Format

Send to:

Choose Destination

CEACAM6 CEA cell adhesion molecule 6 [ Homo sapiens (human) ]

Gene ID: 4680, updated on 17-Apr-2020

Summary

Official Symbol
CEACAM6provided by HGNC
Official Full Name
CEA cell adhesion molecule 6provided by HGNC
Primary source
HGNC:HGNC:1818
See related
Ensembl:ENSG00000086548 MIM:163980
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NCA; CEAL; CD66c
Summary
This gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. Members of this family play a role in cell adhesion and are widely used as tumor markers in serum immunoassay determinations of carcinoma. This gene affects the sensitivity of tumor cells to adenovirus infection. The protein encoded by this gene acts as a receptor for adherent-invasive E. coli adhesion to the surface of ileal epithelial cells in patients with Crohn's disease. This gene is clustered with genes and pseudogenes of the cell adhesion molecules subgroup of the CEA family on chromosome 19. [provided by RefSeq, Apr 2014]
Expression
Biased expression in colon (RPKM 147.4), lung (RPKM 142.2) and 9 other tissues See more
Orthologs

Genomic context

See CEACAM6 in Genome Data Viewer
Location:
19q13.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (41755529..41772211)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (42259398..42276113)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene CEA cell adhesion molecule 7 Neighboring gene CEA cell adhesion molecule 5 Neighboring gene uncharacterized LOC112268252 Neighboring gene CEA cell adhesion molecule 1 pseudogene Neighboring gene CEA cell adhesion molecule 3 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 52

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
anchored component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
azurophil granule membrane TAS
Traceable Author Statement
more info
 
cell surface IC
Inferred by Curator
more info
PubMed 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
carcinoembryonic antigen-related cell adhesion molecule 6
Names
Cluster of Differentiation 66c
carcinoembryonic antigen related cell adhesion molecule 6
carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
normal cross-reacting antigen

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002483.7NP_002474.4  carcinoembryonic antigen-related cell adhesion molecule 6 preproprotein

    See identical proteins and their annotated locations for NP_002474.4

    Status: REVIEWED

    Source sequence(s)
    AC243967, AK312542, BC005008, DA763751, M18728
    Consensus CDS
    CCDS12585.1
    UniProtKB/Swiss-Prot
    P40199
    Related
    ENSP00000199764.6, ENST00000199764.7
    Conserved Domains (4) summary
    cd05774
    Location:36140
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:244312
    IG_like; Immunoglobulin like
    pfam13895
    Location:240318
    Ig_2; Immunoglobulin domain
    cl11960
    Location:146234
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    41755529..41772211
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526990.2XP_011525292.1  carcinoembryonic antigen-related cell adhesion molecule 6 isoform X1

    See identical proteins and their annotated locations for XP_011525292.1

    Conserved Domains (4) summary
    cd05774
    Location:36140
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:244312
    IG_like; Immunoglobulin like
    pfam13895
    Location:240318
    Ig_2; Immunoglobulin domain
    cl11960
    Location:146234
    Ig; Immunoglobulin domain
Support Center