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NUBP1 nucleotide binding protein 1 [ Homo sapiens (human) ]

Gene ID: 4682, updated on 11-Sep-2019

Summary

Official Symbol
NUBP1provided by HGNC
Official Full Name
nucleotide binding protein 1provided by HGNC
Primary source
HGNC:HGNC:8041
See related
Ensembl:ENSG00000103274 MIM:600280
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NBP; NBP1; CIAO5; NBP35
Summary
NUBP1 is a member of the NUBP/MRP subfamily of ATP-binding proteins (Nakashima et al., 1999 [PubMed 10486206]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in adrenal (RPKM 9.0), heart (RPKM 8.6) and 25 other tissues See more
Orthologs

Genomic context

See NUBP1 in Genome Data Viewer
Location:
16p13.13
Exon count:
11
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (10743164..10769351)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (10837643..10863208)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene MT-ND4L pseudogene 24 Neighboring gene MT-ND4 pseudogene 34 Neighboring gene trans-golgi network vesicle protein 23 homolog A Neighboring gene uncharacterized LOC105371080 Neighboring gene Rho GTPase activating protein 21 pseudogene Neighboring gene class II major histocompatibility complex transactivator

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Cytosolic iron-sulfur cluster assembly, organism-specific biosystem (from REACTOME)
    Cytosolic iron-sulfur cluster assembly, organism-specific biosystemIron-sulfur clusters containing 4 atoms of iron and 4 atoms of sulfur (4Fe-4S clusters) are assembled in the cytosol on a heterotetrameric scaffold composed of NUBP2 and NUBP1 subunits (reviewed in L...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC117406, MGC130052, MGC130053

Gene Ontology Provided by GOA

Function Evidence Code Pubs
4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
iron-sulfur cluster binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
iron-sulfur cluster binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell projection organization IEA
Inferred from Electronic Annotation
more info
 
cellular iron ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
centrosome localization IEA
Inferred from Electronic Annotation
more info
 
iron-sulfur cluster assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
iron-sulfur cluster assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of centrosome duplication IEA
Inferred from Electronic Annotation
more info
 
protein localization to cell cortex IEA
Inferred from Electronic Annotation
more info
 
regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
centriole IEA
Inferred from Electronic Annotation
more info
 
cilium IEA
Inferred from Electronic Annotation
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
cytosolic Fe-S cluster assembly factor NUBP1
Names
NBP 1
nucleotide binding protein (e.coli MinD like)
nucleotide binding protein 1 (E.coli MinD like)
nucleotide binding protein 1 (MinD homolog, E. coli)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278506.1NP_001265435.1  cytosolic Fe-S cluster assembly factor NUBP1 isoform 2

    See identical proteins and their annotated locations for NP_001265435.1

    Status: VALIDATED

    Source sequence(s)
    AK223204, BC100290, BP225034
    Consensus CDS
    CCDS61839.1
    UniProtKB/Swiss-Prot
    P53384
    Related
    ENSP00000409654.2, ENST00000433392.6
    Conserved Domains (1) summary
    pfam10609
    Location:53292
    ParA; NUBPL iron-transfer P-loop NTPase
  2. NM_001323594.1NP_001310523.1  cytosolic Fe-S cluster assembly factor NUBP1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC074136
  3. NM_001323595.1NP_001310524.1  cytosolic Fe-S cluster assembly factor NUBP1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC074136
    Conserved Domains (2) summary
    COG0489
    Location:38273
    Mrp; Chromosome partitioning ATPase, Mrp family, contains Fe-S cluster [Cell cycle control, cell division, chromosome partitioning]
    pfam10609
    Location:53273
    ParA; NUBPL iron-transfer P-loop NTPase
  4. NM_001323596.1NP_001310525.1  cytosolic Fe-S cluster assembly factor NUBP1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC074136
  5. NM_001323597.1NP_001310526.1  cytosolic Fe-S cluster assembly factor NUBP1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC074136
  6. NM_002484.4NP_002475.2  cytosolic Fe-S cluster assembly factor NUBP1 isoform 1

    See identical proteins and their annotated locations for NP_002475.2

    Status: VALIDATED

    Source sequence(s)
    AK223204, BP225034
    Consensus CDS
    CCDS10543.1
    UniProtKB/Swiss-Prot
    P53384
    Related
    ENSP00000283027.5, ENST00000283027.10
    Conserved Domains (2) summary
    TIGR01969
    Location:57303
    minD_arch; cell division ATPase MinD, archaeal
    pfam10609
    Location:53303
    ParA; NUBPL iron-transfer P-loop NTPase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    10743164..10769351
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017023252.1XP_016878741.1  cytosolic Fe-S cluster assembly factor NUBP1 isoform X1

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