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ATF1 activating transcription factor 1 [ Homo sapiens (human) ]

Gene ID: 466, updated on 27-Nov-2022

Summary

Official Symbol
ATF1provided by HGNC
Official Full Name
activating transcription factor 1provided by HGNC
Primary source
HGNC:HGNC:783
See related
Ensembl:ENSG00000123268 MIM:123803; AllianceGenome:HGNC:783
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TREB36; EWS-ATF1; FUS/ATF-1
Summary
This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6. [provided by RefSeq, Aug 2010]
Expression
Ubiquitous expression in thyroid (RPKM 6.8), adrenal (RPKM 5.9) and 25 other tissues See more
Orthologs
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Genomic context

See ATF1 in Genome Data Viewer
Location:
12q13.12
Exon count:
12
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (50763459..50821162)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (50727262..50784323)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (51157884..51214945)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene disco interacting protein 2 homolog B Neighboring gene RNA, U6 small nuclear 238, pseudogene Neighboring gene uncharacterized LOC124902932 Neighboring gene RNA, 7SL, cytoplasmic 519, pseudogene Neighboring gene transmembrane serine protease 12

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease.
EBI GWAS Catalog
Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis.
EBI GWAS Catalog
Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr activation of activating protein 1-regulated promoters is linked to Vpr regulation of IL-12, CD44, Toll-like receptor 4, indolamine 2,3-dioxygenase, macrophage receptor with collagenous structure, and thrombospondin 1 PubMed
vpr HIV-1 Vpr potentiates the trans-activation, but not the trans-repression, properties of the glucocorticoid receptor on activating protein 1-regulated simple promoters PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
part_of ATF1-ATF4 transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of ATF4-CREB1 transcription factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of RNA polymerase II transcription regulator complex IC
Inferred by Curator
more info
 
part_of RNA polymerase II transcription regulator complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IC
Inferred by Curator
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cyclic AMP-dependent transcription factor ATF-1
Names
cAMP-dependent transcription factor ATF-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027673.1 RefSeqGene

    Range
    5096..62157
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001412960.1NP_001399889.1  cyclic AMP-dependent transcription factor ATF-1 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC013244
  2. NM_001412961.1NP_001399890.1  cyclic AMP-dependent transcription factor ATF-1 isoform b

    Status: REVIEWED

    Source sequence(s)
    AC013244
  3. NM_001412962.1NP_001399891.1  cyclic AMP-dependent transcription factor ATF-1 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC013244
    UniProtKB/Swiss-Prot
    Q9H4A8
  4. NM_001412963.1NP_001399892.1  cyclic AMP-dependent transcription factor ATF-1 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC013244
    UniProtKB/Swiss-Prot
    Q9H4A8
  5. NM_001412964.1NP_001399893.1  cyclic AMP-dependent transcription factor ATF-1 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC013244
    UniProtKB/Swiss-Prot
    Q9H4A8
  6. NM_001412965.1NP_001399894.1  cyclic AMP-dependent transcription factor ATF-1 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC013244
    UniProtKB/Swiss-Prot
    Q9H4A8
  7. NM_001412966.1NP_001399895.1  cyclic AMP-dependent transcription factor ATF-1 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC013244
    UniProtKB/Swiss-Prot
    Q9H4A8
  8. NM_001412967.1NP_001399896.1  cyclic AMP-dependent transcription factor ATF-1 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC013244
    UniProtKB/Swiss-Prot
    Q9H4A8
  9. NM_001412968.1NP_001399897.1  cyclic AMP-dependent transcription factor ATF-1 isoform d

    Status: REVIEWED

    Source sequence(s)
    AC013244
  10. NM_001412969.1NP_001399898.1  cyclic AMP-dependent transcription factor ATF-1 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC013244
  11. NM_001412970.1NP_001399899.1  cyclic AMP-dependent transcription factor ATF-1 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC013244
  12. NM_001412971.1NP_001399900.1  cyclic AMP-dependent transcription factor ATF-1 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC013244
  13. NM_001412972.1NP_001399901.1  cyclic AMP-dependent transcription factor ATF-1 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC013244
  14. NM_001412973.1NP_001399902.1  cyclic AMP-dependent transcription factor ATF-1 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC013244
  15. NM_001412974.1NP_001399903.1  cyclic AMP-dependent transcription factor ATF-1 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC013244
  16. NM_001412975.1NP_001399904.1  cyclic AMP-dependent transcription factor ATF-1 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC013244
  17. NM_001412976.1NP_001399905.1  cyclic AMP-dependent transcription factor ATF-1 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC013244
  18. NM_001412977.1NP_001399906.1  cyclic AMP-dependent transcription factor ATF-1 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC013244
  19. NM_001412978.1NP_001399907.1  cyclic AMP-dependent transcription factor ATF-1 isoform f

    Status: REVIEWED

    Source sequence(s)
    AC013244
  20. NM_001412979.1NP_001399908.1  cyclic AMP-dependent transcription factor ATF-1 isoform f

    Status: REVIEWED

    Source sequence(s)
    AC013244
  21. NM_001412980.1NP_001399909.1  cyclic AMP-dependent transcription factor ATF-1 isoform f

    Status: REVIEWED

    Source sequence(s)
    AC013244
  22. NM_001412981.1NP_001399910.1  cyclic AMP-dependent transcription factor ATF-1 isoform f

    Status: REVIEWED

    Source sequence(s)
    AC013244
  23. NM_001412982.1NP_001399911.1  cyclic AMP-dependent transcription factor ATF-1 isoform f

    Status: REVIEWED

    Source sequence(s)
    AC013244
  24. NM_001412983.1NP_001399912.1  cyclic AMP-dependent transcription factor ATF-1 isoform g

    Status: REVIEWED

    Source sequence(s)
    AC013244
  25. NM_005171.5NP_005162.1  cyclic AMP-dependent transcription factor ATF-1 isoform c

    See identical proteins and their annotated locations for NP_005162.1

    Status: REVIEWED

    Source sequence(s)
    AC013244, DA468394
    Consensus CDS
    CCDS8803.1
    UniProtKB/Swiss-Prot
    P18846, Q9H4A8
    Related
    ENSP00000262053.3, ENST00000262053.8
    Conserved Domains (2) summary
    cd14690
    Location:215269
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:4882
    pKID; pKID domain

RNA

  1. NR_182081.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC013244

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    50763459..50821162
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538387.3XP_011536689.1  cyclic AMP-dependent transcription factor ATF-1 isoform X2

    UniProtKB/Swiss-Prot
    P18846
    Conserved Domains (2) summary
    cd14690
    Location:215269
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:4882
    pKID; pKID domain
  2. XM_047428877.1XP_047284833.1  cyclic AMP-dependent transcription factor ATF-1 isoform X2

  3. XM_017019333.1XP_016874822.1  cyclic AMP-dependent transcription factor ATF-1 isoform X2

    UniProtKB/Swiss-Prot
    P18846
    Conserved Domains (2) summary
    cd14690
    Location:215269
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:4882
    pKID; pKID domain
  4. XM_011538386.3XP_011536688.1  cyclic AMP-dependent transcription factor ATF-1 isoform X2

    See identical proteins and their annotated locations for XP_011536688.1

    UniProtKB/Swiss-Prot
    P18846, Q9H4A8
    Conserved Domains (2) summary
    cd14690
    Location:215269
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:4882
    pKID; pKID domain
  5. XM_017019331.2XP_016874820.1  cyclic AMP-dependent transcription factor ATF-1 isoform X1

  6. XM_017019336.2XP_016874825.1  cyclic AMP-dependent transcription factor ATF-1 isoform X3

    Conserved Domains (1) summary
    cd14690
    Location:121175
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
  7. XM_047428878.1XP_047284834.1  cyclic AMP-dependent transcription factor ATF-1 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    50727262..50784323
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)