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ATF1 activating transcription factor 1 [ Homo sapiens (human) ]

Gene ID: 466, updated on 9-Feb-2020

Summary

Official Symbol
ATF1provided by HGNC
Official Full Name
activating transcription factor 1provided by HGNC
Primary source
HGNC:HGNC:783
See related
Ensembl:ENSG00000123268 MIM:123803
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TREB36; EWS-ATF1; FUS/ATF-1
Summary
This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6. [provided by RefSeq, Aug 2010]
Expression
Ubiquitous expression in thyroid (RPKM 6.8), adrenal (RPKM 5.9) and 25 other tissues See more
Orthologs

Genomic context

See ATF1 in Genome Data Viewer
Location:
12q13.12
Exon count:
13
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (50763682..50821162)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (51157789..51214943)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene disco interacting protein 2 homolog B Neighboring gene RNA, U6 small nuclear 769, pseudogene Neighboring gene RNA, U6 small nuclear 238, pseudogene Neighboring gene RNA, 7SL, cytoplasmic 519, pseudogene Neighboring gene transmembrane serine protease 12

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease.
NHGRI GWA Catalog
Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis.
NHGRI GWA Catalog
Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr activation of activating protein 1-regulated promoters is linked to Vpr regulation of IL-12, CD44, Toll-like receptor 4, indolamine 2,3-dioxygenase, macrophage receptor with collagenous structure, and thrombospondin 1 PubMed
vpr HIV-1 Vpr potentiates the trans-activation, but not the trans-repression, properties of the glucocorticoid receptor on activating protein 1-regulated simple promoters PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cellular protein-containing complex assembly IEA
Inferred from Electronic Annotation
more info
 
positive regulation of DNA replication IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neuron projection development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
response to cobalt ion IEA
Inferred from Electronic Annotation
more info
 
response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
ATF1-ATF4 transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cyclic AMP-dependent transcription factor ATF-1
Names
cAMP-dependent transcription factor ATF-1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027673.1 RefSeqGene

    Range
    5096..62157
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005171.5NP_005162.1  cyclic AMP-dependent transcription factor ATF-1

    See identical proteins and their annotated locations for NP_005162.1

    Status: REVIEWED

    Source sequence(s)
    AC013244, DA468394
    Consensus CDS
    CCDS8803.1
    UniProtKB/Swiss-Prot
    P18846
    Related
    ENSP00000262053.3, ENST00000262053.8
    Conserved Domains (2) summary
    cd14690
    Location:215269
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:4882
    pKID; pKID domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    50763682..50821162
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017019336.1XP_016874825.1  cyclic AMP-dependent transcription factor ATF-1 isoform X3

    Conserved Domains (1) summary
    cd14690
    Location:121175
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
  2. XM_011538387.2XP_011536689.1  cyclic AMP-dependent transcription factor ATF-1 isoform X2

    See identical proteins and their annotated locations for XP_011536689.1

    UniProtKB/Swiss-Prot
    P18846
    Conserved Domains (2) summary
    cd14690
    Location:215269
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:4882
    pKID; pKID domain
  3. XM_011538388.2XP_011536690.1  cyclic AMP-dependent transcription factor ATF-1 isoform X3

    See identical proteins and their annotated locations for XP_011536690.1

    Conserved Domains (1) summary
    cd14690
    Location:121175
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
  4. XM_017019334.1XP_016874823.1  cyclic AMP-dependent transcription factor ATF-1 isoform X2

    UniProtKB/Swiss-Prot
    P18846
    Conserved Domains (2) summary
    cd14690
    Location:215269
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:4882
    pKID; pKID domain
  5. XM_017019333.1XP_016874822.1  cyclic AMP-dependent transcription factor ATF-1 isoform X2

    UniProtKB/Swiss-Prot
    P18846
    Conserved Domains (2) summary
    cd14690
    Location:215269
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:4882
    pKID; pKID domain
  6. XM_017019335.1XP_016874824.1  cyclic AMP-dependent transcription factor ATF-1 isoform X3

    Conserved Domains (1) summary
    cd14690
    Location:121175
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
  7. XM_011538386.2XP_011536688.1  cyclic AMP-dependent transcription factor ATF-1 isoform X2

    See identical proteins and their annotated locations for XP_011536688.1

    UniProtKB/Swiss-Prot
    P18846
    Conserved Domains (2) summary
    cd14690
    Location:215269
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:4882
    pKID; pKID domain
  8. XM_017019332.1XP_016874821.1  cyclic AMP-dependent transcription factor ATF-1 isoform X2

    UniProtKB/Swiss-Prot
    P18846
    Conserved Domains (2) summary
    cd14690
    Location:215269
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:4882
    pKID; pKID domain
  9. XM_017019331.1XP_016874820.1  cyclic AMP-dependent transcription factor ATF-1 isoform X1

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