Format

Send to:

Choose Destination

NAP1L4 nucleosome assembly protein 1 like 4 [ Homo sapiens (human) ]

Gene ID: 4676, updated on 4-May-2020

Summary

Official Symbol
NAP1L4provided by HGNC
Official Full Name
nucleosome assembly protein 1 like 4provided by HGNC
Primary source
HGNC:HGNC:7640
See related
Ensembl:ENSG00000205531 MIM:601651
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NAP2; NAP2L; hNAP2; NAP1L4b
Summary
This gene encodes a member of the nucleosome assembly protein (NAP) family which can interact with both core and linker histones. It can shuttle between the cytoplasm and nucleus, suggesting a role as a histone chaperone. This gene is one of several located near the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 52.4), heart (RPKM 37.7) and 25 other tissues See more
Orthologs

Genomic context

See NAP1L4 in Genome Data Viewer
Location:
11p15.4
Exon count:
21
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (2944437..2992329, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (2965660..3013607, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene solute carrier family 22 member 18 antisense Neighboring gene solute carrier family 22 member 18 Neighboring gene pleckstrin homology like domain family A member 2 Neighboring gene small nucleolar RNA, H/ACA box 54 Neighboring gene Sharpr-MPRA regulatory region 13774 Neighboring gene cysteinyl-tRNA synthetase 1 Neighboring gene CARS1 antisense RNA 1 Neighboring gene RNA, U1 small nuclear 91, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 modulates expression of the chemokines, GRO-alpha (CXCL1), GRO-gamma, NAP2, IL-8, IP-10, MIP-1beta, MIP-1alpha, RANTES, and MIP-3alpha, in PBMCs and MDMs PubMed
Rev rev HIV-1 Rev interacting protein, nucleosome assembly protein 1-like 4 (NAP1L4), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with NAP1L4 is decreased by RRE PubMed
Tat tat HIV-1 Tat is identified to have a physical interaction with nucleosome assembly protein 1-like 4 (NAP1L4) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC4565

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleosome binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
unfolded protein binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleosome assembly IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
nucleosome assembly protein 1-like 4
Names
NAP-2
nucleosome assembly protein 1-like 4b
nucleosome assembly protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001369375.1NP_001356304.1  nucleosome assembly protein 1-like 4 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC131971
    Conserved Domains (1) summary
    pfam00956
    Location:67337
    NAP; Nucleosome assembly protein (NAP)
  2. NM_001369376.1NP_001356305.1  nucleosome assembly protein 1-like 4 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC131971
    Conserved Domains (1) summary
    pfam00956
    Location:67337
    NAP; Nucleosome assembly protein (NAP)
  3. NM_001369377.1NP_001356306.1  nucleosome assembly protein 1-like 4 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC131971
    Conserved Domains (1) summary
    pfam00956
    Location:67337
    NAP; Nucleosome assembly protein (NAP)
  4. NM_001369378.1NP_001356307.1  nucleosome assembly protein 1-like 4 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC131971
    Conserved Domains (1) summary
    pfam00956
    Location:67337
    NAP; Nucleosome assembly protein (NAP)
  5. NM_001369379.1NP_001356308.1  nucleosome assembly protein 1-like 4 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC131971
    Conserved Domains (1) summary
    pfam00956
    Location:67337
    NAP; Nucleosome assembly protein (NAP)
  6. NM_001369380.1NP_001356309.1  nucleosome assembly protein 1-like 4 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC131971
    Related
    ENSP00000481412.1, ENST00000620138.4
    Conserved Domains (1) summary
    pfam00956
    Location:67337
    NAP; Nucleosome assembly protein (NAP)
  7. NM_001369381.1NP_001356310.1  nucleosome assembly protein 1-like 4 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC131971
    Related
    ENSP00000436397.1, ENST00000526115.5
    Conserved Domains (1) summary
    pfam00956
    Location:67337
    NAP; Nucleosome assembly protein (NAP)
  8. NM_001369382.1NP_001356311.1  nucleosome assembly protein 1-like 4 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC131971
    Conserved Domains (1) summary
    pfam00956
    Location:67337
    NAP; Nucleosome assembly protein (NAP)
  9. NM_001369383.1NP_001356312.1  nucleosome assembly protein 1-like 4 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC131971
    Conserved Domains (1) summary
    pfam00956
    Location:67337
    NAP; Nucleosome assembly protein (NAP)
  10. NM_001369384.1NP_001356313.1  nucleosome assembly protein 1-like 4 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC131971
    Conserved Domains (1) summary
    pfam00956
    Location:67337
    NAP; Nucleosome assembly protein (NAP)
  11. NM_001369385.1NP_001356314.1  nucleosome assembly protein 1-like 4 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC131971
    Conserved Domains (1) summary
    pfam00956
    Location:67337
    NAP; Nucleosome assembly protein (NAP)
  12. NM_001369386.1NP_001356315.1  nucleosome assembly protein 1-like 4 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC131971
    Conserved Domains (1) summary
    pfam00956
    Location:67337
    NAP; Nucleosome assembly protein (NAP)
  13. NM_001369388.1NP_001356317.1  nucleosome assembly protein 1-like 4 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC131971
    Conserved Domains (1) summary
    pfam00956
    Location:67337
    NAP; Nucleosome assembly protein (NAP)
  14. NM_005969.4NP_005960.1  nucleosome assembly protein 1-like 4

    See identical proteins and their annotated locations for NP_005960.1

    Status: REVIEWED

    Source sequence(s)
    AA573896, BC022090, U77456
    Consensus CDS
    CCDS41599.1
    UniProtKB/Swiss-Prot
    Q99733
    UniProtKB/TrEMBL
    A0A024RCC9
    Related
    ENSP00000369915.4, ENST00000380542.9
    Conserved Domains (1) summary
    pfam00956
    Location:67337
    NAP; Nucleosome assembly protein (NAP)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    2944437..2992329 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187585.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    175485..223399 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center