Format

Send to:

Choose Destination

MYO1C myosin IC [ Homo sapiens (human) ]

Gene ID: 4641, updated on 5-Sep-2021

Summary

Official Symbol
MYO1Cprovided by HGNC
Official Full Name
myosin ICprovided by HGNC
Primary source
HGNC:HGNC:7597
See related
Ensembl:ENSG00000197879 MIM:606538
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NMI; MMIb; myr2; MMI-beta
Summary
This gene encodes a member of the unconventional myosin protein family, which are actin-based molecular motors. The protein is found in the cytoplasm, and one isoform with a unique N-terminus is also found in the nucleus. The nuclear isoform associates with RNA polymerase I and II and functions in transcription initiation. The mouse ortholog of this protein also functions in intracellular vesicle transport to the plasma membrane. Multiple transcript variants encoding different isoforms have been found for this gene. The related gene myosin IE has been referred to as myosin IC in the literature, but it is a distinct locus on chromosome 19. [provided by RefSeq, Jul 2008]
Annotation information
Note: MYO1C (Gene ID: 4641) and MYO1E (Gene ID: 4643) share the MYO1C symbol/alias in common. MYO1C is a widely used alternative name for myosin IE (MYO1E), which can be confused with the official symbol for myosin IC (MYO1C). [06 Feb 2019]
Expression
Ubiquitous expression in fat (RPKM 109.9), lung (RPKM 53.1) and 23 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See MYO1C in Genome Data Viewer
Location:
17p13.3
Exon count:
37
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (1464186..1492686, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (1367480..1395980, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon Neighboring gene Sharpr-MPRA regulatory region 4720 Neighboring gene CRK proto-oncogene, adaptor protein Neighboring gene uncharacterized LOC105371483 Neighboring gene inositol polyphosphate-5-phosphatase K Neighboring gene PITPNA antisense RNA 1 Neighboring gene phosphatidylinositol transfer protein alpha

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23903

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein C-terminus binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in basal plasma membrane IDA
Inferred from Direct Assay
more info
 
located_in brush border IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
part_of filamentous actin IDA
Inferred from Direct Assay
more info
 
located_in lateral plasma membrane IDA
Inferred from Direct Assay
more info
 
located_in membrane HDA PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in microvillus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in microvillus IDA
Inferred from Direct Assay
more info
 
located_in nuclear body IDA
Inferred from Direct Assay
more info
 
part_of nuclear pore IEA
Inferred from Electronic Annotation
more info
 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in phagocytic vesicle IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in ruffle membrane IEA
Inferred from Electronic Annotation
more info
 
located_in stereocilium membrane IEA
Inferred from Electronic Annotation
more info
 
NOT located_in stress fiber IDA
Inferred from Direct Assay
more info
 
part_of unconventional myosin complex TAS
Traceable Author Statement
more info
PubMed 
is_active_in vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
unconventional myosin-Ic
Names
myosin-I beta
myosin-Ic
nuclear myosin I

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047063.1 RefSeqGene

    Range
    5022..33522
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001080779.2NP_001074248.1  unconventional myosin-Ic isoform a

    See identical proteins and their annotated locations for NP_001074248.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AI220881, BC068013, CA422782, DB241937
    Consensus CDS
    CCDS42226.1
    UniProtKB/Swiss-Prot
    O00159
    Related
    ENSP00000496954.1, ENST00000648651.1
    Conserved Domains (4) summary
    smart00015
    Location:756776
    IQ; Calmodulin-binding motif
    smart00242
    Location:43731
    MYSc; Myosin. Large ATPases
    cd01378
    Location:62718
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:8741041
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
  2. NM_001080950.2NP_001074419.1  unconventional myosin-Ic isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' CDS, compared to variant 1. The resulting isoform (b) has a shorter and unique N-terminus when compared to isoform a. This isoform is also known as nuclear myosin I.
    Source sequence(s)
    AC100748, AI220881, BC068013, BP284965, CA422782, CN313279, DB241937
    Consensus CDS
    CCDS45562.1
    UniProtKB/Swiss-Prot
    O00159
    Related
    ENSP00000496799.1, ENST00000648446.1
    Conserved Domains (4) summary
    smart00015
    Location:737757
    IQ; Calmodulin-binding motif
    smart00242
    Location:24712
    MYSc; Myosin. Large ATPases
    cd01378
    Location:43699
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:8551022
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
  3. NM_001363855.1NP_001350784.1  unconventional myosin-Ic isoform d

    Status: REVIEWED

    Source sequence(s)
    AC100748, AK295761, KF495829
    Consensus CDS
    CCDS86556.1
    Related
    ENSP00000437685.2, ENST00000545534.6
    Conserved Domains (3) summary
    smart00015
    Location:732752
    IQ; Calmodulin-binding motif
    cd01378
    Location:38694
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:8501016
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
  4. NM_033375.5NP_203693.3  unconventional myosin-Ic isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (c) has a shorter N terminus when compared to isoform a.
    Source sequence(s)
    AC100748, AI220881, BC068013, BP255642, CA422782, DB241937
    Consensus CDS
    CCDS11003.1
    UniProtKB/Swiss-Prot
    O00159
    Related
    ENSP00000354283.2, ENST00000361007.7
    Conserved Domains (3) summary
    smart00015
    Location:721741
    IQ; Calmodulin-binding motif
    cd01378
    Location:27683
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:8391005
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    1464186..1492686 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450768.1XP_024306536.1  unconventional myosin-Ic isoform X2

    Related
    ENSP00000493973.1, ENST00000646049.1
    Conserved Domains (3) summary
    smart00015
    Location:721741
    IQ; Calmodulin-binding motif
    cd01378
    Location:27683
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:8391005
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
  2. XM_024450769.1XP_024306537.1  unconventional myosin-Ic isoform X2

    Related
    ENSP00000459174.1, ENST00000575158.5
    Conserved Domains (3) summary
    smart00015
    Location:721741
    IQ; Calmodulin-binding motif
    cd01378
    Location:27683
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:8391005
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
Support Center