U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

MYO9A myosin IXA [ Homo sapiens (human) ]

Gene ID: 4649, updated on 22-Sep-2022

Summary

Official Symbol
MYO9Aprovided by HGNC
Official Full Name
myosin IXAprovided by HGNC
Primary source
HGNC:HGNC:7608
See related
Ensembl:ENSG00000066933 MIM:604875; AllianceGenome:HGNC:7608
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CMS24
Summary
This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). Unconventional myosins contain the basic domains of conventional myosins and are further distinguished from class members by their tail domains. They function as actin-based molecular motors. Mutations in this gene have been associated with Bardet-Biedl Syndrome. [provided by RefSeq, Dec 2011]
Expression
Broad expression in testis (RPKM 12.9), thyroid (RPKM 5.9) and 24 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See MYO9A in Genome Data Viewer
Location:
15q23
Exon count:
47
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (71822291..72118600, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (69641241..69934886, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (72114632..72410491, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene thrombospondin type 1 domain containing 4 Neighboring gene THSD4 antisense RNA 2 Neighboring gene RNA, 5S ribosomal pseudogene 399 Neighboring gene nuclear receptor subfamily 2 group E member 3 Neighboring gene uncharacterized LOC107984713 Neighboring gene uncharacterized LOC107984714 Neighboring gene eukaryotic translation initiation factor 5A2 pseudogene 1 Neighboring gene RNA, U2 small nuclear 65, pseudogene Neighboring gene uncharacterized LOC124903522 Neighboring gene Sharpr-MPRA regulatory region 4122 Neighboring gene ribosomal protein L21 pseudogene 115 Neighboring gene SUMO peptidase family member, NEDD8 specific Neighboring gene GRAM domain containing 2A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Congenital myasthenic syndrome Compare labs
Myasthenic syndrome, congenital, 24, presynaptic
MedGen: C4748684 OMIM: 618198 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
EBI GWAS Catalog
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11061, FLJ13244, MGC71859

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activator activity TAS
Traceable Author Statement
more info
 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in actin filament IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in axonal growth cone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in axonal growth cone ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 
part_of unconventional myosin complex NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
unconventional myosin-IXa
Names
myosin-IXa
unconventional myosin-9a

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006901.4NP_008832.2  unconventional myosin-IXa

    See identical proteins and their annotated locations for NP_008832.2

    Status: REVIEWED

    Source sequence(s)
    AC020779, AC022872, AC104938, AF117888, BC060886, BC140869, BC150294, DB100556
    Consensus CDS
    CCDS10239.1
    UniProtKB/Swiss-Prot
    B2RTY4, Q9UNJ2
    Related
    ENSP00000348349.5, ENST00000356056.10
    Conserved Domains (5) summary
    smart00242
    Location:1431014
    MYSc; Myosin. Large ATPases
    cd00029
    Location:20002048
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04377
    Location:20612246
    RhoGAP_myosin_IX; RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a ...
    cd01385
    Location:1601004
    MYSc_Myo9; class IX myosin, motor domain
    cl00155
    Location:6110
    UBQ; Ubiquitin-like proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    71822291..72118600 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047432576.1XP_047288532.1  unconventional myosin-IXa isoform X14

  2. XM_047432553.1XP_047288509.1  unconventional myosin-IXa isoform X5

  3. XM_047432585.1XP_047288541.1  unconventional myosin-IXa isoform X20

  4. XM_047432571.1XP_047288527.1  unconventional myosin-IXa isoform X12

  5. XM_047432556.1XP_047288512.1  unconventional myosin-IXa isoform X6

  6. XM_047432578.1XP_047288534.1  unconventional myosin-IXa isoform X16

    UniProtKB/Swiss-Prot
    Q9UNJ2
  7. XM_011521615.4XP_011519917.1  unconventional myosin-IXa isoform X1

    See identical proteins and their annotated locations for XP_011519917.1

    Conserved Domains (5) summary
    smart00242
    Location:1431014
    MYSc; Myosin. Large ATPases
    cd00029
    Location:20722120
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04377
    Location:21332318
    RhoGAP_myosin_IX; RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a ...
    cd01385
    Location:1601004
    MYSc_Myo9; class IX myosin, motor domain
    cl00155
    Location:6110
    UBQ; Ubiquitin-like proteins
  8. XM_047432573.1XP_047288529.1  unconventional myosin-IXa isoform X13

  9. XM_047432569.1XP_047288525.1  unconventional myosin-IXa isoform X12

  10. XM_047432580.1XP_047288536.1  unconventional myosin-IXa isoform X17

  11. XM_047432559.1XP_047288515.1  unconventional myosin-IXa isoform X8

  12. XM_047432554.1XP_047288510.1  unconventional myosin-IXa isoform X6

  13. XM_047432551.1XP_047288507.1  unconventional myosin-IXa isoform X5

  14. XM_047432584.1XP_047288540.1  unconventional myosin-IXa isoform X19

  15. XM_047432565.1XP_047288521.1  unconventional myosin-IXa isoform X10

  16. XM_047432561.1XP_047288517.1  unconventional myosin-IXa isoform X9

  17. XM_047432575.1XP_047288531.1  unconventional myosin-IXa isoform X14

  18. XM_047432549.1XP_047288505.1  unconventional myosin-IXa isoform X4

  19. XM_047432547.1XP_047288503.1  unconventional myosin-IXa isoform X2

  20. XM_011521616.4XP_011519918.1  unconventional myosin-IXa isoform X1

    See identical proteins and their annotated locations for XP_011519918.1

    Conserved Domains (5) summary
    smart00242
    Location:1431014
    MYSc; Myosin. Large ATPases
    cd00029
    Location:20722120
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04377
    Location:21332318
    RhoGAP_myosin_IX; RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a ...
    cd01385
    Location:1601004
    MYSc_Myo9; class IX myosin, motor domain
    cl00155
    Location:6110
    UBQ; Ubiquitin-like proteins
  21. XM_047432577.1XP_047288533.1  unconventional myosin-IXa isoform X15

  22. XM_047432572.1XP_047288528.1  unconventional myosin-IXa isoform X13

  23. XM_047432568.1XP_047288524.1  unconventional myosin-IXa isoform X12

  24. XM_047432581.1XP_047288537.1  unconventional myosin-IXa isoform X18

  25. XM_017022230.3XP_016877719.1  unconventional myosin-IXa isoform X17

  26. XM_047432558.1XP_047288514.1  unconventional myosin-IXa isoform X8

  27. XM_011521620.4XP_011519922.1  unconventional myosin-IXa isoform X6

    Conserved Domains (5) summary
    smart00242
    Location:143995
    MYSc; Myosin. Large ATPases
    cd00029
    Location:20522100
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04377
    Location:21132298
    RhoGAP_myosin_IX; RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a ...
    cd01385
    Location:160985
    MYSc_Myo9; class IX myosin, motor domain
    cl00155
    Location:6110
    UBQ; Ubiquitin-like proteins
  28. XM_047432557.1XP_047288513.1  unconventional myosin-IXa isoform X7

  29. XM_011521619.4XP_011519921.1  unconventional myosin-IXa isoform X5

    Conserved Domains (5) summary
    smart00242
    Location:143995
    MYSc; Myosin. Large ATPases
    cd00029
    Location:20532101
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04377
    Location:21142299
    RhoGAP_myosin_IX; RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a ...
    cd01385
    Location:160985
    MYSc_Myo9; class IX myosin, motor domain
    cl00155
    Location:6110
    UBQ; Ubiquitin-like proteins
  30. XM_047432583.1XP_047288539.1  unconventional myosin-IXa isoform X19

  31. XM_047432567.1XP_047288523.1  unconventional myosin-IXa isoform X11

  32. XM_047432564.1XP_047288520.1  unconventional myosin-IXa isoform X10

  33. XM_011521621.4XP_011519923.1  unconventional myosin-IXa isoform X9

    Conserved Domains (5) summary
    smart00242
    Location:143974
    MYSc; Myosin. Large ATPases
    cd00029
    Location:20322080
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04377
    Location:20932278
    RhoGAP_myosin_IX; RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a ...
    cd01385
    Location:160964
    MYSc_Myo9; class IX myosin, motor domain
    cl00155
    Location:6110
    UBQ; Ubiquitin-like proteins
  34. XM_011521622.4XP_011519924.1  unconventional myosin-IXa isoform X14

    Conserved Domains (5) summary
    smart00242
    Location:1431014
    MYSc; Myosin. Large ATPases
    cd00029
    Location:20002048
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04377
    Location:20612246
    RhoGAP_myosin_IX; RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a ...
    cd01385
    Location:1601004
    MYSc_Myo9; class IX myosin, motor domain
    cl00155
    Location:6110
    UBQ; Ubiquitin-like proteins
  35. XM_006720539.4XP_006720602.1  unconventional myosin-IXa isoform X4

    UniProtKB/Swiss-Prot
    B2RTY4
    Conserved Domains (5) summary
    smart00242
    Location:1431014
    MYSc; Myosin. Large ATPases
    cd00029
    Location:20712119
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04377
    Location:21322317
    RhoGAP_myosin_IX; RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a ...
    cd01385
    Location:1601004
    MYSc_Myo9; class IX myosin, motor domain
    cl00155
    Location:6110
    UBQ; Ubiquitin-like proteins
  36. XM_011521617.4XP_011519919.1  unconventional myosin-IXa isoform X2

    Conserved Domains (5) summary
    smart00242
    Location:1431014
    MYSc; Myosin. Large ATPases
    cd00029
    Location:20712119
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04377
    Location:21322317
    RhoGAP_myosin_IX; RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a ...
    cd01385
    Location:1601004
    MYSc_Myo9; class IX myosin, motor domain
    cl00155
    Location:6110
    UBQ; Ubiquitin-like proteins
  37. XM_011521618.4XP_011519920.1  unconventional myosin-IXa isoform X3

    Conserved Domains (5) summary
    smart00242
    Location:1431014
    MYSc; Myosin. Large ATPases
    cd00029
    Location:20722120
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04377
    Location:21332318
    RhoGAP_myosin_IX; RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a ...
    cd01385
    Location:1601004
    MYSc_Myo9; class IX myosin, motor domain
    cl00155
    Location:6110
    UBQ; Ubiquitin-like proteins
  38. XM_011521613.4XP_011519915.1  unconventional myosin-IXa isoform X1

    See identical proteins and their annotated locations for XP_011519915.1

    Conserved Domains (5) summary
    smart00242
    Location:1431014
    MYSc; Myosin. Large ATPases
    cd00029
    Location:20722120
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04377
    Location:21332318
    RhoGAP_myosin_IX; RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a ...
    cd01385
    Location:1601004
    MYSc_Myo9; class IX myosin, motor domain
    cl00155
    Location:6110
    UBQ; Ubiquitin-like proteins
  39. XM_047432570.1XP_047288526.1  unconventional myosin-IXa isoform X12

  40. XM_047432579.1XP_047288535.1  unconventional myosin-IXa isoform X17

  41. XM_047432560.1XP_047288516.1  unconventional myosin-IXa isoform X8

  42. XM_047432555.1XP_047288511.1  unconventional myosin-IXa isoform X6

  43. XM_047432552.1XP_047288508.1  unconventional myosin-IXa isoform X5

  44. XM_047432566.1XP_047288522.1  unconventional myosin-IXa isoform X10

  45. XM_047432562.1XP_047288518.1  unconventional myosin-IXa isoform X9

  46. XM_017022229.2XP_016877718.1  unconventional myosin-IXa isoform X14

    Conserved Domains (5) summary
    smart00242
    Location:1431014
    MYSc; Myosin. Large ATPases
    cd00029
    Location:20002048
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04377
    Location:20612246
    RhoGAP_myosin_IX; RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a ...
    cd01385
    Location:1601004
    MYSc_Myo9; class IX myosin, motor domain
    cl00155
    Location:6110
    UBQ; Ubiquitin-like proteins
  47. XM_047432550.1XP_047288506.1  unconventional myosin-IXa isoform X4

  48. XM_047432548.1XP_047288504.1  unconventional myosin-IXa isoform X2

  49. XM_011521614.4XP_011519916.1  unconventional myosin-IXa isoform X1

    See identical proteins and their annotated locations for XP_011519916.1

    Conserved Domains (5) summary
    smart00242
    Location:1431014
    MYSc; Myosin. Large ATPases
    cd00029
    Location:20722120
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04377
    Location:21332318
    RhoGAP_myosin_IX; RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a ...
    cd01385
    Location:1601004
    MYSc_Myo9; class IX myosin, motor domain
    cl00155
    Location:6110
    UBQ; Ubiquitin-like proteins

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    69641241..69934886 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)