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MYL5 myosin light chain 5 [ Homo sapiens (human) ]

Gene ID: 4636, updated on 26-Nov-2021

Summary

Official Symbol
MYL5provided by HGNC
Official Full Name
myosin light chain 5provided by HGNC
Primary source
HGNC:HGNC:7586
See related
Ensembl:ENSG00000215375 MIM:160782
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MYLC2
Summary
This gene encodes one of the myosin light chains, a component of the hexameric ATPase cellular motor protein myosin. Myosin is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene product, one of the regulatory light chains, is expressed in fetal muscle and in adult retina, cerebellum, and basal ganglia. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in fat (RPKM 6.7), duodenum (RPKM 6.7) and 25 other tissues See more
Orthologs
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Genomic context

See MYL5 in Genome Data Viewer
Location:
4p16.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (674542..682028)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (668331..675817)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 6B Neighboring gene PDE6B antisense RNA 1 Neighboring gene ATP synthase membrane subunit e Neighboring gene solute carrier family 49 member 3 Neighboring gene uncharacterized LOC107986245 Neighboring gene polycomb group ring finger 3 Neighboring gene uncharacterized LOC107986246

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Treatment of human brain endothelial cells with Tat markedly elevates GTP-RhoA levels and the potential downstream effectors, such as myosin phosphatase target subunit 1 and myosin light chain PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables structural constituent of muscle TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of muscle contraction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of muscle myosin complex TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
myosin light chain 5
Names
myosin regulatory light chain 5
myosin, light chain 5, regulatory
myosin, light polypeptide 5, regulatory
superfast myosin regulatory light chain 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363650.2NP_001350579.1  myosin light chain 5 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC107464
    Consensus CDS
    CCDS87196.1
    Related
    ENSP00000425162.1, ENST00000511290.5
    Conserved Domains (1) summary
    COG5126
    Location:1118
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
  2. NM_001395441.1NP_001382370.1  myosin light chain 5

    Status: REVIEWED

    Source sequence(s)
    AC107464
    Conserved Domains (1) summary
    COG5126
    Location:15159
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
  3. NM_001395442.1NP_001382371.1  myosin light chain 5

    Status: REVIEWED

    Source sequence(s)
    AC107464
    Conserved Domains (1) summary
    COG5126
    Location:15159
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
  4. NM_001395443.1NP_001382372.1  myosin light chain 5

    Status: REVIEWED

    Source sequence(s)
    AC107464
    Conserved Domains (1) summary
    COG5126
    Location:15159
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
  5. NM_001395444.1NP_001382373.1  myosin light chain 5

    Status: REVIEWED

    Source sequence(s)
    AC107464
    Conserved Domains (1) summary
    COG5126
    Location:1118
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
  6. NM_001395445.1NP_001382374.1  myosin light chain 5

    Status: REVIEWED

    Source sequence(s)
    AC107464
    Conserved Domains (1) summary
    COG5126
    Location:1118
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
  7. NM_001395446.1NP_001382375.1  myosin light chain 5

    Status: REVIEWED

    Source sequence(s)
    AC107464
    Conserved Domains (1) summary
    COG5126
    Location:1118
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
  8. NM_001395447.1NP_001382376.1  myosin light chain 5

    Status: REVIEWED

    Source sequence(s)
    AC107464
    Conserved Domains (1) summary
    COG5126
    Location:1118
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
  9. NM_001395448.1NP_001382377.1  myosin light chain 5

    Status: REVIEWED

    Source sequence(s)
    AC107464
    Conserved Domains (1) summary
    COG5126
    Location:1118
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
  10. NM_001395449.1NP_001382378.1  myosin light chain 5

    Status: REVIEWED

    Source sequence(s)
    AC107464
    Conserved Domains (1) summary
    COG5126
    Location:1118
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
  11. NM_002477.2NP_002468.1  myosin light chain 5 isoform 1

    See identical proteins and their annotated locations for NP_002468.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC107464
    Consensus CDS
    CCDS43197.1
    UniProtKB/Swiss-Prot
    Q02045
    Related
    ENSP00000383023.2, ENST00000400159.6
    Conserved Domains (1) summary
    COG5126
    Location:15159
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    674542..682028
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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