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MYO9A myosin IXA [ Homo sapiens (human) ]

Gene ID: 4649, updated on 3-Jun-2018
Official Symbol
MYO9Aprovided by HGNC
Official Full Name
myosin IXAprovided by HGNC
Primary source
HGNC:HGNC:7608
See related
Ensembl:ENSG00000066933 MIM:604875; Vega:OTTHUMG00000133440
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). Unconventional myosins contain the basic domains of conventional myosins and are further distinguished from class members by their tail domains. They function as actin-based molecular motors. Mutations in this gene have been associated with Bardet-Biedl Syndrome. [provided by RefSeq, Dec 2011]
Expression
Broad expression in testis (RPKM 12.9), thyroid (RPKM 5.9) and 24 other tissues See more
Orthologs
See MYO9A in Genome Data Viewer
Location:
15q23
Exon count:
48
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 15 NC_000015.10 (71822291..72118577, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (72114632..72410440, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene thrombospondin type 1 domain containing 4 Neighboring gene THSD4 antisense RNA 2 Neighboring gene RNA, 5S ribosomal pseudogene 399 Neighboring gene nuclear receptor subfamily 2 group E member 3 Neighboring gene uncharacterized LOC107984713 Neighboring gene uncharacterized LOC107984714 Neighboring gene eukaryotic translation initiation factor 5A2 pseudogene 1 Neighboring gene RNA, U2 small nuclear 65, pseudogene Neighboring gene uncharacterized LOC107984715 Neighboring gene ribosomal protein L21 pseudogene 115 Neighboring gene SUMO peptidase family member, NEDD8 specific Neighboring gene GRAM domain containing 2A

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Congenital myasthenic syndrome Compare labs

NHGRI GWAS Catalog

Description
Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
NHGRI GWA Catalog
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
NHGRI GWA Catalog
  • Rho GTPase cycle, organism-specific biosystem (from REACTOME)
    Rho GTPase cycle, organism-specific biosystemThe cycling of Rho GTPases is tightly controlled by three classes of protein. These are (1) guanine nucleotide dissociation inhibitors or GDIs, which maintain Rho proteins in an inactive state in the...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ11061, FLJ13244, MGC71859

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activator activity TAS
Traceable Author Statement
more info
 
actin binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
microtubule binding IEA
Inferred from Electronic Annotation
more info
 
microtubule motor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell junction assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
establishment of epithelial cell apical/basal polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
microtubule-based movement IEA
Inferred from Electronic Annotation
more info
 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
visual perception TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
unconventional myosin complex NAS
Non-traceable Author Statement
more info
PubMed 
Preferred Names
unconventional myosin-IXa
Names
myosin-IXa
unconventional myosin-9a

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006901.3NP_008832.2  unconventional myosin-IXa

    See identical proteins and their annotated locations for NP_008832.2

    Status: REVIEWED

    Source sequence(s)
    AC020779, AC022872, AF117888, BC060886, BC140869, BC150294, DB100556
    Consensus CDS
    CCDS10239.1
    UniProtKB/Swiss-Prot
    B2RTY4
    Related
    ENSP00000348349.5, OTTHUMP00000164639, ENST00000356056.9, OTTHUMT00000257308
    Conserved Domains (5) summary
    smart00242
    Location:1431014
    MYSc; Myosin. Large ATPases
    cd00029
    Location:20002048
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04377
    Location:20612246
    RhoGAP_myosin_IX; RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a ...
    cd01385
    Location:1601004
    MYSc_Myo9; class IX myosin, motor domain
    cl00155
    Location:6110
    UBQ; Ubiquitin-like proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p12 Primary Assembly

    Range
    71822291..72118577 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521615.3XP_011519917.1  unconventional myosin-IXa isoform X1

    See identical proteins and their annotated locations for XP_011519917.1

    Conserved Domains (5) summary
    smart00242
    Location:1431014
    MYSc; Myosin. Large ATPases
    cd00029
    Location:20722120
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04377
    Location:21332318
    RhoGAP_myosin_IX; RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a ...
    cd01385
    Location:1601004
    MYSc_Myo9; class IX myosin, motor domain
    cl00155
    Location:6110
    UBQ; Ubiquitin-like proteins
  2. XM_011521616.3XP_011519918.1  unconventional myosin-IXa isoform X1

    See identical proteins and their annotated locations for XP_011519918.1

    Conserved Domains (5) summary
    smart00242
    Location:1431014
    MYSc; Myosin. Large ATPases
    cd00029
    Location:20722120
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04377
    Location:21332318
    RhoGAP_myosin_IX; RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a ...
    cd01385
    Location:1601004
    MYSc_Myo9; class IX myosin, motor domain
    cl00155
    Location:6110
    UBQ; Ubiquitin-like proteins
  3. XM_017022230.2XP_016877719.1  unconventional myosin-IXa isoform X9

  4. XM_011521620.3XP_011519922.1  unconventional myosin-IXa isoform X6

    Conserved Domains (5) summary
    smart00242
    Location:143995
    MYSc; Myosin. Large ATPases
    cd00029
    Location:20522100
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04377
    Location:21132298
    RhoGAP_myosin_IX; RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a ...
    cd01385
    Location:160985
    MYSc_Myo9; class IX myosin, motor domain
    cl00155
    Location:6110
    UBQ; Ubiquitin-like proteins
  5. XM_011521619.3XP_011519921.1  unconventional myosin-IXa isoform X5

    Conserved Domains (5) summary
    smart00242
    Location:143995
    MYSc; Myosin. Large ATPases
    cd00029
    Location:20532101
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04377
    Location:21142299
    RhoGAP_myosin_IX; RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a ...
    cd01385
    Location:160985
    MYSc_Myo9; class IX myosin, motor domain
    cl00155
    Location:6110
    UBQ; Ubiquitin-like proteins
  6. XM_011521621.3XP_011519923.1  unconventional myosin-IXa isoform X7

    Conserved Domains (5) summary
    smart00242
    Location:143974
    MYSc; Myosin. Large ATPases
    cd00029
    Location:20322080
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04377
    Location:20932278
    RhoGAP_myosin_IX; RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a ...
    cd01385
    Location:160964
    MYSc_Myo9; class IX myosin, motor domain
    cl00155
    Location:6110
    UBQ; Ubiquitin-like proteins
  7. XM_011521622.3XP_011519924.1  unconventional myosin-IXa isoform X8

    Conserved Domains (5) summary
    smart00242
    Location:1431014
    MYSc; Myosin. Large ATPases
    cd00029
    Location:20002048
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04377
    Location:20612246
    RhoGAP_myosin_IX; RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a ...
    cd01385
    Location:1601004
    MYSc_Myo9; class IX myosin, motor domain
    cl00155
    Location:6110
    UBQ; Ubiquitin-like proteins
  8. XM_006720539.3XP_006720602.1  unconventional myosin-IXa isoform X4

    UniProtKB/Swiss-Prot
    B2RTY4
    Conserved Domains (5) summary
    smart00242
    Location:1431014
    MYSc; Myosin. Large ATPases
    cd00029
    Location:20712119
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04377
    Location:21322317
    RhoGAP_myosin_IX; RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a ...
    cd01385
    Location:1601004
    MYSc_Myo9; class IX myosin, motor domain
    cl00155
    Location:6110
    UBQ; Ubiquitin-like proteins
  9. XM_011521617.3XP_011519919.1  unconventional myosin-IXa isoform X2

    Conserved Domains (5) summary
    smart00242
    Location:1431014
    MYSc; Myosin. Large ATPases
    cd00029
    Location:20712119
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04377
    Location:21322317
    RhoGAP_myosin_IX; RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a ...
    cd01385
    Location:1601004
    MYSc_Myo9; class IX myosin, motor domain
    cl00155
    Location:6110
    UBQ; Ubiquitin-like proteins
  10. XM_011521618.3XP_011519920.1  unconventional myosin-IXa isoform X3

    Conserved Domains (5) summary
    smart00242
    Location:1431014
    MYSc; Myosin. Large ATPases
    cd00029
    Location:20722120
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04377
    Location:21332318
    RhoGAP_myosin_IX; RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a ...
    cd01385
    Location:1601004
    MYSc_Myo9; class IX myosin, motor domain
    cl00155
    Location:6110
    UBQ; Ubiquitin-like proteins
  11. XM_011521613.3XP_011519915.1  unconventional myosin-IXa isoform X1

    See identical proteins and their annotated locations for XP_011519915.1

    Conserved Domains (5) summary
    smart00242
    Location:1431014
    MYSc; Myosin. Large ATPases
    cd00029
    Location:20722120
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04377
    Location:21332318
    RhoGAP_myosin_IX; RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a ...
    cd01385
    Location:1601004
    MYSc_Myo9; class IX myosin, motor domain
    cl00155
    Location:6110
    UBQ; Ubiquitin-like proteins
  12. XM_017022229.1XP_016877718.1  unconventional myosin-IXa isoform X8

    Conserved Domains (5) summary
    smart00242
    Location:1431014
    MYSc; Myosin. Large ATPases
    cd00029
    Location:20002048
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04377
    Location:20612246
    RhoGAP_myosin_IX; RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a ...
    cd01385
    Location:1601004
    MYSc_Myo9; class IX myosin, motor domain
    cl00155
    Location:6110
    UBQ; Ubiquitin-like proteins
  13. XM_011521614.3XP_011519916.1  unconventional myosin-IXa isoform X1

    See identical proteins and their annotated locations for XP_011519916.1

    Conserved Domains (5) summary
    smart00242
    Location:1431014
    MYSc; Myosin. Large ATPases
    cd00029
    Location:20722120
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04377
    Location:21332318
    RhoGAP_myosin_IX; RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a ...
    cd01385
    Location:1601004
    MYSc_Myo9; class IX myosin, motor domain
    cl00155
    Location:6110
    UBQ; Ubiquitin-like proteins
  14. XM_011521623.3XP_011519925.1  unconventional myosin-IXa isoform X10

    Related
    ENSP00000457945.1, OTTHUMP00000249511, ENST00000561618.5
    Conserved Domains (3) summary
    cd00029
    Location:11711219
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04377
    Location:12321417
    RhoGAP_myosin_IX; RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a ...
    cl22853
    Location:1103
    Motor_domain; Myosin and Kinesin motor domain
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