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MYO1D myosin ID [ Homo sapiens (human) ]

Gene ID: 4642, updated on 5-Jul-2020

Summary

Official Symbol
MYO1Dprovided by HGNC
Official Full Name
myosin IDprovided by HGNC
Primary source
HGNC:HGNC:7598
See related
Ensembl:ENSG00000176658 MIM:606539
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
myr4; PPP1R108
Expression
Broad expression in colon (RPKM 49.5), small intestine (RPKM 32.7) and 22 other tissues See more
Orthologs

Genomic context

See MYO1D in Genome Data Viewer
Location:
17q11.2
Exon count:
27
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (32492522..32877172, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (30819628..31203902, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene proteasome 26S subunit, non-ATPase 11 Neighboring gene uncharacterized LOC105371734 Neighboring gene uncharacterized LOC107985012 Neighboring gene cyclin dependent kinase 5 regulatory subunit 1 Neighboring gene uncharacterized LOC102724715 Neighboring gene CRISPRi-validated cis-regulatory element chr17.1747 Neighboring gene CRISPRi-validated cis-regulatory element chr17.1750

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetic association of short sleep duration with hypertension incidence--a 6-year follow-up in the Korean genome and epidemiology study.
NHGRI GWA Catalog
Genome-Wide Association Identifies Regulatory Loci Associated with Distinct Local Histogram Emphysema Patterns.
NHGRI GWA Catalog
Genome-wide association study of pancreatic cancer in Japanese population.
NHGRI GWA Catalog
Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0727

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin filament binding ISS
Inferred from Sequence or Structural Similarity
more info
 
actin-dependent ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin-dependent ATPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
calcium-dependent protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
calmodulin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microfilament motor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular localization ISS
Inferred from Sequence or Structural Similarity
more info
 
early endosome to recycling endosome transport ISS
Inferred from Sequence or Structural Similarity
more info
 
forebrain development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein transport IEA
Inferred from Electronic Annotation
more info
 
vesicle transport along actin filament IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
apical dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
axolemma ISS
Inferred from Sequence or Structural Similarity
more info
 
axon ISS
Inferred from Sequence or Structural Similarity
more info
 
basolateral plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
brush border ISS
Inferred from Sequence or Structural Similarity
more info
 
cell cortex IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasmic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
early endosome IEA
Inferred from Electronic Annotation
more info
 
endosome ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular exosome HDA PubMed 
microvillus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
myelin sheath ISS
Inferred from Sequence or Structural Similarity
more info
 
myosin complex ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
 
neuronal cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
perikaryon IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane raft IEA
Inferred from Electronic Annotation
more info
 
smooth endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
unconventional myosin-Id
Names
myosin-I gamma
protein phosphatase 1, regulatory subunit 108

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303279.2NP_001290208.1  unconventional myosin-Id isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 3' terminal exon, resulting in a different 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AB018270, AK127942, BC030602, DB363168
    Consensus CDS
    CCDS76991.1
    UniProtKB/Swiss-Prot
    O94832
    UniProtKB/TrEMBL
    J3QRN6
    Related
    ENSP00000464305.1, ENST00000579584.5
    Conserved Domains (3) summary
    smart00242
    Location:4694
    MYSc; Myosin. Large ATPases
    cd01378
    Location:24682
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:803955
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
  2. NM_001303280.2NP_001290209.1  unconventional myosin-Id isoform 3

    See identical proteins and their annotated locations for NP_001290209.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks multiple 3' coding exons and contains an alternate 3' terminal exon, resulting in a different 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    BC030602
    Consensus CDS
    CCDS76992.1
    UniProtKB/TrEMBL
    J3KRL0
    Related
    ENSP00000462055.1, ENST00000583621.1
    Conserved Domains (1) summary
    cl22853
    Location:24433
    Motor_domain; Myosin and Kinesin motor domain
  3. NM_015194.3NP_056009.1  unconventional myosin-Id isoform 1

    See identical proteins and their annotated locations for NP_056009.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AB018270, AC007982, BC030602, BC030796
    Consensus CDS
    CCDS32615.1
    UniProtKB/Swiss-Prot
    O94832
    UniProtKB/TrEMBL
    Q8N618
    Related
    ENSP00000324527.5, ENST00000318217.10
    Conserved Domains (3) summary
    smart00242
    Location:4694
    MYSc; Myosin. Large ATPases
    cd01378
    Location:24682
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:803997
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    32492522..32877172 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450770.1XP_024306538.1  unconventional myosin-Id isoform X2

    Related
    ENSP00000464741.1, ENST00000394649.8
    Conserved Domains (2) summary
    cd01378
    Location:1594
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:715891
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
  2. XM_017024685.2XP_016880174.1  unconventional myosin-Id isoform X1

RNA

  1. XR_934470.2 RNA Sequence

  2. XR_001752521.2 RNA Sequence

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