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HNRNPM heterogeneous nuclear ribonucleoprotein M [ Homo sapiens (human) ]

Gene ID: 4670, updated on 1-Jun-2020

Summary

Official Symbol
HNRNPMprovided by HGNC
Official Full Name
heterogeneous nuclear ribonucleoprotein Mprovided by HGNC
Primary source
HGNC:HGNC:5046
See related
Ensembl:ENSG00000099783 MIM:160994
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CEAR; HNRPM; HTGR1; NAGR1; HNRPM4; HNRNPM4; hnRNP M
Summary
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs. This protein also constitutes a monomer of the N-acetylglucosamine-specific receptor which is postulated to trigger selective recycling of immature GlcNAc-bearing thyroglobulin molecules. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Expression
Ubiquitous expression in bone marrow (RPKM 50.0), colon (RPKM 44.6) and 25 other tissues See more
Orthologs

Genomic context

See HNRNPM in Genome Data Viewer
Location:
19p13.2
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (8444575..8489114)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (8509460..8554002)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene RAB11B antisense RNA 1 Neighboring gene RAB11B, member RAS oncogene family Neighboring gene GATA motif-containing MPRA enhancer 154 Neighboring gene membrane associated ring-CH-type finger 2 Neighboring gene PML-RARA regulated adaptor molecule 1 Neighboring gene zinc finger protein 414

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein M (HNRNPM ), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein M (HNRNPM ), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein M (HNRNPM ), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Cellular biotinylated heterogeneous nuclear ribonucleoprotein M (HNRNPM) is incorporated into HIV-1 Gag virus-like particles PubMed
gag Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein M (HNRNPM ), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Rev rev HIV-1 Rev interacting protein, heterogeneous nuclear ribonucleoprotein M (HNRNPM), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with HNRNPM is increased by RRE PubMed
Tat tat Heterogeneous nuclear ribonucleoprotein M (HNRNPM) is identified to interact with HIV-1 Tat mutant Nullbasic in HeLa cells by LC MS/MS PubMed
integrase gag-pol Analysis of HIV-1 proviral integration sites in antiretroviral treatment patients indicates that HNRNPM gene favors HIV-1 integration for expansion and persistence of infected cells, suggesting HIV-1 IN interacts with HNRNPM PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp547H118

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA binding NAS
Non-traceable Author Statement
more info
PubMed 
mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
RNA metabolic process TAS
Traceable Author Statement
more info
 
alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
alternative mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
fibroblast growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
mRNA splicing, via spliceosome IC
Inferred by Curator
more info
PubMed 
mRNA splicing, via spliceosome TAS
Traceable Author Statement
more info
 
regulation of mRNA stability involved in response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
collagen-containing extracellular matrix HDA PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular exosome HDA PubMed 
membrane HDA PubMed 
nuclear matrix IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
paraspeckles IDA
Inferred from Direct Assay
more info
PubMed 
post-mRNA release spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spliceosomal complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
heterogeneous nuclear ribonucleoprotein M
Names
CEA receptor
N-acetylglucosamine receptor 1
heterogenous nuclear ribonucleoprotein M4
hnRNA-binding protein M4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029850.1 RefSeqGene

    Range
    5057..49196
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001297418.2NP_001284347.1  heterogeneous nuclear ribonucleoprotein M isoform c

    See identical proteins and their annotated locations for NP_001284347.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform c, which has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AA244120, AB209733, CN350481, CN350526, HY007201
    UniProtKB/TrEMBL
    Q59ES8
    Conserved Domains (4) summary
    cd12386
    Location:86159
    RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
    cd12661
    Location:519595
    RRM3_hnRNPM; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
    cl17169
    Location:127
    RRM_SF; RNA recognition motif (RRM) superfamily
    cl25887
    Location:82236
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
  2. NM_005968.5NP_005959.2  heterogeneous nuclear ribonucleoprotein M isoform a

    See identical proteins and their annotated locations for NP_005959.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    BC000138, CN350526
    Consensus CDS
    CCDS12203.1
    UniProtKB/Swiss-Prot
    P52272
    Related
    ENSP00000325376.2, ENST00000325495.9
    Conserved Domains (5) summary
    cd12386
    Location:206279
    RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
    cd12657
    Location:72147
    RRM1_hnRNPM; RNA recognition motif 1 in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
    cd12661
    Location:654730
    RRM3_hnRNPM; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
    pfam09606
    Location:385603
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam11532
    Location:4270
    HnRNP_M; Heterogeneous nuclear ribonucleoprotein M
  3. NM_031203.4NP_112480.2  heterogeneous nuclear ribonucleoprotein M isoform b

    See identical proteins and their annotated locations for NP_112480.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame segment in the coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.
    Source sequence(s)
    BC008895, BC058893, CN350526, DB478004
    Consensus CDS
    CCDS12204.1
    UniProtKB/Swiss-Prot
    P52272
    Related
    ENSP00000325732.2, ENST00000348943.7
    Conserved Domains (5) summary
    cd12386
    Location:167240
    RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
    cd12661
    Location:615691
    RRM3_hnRNPM; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
    pfam09606
    Location:346564
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam11532
    Location:4270
    HnRNP_M; Heterogeneous nuclear ribonucleoprotein M
    cl17169
    Location:72147
    RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    8444575..8489114
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005272479.2XP_005272536.1  heterogeneous nuclear ribonucleoprotein M isoform X2

    See identical proteins and their annotated locations for XP_005272536.1

    Conserved Domains (4) summary
    cd12386
    Location:206279
    RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
    cd12657
    Location:72147
    RRM1_hnRNPM; RNA recognition motif 1 in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
    cd12661
    Location:636712
    RRM3_hnRNPM; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
    pfam11532
    Location:4270
    HnRNP_M; Heterogeneous nuclear ribonucleoprotein M
  2. XM_017026823.1XP_016882312.1  heterogeneous nuclear ribonucleoprotein M isoform X3

    Conserved Domains (5) summary
    COG0724
    Location:622697
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12386
    Location:206279
    RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
    cd12657
    Location:72147
    RRM1_hnRNPM; RNA recognition motif 1 in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
    cd12661
    Location:621697
    RRM3_hnRNPM; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
    pfam11532
    Location:4170
    HnRNP_M; Heterogeneous nuclear ribonucleoprotein M
  3. XM_017026824.1XP_016882313.1  heterogeneous nuclear ribonucleoprotein M isoform X5

    Conserved Domains (4) summary
    cd12386
    Location:167240
    RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
    cd12661
    Location:597673
    RRM3_hnRNPM; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
    pfam11532
    Location:4270
    HnRNP_M; Heterogeneous nuclear ribonucleoprotein M
    cl17169
    Location:72147
    RRM_SF; RNA recognition motif (RRM) superfamily
  4. XM_005272480.2XP_005272537.1  heterogeneous nuclear ribonucleoprotein M isoform X4

    See identical proteins and their annotated locations for XP_005272537.1

    Conserved Domains (5) summary
    COG0724
    Location:601676
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12386
    Location:167240
    RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
    cd12661
    Location:600676
    RRM3_hnRNPM; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
    pfam11532
    Location:4170
    HnRNP_M; Heterogeneous nuclear ribonucleoprotein M
    cl17169
    Location:72147
    RRM_SF; RNA recognition motif (RRM) superfamily
  5. XM_017026825.1XP_016882314.1  heterogeneous nuclear ribonucleoprotein M isoform X6

  6. XM_005272481.1XP_005272538.1  heterogeneous nuclear ribonucleoprotein M isoform X7

    See identical proteins and their annotated locations for XP_005272538.1

    Conserved Domains (4) summary
    COG0724
    Location:535610
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12386
    Location:86159
    RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
    cd12661
    Location:534610
    RRM3_hnRNPM; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
    cl17169
    Location:127
    RRM_SF; RNA recognition motif (RRM) superfamily
  7. XM_017026827.1XP_016882316.1  heterogeneous nuclear ribonucleoprotein M isoform X9

  8. XM_017026829.1XP_016882318.1  heterogeneous nuclear ribonucleoprotein M isoform X12

  9. XM_017026830.1XP_016882319.1  heterogeneous nuclear ribonucleoprotein M isoform X13

  10. XM_005272483.2XP_005272540.1  heterogeneous nuclear ribonucleoprotein M isoform X10

    See identical proteins and their annotated locations for XP_005272540.1

    Conserved Domains (4) summary
    COG0724
    Location:496571
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12386
    Location:47120
    RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
    cd12661
    Location:495571
    RRM3_hnRNPM; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
    cl17169
    Location:127
    RRM_SF; RNA recognition motif (RRM) superfamily
  11. XM_005272478.3XP_005272535.1  heterogeneous nuclear ribonucleoprotein M isoform X1

    See identical proteins and their annotated locations for XP_005272535.1

    Conserved Domains (5) summary
    COG0724
    Location:640715
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12386
    Location:206279
    RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
    cd12657
    Location:72147
    RRM1_hnRNPM; RNA recognition motif 1 in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
    cd12661
    Location:639715
    RRM3_hnRNPM; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
    pfam11532
    Location:4170
    HnRNP_M; Heterogeneous nuclear ribonucleoprotein M
  12. XM_017026828.1XP_016882317.1  heterogeneous nuclear ribonucleoprotein M isoform X11

    Conserved Domains (3) summary
    TIGR01628
    Location:3197
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12386
    Location:47120
    RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
    cd12661
    Location:480556
    RRM3_hnRNPM; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
  13. XM_017026826.1XP_016882315.1  heterogeneous nuclear ribonucleoprotein M isoform X8

  14. XM_017026831.1XP_016882320.1  heterogeneous nuclear ribonucleoprotein M isoform X14

  15. XM_017026832.1XP_016882321.1  heterogeneous nuclear ribonucleoprotein M isoform X15

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