron, and is bound by 'cap-binding' proteins, CBP80 a...
  • mRNA Processing, organism-specific biosystem (from WikiPathways)
    mRNA Processing, organism-specific biosystemThis process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA). The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' po...
  • mRNA Splicing, organism-specific biosystem (from REACTOME)
    mRNA Splicing, organism-specific biosystemThe process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, is called mRNA splicing...
  • mRNA Splicing - Major Pathway, organism-specific biosystem (from REACTOME)
    mRNA Splicing - Major Pathway, organism-specific biosystemThe splicing of pre-mRNA occurs within a large, very dynamic complex, designated the 'spliceosome'. The 50-60S spliceosomes are estimated to be 40-60 nm in diameter, and have molecular weights in the...
  • mRNA Splicing - Minor Pathway, organism-specific biosystem (from REACTOME)
    mRNA Splicing - Minor Pathway, organism-specific biosystemThe splicing of a subset of pre-mRNA introns occurs by a second pathway, designated the AT-AC or U12-dependent splicing pathway. AT-AC introns have highly conserved, non-canonical splice sites that ...
  • mRNA surveillance pathway, organism-specific biosystem (from KEGG)
    mRNA surveillance pathway, organism-specific biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...
  • mRNA surveillance pathway, conserved biosystem (from KEGG)
    mRNA surveillance pathway, conserved biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...
  • snRNP Assembly, organism-specific biosystem (from REACTOME)
    snRNP Assembly, organism-specific biosystemSmall nuclear ribonucleoproteins (snRNPs) are crucial for pre-mRNA processing to mRNAs. Each snRNP contains a small nuclear RNA (snRNA) and an extremely stable core of seven Sm proteins. The U6 snRNA...

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC2087

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA 7-methylguanosine cap binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
RNA binding HDA PubMed 
RNA cap binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
7-methylguanosine mRNA capping IDA
Inferred from Direct Assay
more info
 PubMed 
7-methylguanosine mRNA capping TAS
Traceable Author Statement
more info
  
RNA catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
RNA export from nucleus TAS
Traceable Author Statement
more info
  
RNA metabolic process TAS
Traceable Author Statement
more info
  
RNA splicing TAS
Traceable Author Statement
more info
 PubMed 
fibroblast growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
  
gene silencing by RNA IEA
Inferred from Electronic Annotation
more info
  
histone mRNA metabolic process TAS
Traceable Author Statement
more info
  
mRNA 3'-end processing TAS
Traceable Author Statement
more info
  
mRNA cis splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
mRNA export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
mRNA export from nucleus TAS
Traceable Author Statement
more info
  
mRNA splicing, via spliceosome TAS
Traceable Author Statement
more info
  
nuclear export TAS
Traceable Author Statement
more info
  
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IDA
Inferred from Direct Assay
more info
 PubMed 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IMP
Inferred from Mutant Phenotype
more info
 PubMed 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
Traceable Author Statement
more info
  
positive regulation of RNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
positive regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
positive regulation of mRNA 3'-end processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
positive regulation of mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
pre-mRNA cleavage required for polyadenylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT regulation of mRNA polyadenylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
regulation of mRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
regulation of translational initiation IDA
Inferred from Direct Assay
more info
 PubMed 
snRNA transcription by RNA polymerase II TAS
Traceable Author Statement
more info
  
spliceosomal complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
termination of RNA polymerase II transcription TAS
Traceable Author Statement
more info
  
transcription by RNA polymerase II TAS
Traceable Author Statement
more info
  
transcription elongation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
  
Component Evidence Code Pubs
RNA cap binding complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
RNA cap binding complex TAS
Traceable Author Statement
more info
 PubMed 
cytosol IDA
Inferred from Direct Assay
more info
  
cytosol TAS
Traceable Author Statement
more info
  
mRNA cap binding complex IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
mRNA cap binding complex IDA
Inferred from Direct Assay
more info
 PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
  
nuclear cap binding complex IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
  
nucleoplasm TAS
Traceable Author Statement
more info
  
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
nuclear cap-binding protein subunit 1
Names
80 kDa nuclear cap-binding protein
NCBP 80 kDa subunit
nuclear cap binding protein subunit 1, 80kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001351504.1 → NP_001338433.1  nuclear cap-binding protein subunit 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL445531, BC001450, CA418527, DA885233, DB086376
    Conserved Domains (3) summary
    smart00543
    Location:9 → 173
    MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
    pfam09088
    Location:284 → 403
    MIF4G_like; MIF4G like
    pfam09090
    Location:418 → 692
    MIF4G_like_2; MIF4G like

  2. NM_001351505.1 → NP_001338434.1  nuclear cap-binding protein subunit 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL445531, BC001450, CA418527, CN266899, DB086376
    Conserved Domains (2) summary
    pfam09088
    Location:161 → 280
    MIF4G_like; MIF4G like
    pfam09090
    Location:295 → 569
    MIF4G_like_2; MIF4G like

  3. NM_001351506.1 → NP_001338435.1  nuclear cap-binding protein subunit 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL445531, BC001450, CA418527, CN266899, DA885233, DB086376
    Conserved Domains (2) summary
    pfam09088
    Location:161 → 280
    MIF4G_like; MIF4G like
    pfam09090
    Location:295 → 569
    MIF4G_like_2; MIF4G like

  4. NM_001351507.1 → NP_001338436.1  nuclear cap-binding protein subunit 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL445531, BC001450, CA418527, DB086376
    Conserved Domains (2) summary
    pfam09088
    Location:2 → 100
    MIF4G_like; MIF4G like
    pfam09090
    Location:115 → 389
    MIF4G_like_2; MIF4G like

  5. NM_002486.5 → NP_002477.1  nuclear cap-binding protein subunit 1 isoform 1

    See identical proteins and their annotated locations for NP_002477.1

    Status: REVIEWED

    Source sequence(s)
    AL445531, BC001450, CA418527
    Consensus CDS
    CCDS6728.1
    UniProtKB/Swiss-Prot
    Q09161
    UniProtKB/TrEMBL
    A0A024R179
    Related
    ENSP00000364289.3, ENST00000375147.8
    Conserved Domains (3) summary
    smart00543
    Location:28 → 240
    MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
    pfam09088
    Location:351 → 470
    MIF4G_like; MIF4G like
    pfam09090
    Location:485 → 759
    MIF4G_like_2; MIF4G like

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    97633423..97673748
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q09161.1 GenPept UniProtKB/Swiss-Prot:Q09161

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