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ND-SGDH NADH dehydrogenase (ubiquinone) SGDH subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 46260, updated on 15-May-2025
Official Symbol
ND-SGDHprovided by FlyBase
Official Full Name
NADH dehydrogenase (ubiquinone) SGDH subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0011455
Locus tag
Dmel_CG9762
See related
AllianceGenome:FB:FBgn0011455
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9762; Dmel\CG9762; dND-SGDH; dNDUFB5; l(3)neo18; NDUFB5; NISM; Q9VTU2
Summary
Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone. Located in mitochondrion. Part of respiratory chain complex I. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut primordium; gut section; and larval somatic muscle cell. Orthologous to human NDUFB5 (NADH:ubiquinone oxidoreductase subunit B5). [provided by Alliance of Genome Resources, May 2025]
Orthologs
all
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See ND-SGDH in Genome Data Viewer
Location:
68F5-68F5; 3-38 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12137496..12138584, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12130596..12131684, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45892 Neighboring gene differentially expressed in FDCP 8 homolog Neighboring gene uncharacterized protein Neighboring gene Autophagy-related 12 Neighboring gene Rho GTPase activating protein at 68F Neighboring gene eukaryotic translation initiation factor 3 subunit l

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Extension of Drosophila life span by RNAi of the mitochondrial respiratory chain. Copeland JM, et al. Curr Biol, 2009 Oct 13. PMID 19747824
  2. Complex-I-ty in aging. Hur JH, et al. J Bioenerg Biomembr, 2014 Aug. PMID 24961226, Free PMC Article
  3. 4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila. Zid BM, et al. Cell, 2009 Oct 2. PMID 19804760, Free PMC Article
  4. Mutations in Complex I of the Mitochondrial Electron-Transport Chain Sensitize the Fruit Fly (Drosophila melanogaster) to Ether and Non-Ether Volatile Anesthetics. Borchardt LA, et al. Int J Mol Sci, 2023 Jan 17. PMID 36768163, Free PMC Article
  5. Systemic Regulation of Host Energy and Oogenesis by Microbiome-Derived Mitochondrial Coenzymes. Gnainsky Y, et al. Cell Rep, 2021 Jan 5. PMID 33406416

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in mitochondrial electron transport, NADH to ubiquinone IC
Inferred by Curator
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IC
Inferred by Curator
more info
 PubMed 
located_in mitochondrion HDA PubMed 
part_of respiratory chain complex I IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of respiratory chain complex I IDA
Inferred from Direct Assay
more info
 PubMed 
part_of respiratory chain complex I ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of respiratory chain complex I NAS
Non-traceable Author Statement
more info
 PubMed 
Preferred Names
NADH dehydrogenase (ubiquinone) SGDH subunit
Names
CG9762-PA
CG9762-PB
NADH ubiquinone oxidoreductase SGDH
NADH-ubiquinone oxidoreductase SGDH subunit
NADH:ubiquinone oxidoreductase SGDH subunit
ND-SGDH-PA
ND-SGDH-PB
lethal (3) neo18

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    12137496..12138584 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143785.3 → NP_652042.1  NADH dehydrogenase (ubiquinone) SGDH subunit, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_652042.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VTU2
    Related
    FBpp0075755
    Conserved Domains (1) summary
    pfam09781
    Location:1 → 179
    NDUF_B5; NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit

  2. NM_001274813.1 → NP_001261742.1  NADH dehydrogenase (ubiquinone) SGDH subunit, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261742.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VTU2
    Conserved Domains (1) summary
    pfam09781
    Location:1 → 179
    NDUF_B5; NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VTU2 Q9VTU2

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