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EGFR epidermal growth factor receptor [ Pan troglodytes (chimpanzee) ]

Gene ID: 463415, updated on 10-Oct-2024

Summary

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Official Symbol
EGFRprovided by VGNC
Official Full Name
epidermal growth factor receptorprovided by VGNC
Primary source
VGNC:VGNC:4334
Locus tag
CK820_G0044415
See related
Ensembl:ENSPTRG00000019196
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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See EGFR in Genome Data Viewer
Location:
chromosome: 6
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 6 NC_072404.2 (60796026..60989002)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 7 NC_072405.1 (58433460..58626457)

Chromosome 6 - NC_072404.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100615113 Neighboring gene SEC61 translocon subunit gamma Neighboring gene rho GTPase-activating protein 5-like Neighboring gene uncharacterized LOC104007224 Neighboring gene uncharacterized LOC129144559 Neighboring gene calmodulin-1-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables epidermal growth factor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables epidermal growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neurogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in basal plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
epidermal growth factor receptor
Names
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
XP_001156264.1
XP_054543526.1
XP_519102.3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072404.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    60796026..60989002
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_519102.9 → XP_519102.3  epidermal growth factor receptor isoform X1

    See identical proteins and their annotated locations for XP_519102.3

    UniProtKB/TrEMBL
    A0A2I3RYF9, A0A2I3T5Z5, A0A2J8JU32, A0A6D2XY58
    Related
    ENSPTRP00000069741.1
    Conserved Domains (5) summary
    cd12093
    Location:634 → 677
    TM_ErbB1; Transmembrane domain of Epidermal Growth Factor Receptor or ErbB1, a Protein Tyrosine Kinase
    cd05108
    Location:704 → 1016
    PTKc_EGFR; Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor
    pfam00757
    Location:185 → 335
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:57 → 168
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:505 → 637
    GF_recep_IV; Growth factor receptor domain IV

  2. XM_001156264.8 → XP_001156264.1  epidermal growth factor receptor isoform X3

    UniProtKB/TrEMBL
    A0A2I3T899, A0A2I3TRV3, A0A2J8JU37, A0A2J8JU42, A0A6D2VT46, A0A6D2W718
    Related
    ENSPTRP00000085471.1
    Conserved Domains (3) summary
    pfam00757
    Location:185 → 335
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:57 → 168
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:505 → 627
    GF_recep_IV; Growth factor receptor domain IV

  3. XM_054687551.2 → XP_054543526.1  epidermal growth factor receptor isoform X2

Nucleotide Protein
Heading Accession and Version

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