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NCBP1 nuclear cap binding protein subunit 1 [ Homo sapiens (human) ]

Gene ID: 4686, updated on 6-Jul-2025
Official Symbol
NCBP1provided by HGNC
Official Full Name
nuclear cap binding protein subunit 1provided by HGNC
Primary source
HGNC:HGNC:7658
See related
Ensembl:ENSG00000136937 MIM:600469; AllianceGenome:HGNC:7658
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NCBP; Sto1; CBP80
Summary
The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein promotes high-affinity mRNA-cap binding and associates with the CTD of RNA polymerase II. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 9.3), lymph node (RPKM 7.9) and 25 other tissues See more
Orthologs
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See NCBP1 in Genome Data Viewer
Location:
9q22.33
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (97633821..97673748)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (109805762..109845689)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (100396103..100436030)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:100278102-100278602 Neighboring gene TMOD1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28665 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28666 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:100293128-100293286 Neighboring gene tropomodulin 1 Neighboring gene Sharpr-MPRA regulatory region 7780 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:100318031-100318532 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:100319241-100319742 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28667 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28668 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:100335093-100335332 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28669 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28670 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28671 Neighboring gene Sharpr-MPRA regulatory region 9871 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:100396128-100396963 Neighboring gene thiosulfate sulfurtransferase like domain containing 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28674 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28675 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28676 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20102 Neighboring gene XPA, DNA damage recognition and repair factor Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:100465986-100467185 Neighboring gene keratin 18 pseudogene 13 Neighboring gene papillary thyroid carcinoma susceptibility candidate 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28678 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:100520047-100521246 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr9:100534165-100534666 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr9:100534667-100535166 Neighboring gene VISTA enhancer hs1595 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20103 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:100571176-100572375 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:100589760-100589981 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:100613975-100614476 Neighboring gene forkhead box E1

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EBI GWAS Catalog

Description
The FOXE1 locus is a major genetic determinant for radiation-related thyroid carcinoma in Chernobyl.
EBI GWAS Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • MGC2087

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA 7-methylguanosine cap binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables RNA binding HDA PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding TAS
Traceable Author Statement
more info
PubMed 
enables RNA cap binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA cap binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA cap binding TAS
Traceable Author Statement
more info
PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables molecular adaptor activity EXP
Inferred from Experiment
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in 7-methylguanosine mRNA capping IDA
Inferred from Direct Assay
more info
PubMed 
involved_in 7-methylguanosine mRNA capping IEA
Inferred from Electronic Annotation
more info
 
involved_in RNA catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in RNA metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
 
involved_in RNA splicing TAS
Traceable Author Statement
more info
PubMed 
involved_in alternative mRNA splicing, via spliceosome NAS
Non-traceable Author Statement
more info
PubMed 
involved_in cap-dependent translational initiation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in defense response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in histone mRNA metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in histone mRNA metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mRNA 3'-end processing NAS
Non-traceable Author Statement
more info
PubMed 
involved_in mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mRNA export from nucleus IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mRNA export from nucleus IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in mRNA metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA splicing, via spliceosome NAS
Non-traceable Author Statement
more info
PubMed 
involved_in mRNA transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mRNA transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
PubMed 
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
 
involved_in miRNA-mediated post-transcriptional gene silencing NAS
Non-traceable Author Statement
more info
PubMed 
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
Inferred from Electronic Annotation
more info
 
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of RNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of mRNA 3'-end processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription elongation by RNA polymerase II NAS
Non-traceable Author Statement
more info
PubMed 
involved_in primary miRNA processing NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of mRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of translational initiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulatory ncRNA-mediated gene silencing IEA
Inferred from Electronic Annotation
more info
 
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing NAS
Non-traceable Author Statement
more info
PubMed 
involved_in snRNA export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in snRNA export from nucleus NAS
Non-traceable Author Statement
more info
PubMed 
involved_in spliceosomal complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of RNA cap binding complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of RNA cap binding complex TAS
Traceable Author Statement
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 
part_of nuclear cap binding complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of nuclear cap binding complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of nuclear cap binding complex IEA
Inferred from Electronic Annotation
more info
 
part_of nuclear cap binding complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
nuclear cap-binding protein subunit 1
Names
80 kDa nuclear cap-binding protein
NCBP 80 kDa subunit
nuclear cap binding protein subunit 1, 80kDa

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001351504.2NP_001338433.1  nuclear cap-binding protein subunit 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL445531, BC001450, CA418527, DA885233
    Conserved Domains (3) summary
    smart00543
    Location:9173
    MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
    pfam09088
    Location:284403
    MIF4G_like; MIF4G like
    pfam09090
    Location:418693
    MIF4G_like_2; MIF4G like
  2. NM_001351505.2NP_001338434.1  nuclear cap-binding protein subunit 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL445531, BC001450, CA418527, CN266899
    Conserved Domains (2) summary
    pfam09088
    Location:161280
    MIF4G_like; MIF4G like
    pfam09090
    Location:295570
    MIF4G_like_2; MIF4G like
  3. NM_001351506.2NP_001338435.1  nuclear cap-binding protein subunit 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL445531, BC001450, CA418527, CN266899, DA885233
    Conserved Domains (2) summary
    pfam09088
    Location:161280
    MIF4G_like; MIF4G like
    pfam09090
    Location:295570
    MIF4G_like_2; MIF4G like
  4. NM_001351507.2NP_001338436.1  nuclear cap-binding protein subunit 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL445531, BC001450, CA418527
    Conserved Domains (2) summary
    pfam09088
    Location:2100
    MIF4G_like; MIF4G like
    pfam09090
    Location:115389
    MIF4G_like_2; MIF4G like
  5. NM_002486.5NP_002477.1  nuclear cap-binding protein subunit 1 isoform 1

    See identical proteins and their annotated locations for NP_002477.1

    Status: REVIEWED

    Source sequence(s)
    AL445531, BC001450, CA418527
    Consensus CDS
    CCDS6728.1
    UniProtKB/Swiss-Prot
    B2R718, Q09161, Q59G76, Q5T1V0, Q5T7X2
    Related
    ENSP00000364289.3, ENST00000375147.8
    Conserved Domains (3) summary
    smart00543
    Location:28240
    MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
    pfam09088
    Location:351470
    MIF4G_like; MIF4G like
    pfam09090
    Location:485760
    MIF4G_like_2; MIF4G like

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    97633821..97673748
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    109805762..109845689
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)