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MYO1C myosin IC [ Homo sapiens (human) ]

Gene ID: 4641, updated on 3-Mar-2019

Summary

Official Symbol
MYO1Cprovided by HGNC
Official Full Name
myosin ICprovided by HGNC
Primary source
HGNC:HGNC:7597
See related
Ensembl:ENSG00000197879 MIM:606538
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NMI; MMIb; myr2; MMI-beta
Summary
This gene encodes a member of the unconventional myosin protein family, which are actin-based molecular motors. The protein is found in the cytoplasm, and one isoform with a unique N-terminus is also found in the nucleus. The nuclear isoform associates with RNA polymerase I and II and functions in transcription initiation. The mouse ortholog of this protein also functions in intracellular vesicle transport to the plasma membrane. Multiple transcript variants encoding different isoforms have been found for this gene. The related gene myosin IE has been referred to as myosin IC in the literature, but it is a distinct locus on chromosome 19. [provided by RefSeq, Jul 2008]
Annotation information
Note: MYO1C (Gene ID: 4641) and MYO1E (Gene ID: 4643) share the MYO1C symbol/alias in common. MYO1C is a widely used alternative name for myosin IE (MYO1E), which can be confused with the official symbol for myosin IC (MYO1C). [06 Feb 2019]
Expression
Ubiquitous expression in fat (RPKM 109.9), lung (RPKM 53.1) and 23 other tissues See more
Orthologs

Genomic context

See MYO1C in Genome Data Viewer
Location:
17p13.3
Exon count:
37
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (1464186..1492707, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (1367480..1396001, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon Neighboring gene CRK proto-oncogene, adaptor protein Neighboring gene uncharacterized LOC105371483 Neighboring gene inositol polyphosphate-5-phosphatase K Neighboring gene PITPNA antisense RNA 1 Neighboring gene phosphatidylinositol transfer protein alpha

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • B-WICH complex positively regulates rRNA expression, organism-specific biosystem (from REACTOME)
    B-WICH complex positively regulates rRNA expression, organism-specific biosystemThe B-WICH complex is a large 3 Mdalton complex containing SMARCA5 (SNF2H), BAZ1B (WSTF), ERCC6 (CSB), MYO1C (Nuclear myosin 1c) (Cavellan et al. 2006, Percipalle et al. 2006, Vintermist et al. 2001,...
  • Epigenetic regulation of gene expression, organism-specific biosystem (from REACTOME)
    Epigenetic regulation of gene expression, organism-specific biosystemEpigenetic processes regulate gene expression by modulating the frequency, rate, or extent of gene expression in a mitotically or meiotically heritable way that does not entail a change in the DNA se...
  • Fcgamma receptor (FCGR) dependent phagocytosis, organism-specific biosystem (from REACTOME)
    Fcgamma receptor (FCGR) dependent phagocytosis, organism-specific biosystemPhagocytosis is one of the important innate immune responses that function to eliminate invading infectious agents. Monocytes, macrophages, and neutrophils are the professional phagocytic cells. Phag...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Insulin Signaling, organism-specific biosystem (from WikiPathways)
    Insulin Signaling, organism-specific biosystemInsulin signaling influences energy metabolism as well as growth. The presence of insulin signals the fed state, and this signal is passed via the AKT branch, which leads to the uptake of glucose fro...
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • Positive epigenetic regulation of rRNA expression, organism-specific biosystem (from REACTOME)
    Positive epigenetic regulation of rRNA expression, organism-specific biosystemTranscription of rRNA genes is controlled by epigenetic activation and repression (reviewed in Percipalle and Farrants 2006, McStay and Grummt 2008, Goodfellow and Zomerdijk 2012, Grummt and Langst 2...
  • Regulation of actin dynamics for phagocytic cup formation, organism-specific biosystem (from REACTOME)
    Regulation of actin dynamics for phagocytic cup formation, organism-specific biosystemThe actin cytoskeleton is fundamental for phagocytosis and members of the Rho family GTPases RAC and CDC42 are involved in actin cytoskeletal regulation leading to pseudopod extension. Active RAC and...
  • Translocation of GLUT4 to the plasma membrane, organism-specific biosystem (from REACTOME)
    Translocation of GLUT4 to the plasma membrane, organism-specific biosystemIn adipocytes and myocytes insulin signaling causes intracellular vesicles carrying the GLUT4 (SLC2A4) glucose transporter to translocate to the plasma membrane, allowing the cells to take up glucose...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23903

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
Ral GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
actin filament binding IEA
Inferred from Electronic Annotation
more info
 
actin-dependent ATPase activity IEA
Inferred from Electronic Annotation
more info
 
calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
microfilament motor activity IEA
Inferred from Electronic Annotation
more info
 
protein C-terminus binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
basal plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
brush border IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
filamentous actin IDA
Inferred from Direct Assay
more info
PubMed 
lateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
microvillus IDA
Inferred from Direct Assay
more info
PubMed 
nuclear body IDA
Inferred from Direct Assay
more info
 
nuclear pore IEA
Inferred from Electronic Annotation
more info
 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
phagocytic vesicle IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
ruffle membrane IEA
Inferred from Electronic Annotation
more info
 
stereocilium membrane IEA
Inferred from Electronic Annotation
more info
 
NOT stress fiber IDA
Inferred from Direct Assay
more info
PubMed 
unconventional myosin complex TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
unconventional myosin-Ic
Names
myosin-I beta
myosin-Ic
nuclear myosin I

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047063.1 RefSeqGene

    Range
    5001..33522
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001080779.2NP_001074248.1  unconventional myosin-Ic isoform a

    See identical proteins and their annotated locations for NP_001074248.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AI220881, BC068013, CA422782, DB241937
    Consensus CDS
    CCDS42226.1
    UniProtKB/Swiss-Prot
    O00159
    Related
    ENSP00000496954.1, ENST00000648651.1
    Conserved Domains (4) summary
    smart00015
    Location:756776
    IQ; Calmodulin-binding motif
    smart00242
    Location:43731
    MYSc; Myosin. Large ATPases
    cd01378
    Location:62718
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:8741041
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
  2. NM_001080950.1NP_001074419.1  unconventional myosin-Ic isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' CDS, compared to variant 1. The resulting isoform (b) has a shorter and unique N-terminus when compared to isoform a. This isoform is also known as nuclear myosin I.
    Source sequence(s)
    AI220881, BC068013, BP284965, CA422782, CN313279, DB241937
    Consensus CDS
    CCDS45562.1
    UniProtKB/Swiss-Prot
    O00159
    Related
    ENSP00000496799.1, ENST00000648446.1
    Conserved Domains (4) summary
    smart00015
    Location:737757
    IQ; Calmodulin-binding motif
    smart00242
    Location:24712
    MYSc; Myosin. Large ATPases
    cd01378
    Location:43699
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:8551022
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
  3. NM_001363855.1NP_001350784.1  unconventional myosin-Ic isoform d

    Status: REVIEWED

    Source sequence(s)
    AC100748, AK295761, KF495829
    Consensus CDS
    CCDS86556.1
    Conserved Domains (3) summary
    smart00015
    Location:732752
    IQ; Calmodulin-binding motif
    cd01378
    Location:38694
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:8501016
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
  4. NM_033375.4NP_203693.3  unconventional myosin-Ic isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (c) has a shorter N terminus when compared to isoform a.
    Source sequence(s)
    AI220881, BC068013, BP255642, CA422782, DB241937
    Consensus CDS
    CCDS11003.1
    UniProtKB/Swiss-Prot
    O00159
    Related
    ENSP00000354283.2, ENST00000361007.7
    Conserved Domains (3) summary
    smart00015
    Location:721741
    IQ; Calmodulin-binding motif
    cd01378
    Location:27683
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:8391005
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    1464186..1492707 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450768.1XP_024306536.1  unconventional myosin-Ic isoform X2

    Conserved Domains (3) summary
    smart00015
    Location:721741
    IQ; Calmodulin-binding motif
    cd01378
    Location:27683
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:8391005
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
  2. XM_024450769.1XP_024306537.1  unconventional myosin-Ic isoform X2

    Related
    ENSP00000459174.1, ENST00000575158.5
    Conserved Domains (3) summary
    smart00015
    Location:721741
    IQ; Calmodulin-binding motif
    cd01378
    Location:27683
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:8391005
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
  3. XM_024450767.1XP_024306535.1  unconventional myosin-Ic isoform X1

    Related
    ENSP00000437685.2, ENST00000545534.6
    Conserved Domains (3) summary
    smart00015
    Location:732752
    IQ; Calmodulin-binding motif
    cd01378
    Location:38694
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:8501016
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
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