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A2M alpha-2-macroglobulin [ Pan troglodytes (chimpanzee) ]

Gene ID: 465372, updated on 23-Mar-2018
Official Symbol
A2Mprovided by VGNC
Official Full Name
alpha-2-macroglobulinprovided by VGNC
Primary source
VGNC:VGNC:8309
See related
Ensembl:ENSPTRG00000004650
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
See A2M in Genome Data Viewer
Location:
chromosome: 12
Exon count:
36
Annotation release Status Assembly Chr Location
105 current Clint_PTRv2 (GCF_002880755.1) 12 NC_036891.1 (9260274..9308962, complement)
103 previous assembly Pan_troglodytes-2.1.4 (GCF_000001515.6) 12 NC_006479.3 (9297086..9345736, complement)

Chromosome 12 - NC_036891.1Genomic Context describing neighboring genes Neighboring gene killer cell lectin like receptor G1 Neighboring gene voltage-dependent anion-selective channel protein 2 pseudogene Neighboring gene putative uncharacterized protein encoded by LINC00612 Neighboring gene protein BTG1 pseudogene Neighboring gene translationally-controlled tumor protein-like Neighboring gene PZP, alpha-2-macroglobulin like

  • Project title: Tissue-specific RNA-sequencing for ten non-human primate species
  • Description: Total RNA sequencing of fifteen different tissues for ten non-human primates
  • BioProject: PRJNA271912
  • Publication: PMID 25392405
  • Analysis date: Tue Apr 3 07:13:10 2018

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Complement and coagulation cascades, organism-specific biosystem (from KEGG)
    Complement and coagulation cascades, organism-specific biosystemThe complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a nonspecific defense mechanism against pathogens. There are three pathways of complement activation:...
  • Complement and coagulation cascades, conserved biosystem (from KEGG)
    Complement and coagulation cascades, conserved biosystemThe complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a nonspecific defense mechanism against pathogens. There are three pathways of complement activation:...

Markers

Homology

Preferred Names
alpha-2-macroglobulin-P; alpha-2-macroglobulin

RefSeqs of Annotated Genomes: Pan troglodytes Annotation Release 105 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Clint_PTRv2 Primary Assembly

Genomic

  1. NC_036891.1 Reference Clint_PTRv2 Primary Assembly

    Range
    9260274..9308962 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001139819.5XP_001139819.1  alpha-2-macroglobulin isoform X2

    See identical proteins and their annotated locations for XP_001139819.1

    UniProtKB/TrEMBL
    H2RC06
    Related
    ENSPTRP00000056596.1
    Conserved Domains (5) summary
    cd02897
    Location:9581264
    A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
    pfam00207
    Location:738828
    A2M; Alpha-2-macroglobulin family
    pfam01835
    Location:129221
    A2M_N; MG2 domain
    pfam07677
    Location:13761463
    A2M_recep; A-macroglobulin receptor
    pfam07703
    Location:459607
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region
  2. XM_009424790.1XP_009423065.1  alpha-2-macroglobulin isoform X1

    Conserved Domains (7) summary
    COG2373
    Location:1241071
    YfaS; Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only]
    cd02897
    Location:9581264
    A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
    pfam00207
    Location:738828
    A2M; Alpha-2-macroglobulin family
    pfam01835
    Location:129221
    A2M_N; MG2 domain
    pfam07677
    Location:13761463
    A2M_recep; A-macroglobulin receptor
    pfam07678
    Location:10101266
    A2M_comp; A-macroglobulin complement component
    pfam07703
    Location:461606
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region
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