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MYO5B myosin VB [ Homo sapiens (human) ]

Gene ID: 4645, updated on 5-Apr-2020

Summary

Official Symbol
MYO5Bprovided by HGNC
Official Full Name
myosin VBprovided by HGNC
Primary source
HGNC:HGNC:7603
See related
Ensembl:ENSG00000167306 MIM:606540
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene, together with other proteins, may be involved in plasma membrane recycling. Mutations in this gene are associated with microvillous inclusion disease. [provided by RefSeq, Sep 2009]
Expression
Broad expression in small intestine (RPKM 15.1), duodenum (RPKM 14.8) and 18 other tissues See more
Orthologs

Genomic context

See MYO5B in Genome Data Viewer
Location:
18q21.1
Exon count:
40
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (49822789..50195147, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (47349156..47721542, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene acetyl-CoA acyltransferase 2 Neighboring gene small Cajal body-specific RNA 17 Neighboring gene small nucleolar RNA host gene 22 Neighboring gene Sharpr-MPRA regulatory region 7262 Neighboring gene RNA, 5S ribosomal pseudogene 457 Neighboring gene adenosine deaminase domain containing 1 pseudogene 2 Neighboring gene microRNA 4320 Neighboring gene RNA, 7SL, cytoplasmic 310, pseudogene Neighboring gene cilia and flagella associated protein 53

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1119

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
Rab GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin-dependent ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microfilament motor activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endosomal transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein transport IEA
Inferred from Electronic Annotation
more info
 
renal water homeostasis TAS
Traceable Author Statement
more info
 
vesicle transport along actin filament IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
apical cortex IDA
Inferred from Direct Assay
more info
PubMed 
cell IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasmic vesicle membrane TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
myosin complex IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with recycling endosome IC
Inferred by Curator
more info
PubMed 
vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
unconventional myosin-Vb
Names
MYO5B variant protein
myosin-Vb

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012925.2 RefSeqGene

    Range
    4935..377293
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001080467.3NP_001073936.1  unconventional myosin-Vb

    See identical proteins and their annotated locations for NP_001073936.1

    Status: REVIEWED

    Source sequence(s)
    AB290160, AC105224, AK025336, AY274809, BC032511, BX641287, DA350416, Z38208
    Consensus CDS
    CCDS42436.1
    UniProtKB/Swiss-Prot
    Q9ULV0
    UniProtKB/TrEMBL
    Q7Z7A5
    Related
    ENSP00000285039.6, ENST00000285039.12
    Conserved Domains (6) summary
    smart00015
    Location:860881
    IQ; Calmodulin-binding motif
    smart00242
    Location:64760
    MYSc; Myosin. Large ATPases
    cd15477
    Location:14741845
    Myo5b_CBD; Cargo binding domain of myosin 5b
    cd01380
    Location:83749
    MYSc_Myo5; class V myosin, motor domain
    pfam14915
    Location:8951172
    CCDC144C; CCDC144C protein coiled-coil region
    cl23720
    Location:9801080
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    49822789..50195147 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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