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MYH4 myosin heavy chain 4 [ Homo sapiens (human) ]

Gene ID: 4622, updated on 4-Jul-2021

Summary

Official Symbol
MYH4provided by HGNC
Official Full Name
myosin heavy chain 4provided by HGNC
Primary source
HGNC:HGNC:7574
See related
Ensembl:ENSG00000264424 MIM:160742
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MYH2B; MyHC-2B; MyHC-IIb
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See MYH4 in Genome Data Viewer
Location:
17p13.1
Exon count:
40
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (10443058..10469559, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (10346607..10372876, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985004 Neighboring gene myosin heavy chain 13 Neighboring gene myosin heavy chain gene cluster antisense RNA Neighboring gene myosin heavy chain 8 Neighboring gene myosin heavy chain 1 Neighboring gene myosin heavy chain 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity NAS
Non-traceable Author Statement
more info
PubMed 
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables double-stranded RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables microfilament motor activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in ATP metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
involved_in actin filament-based movement NAS
Non-traceable Author Statement
more info
PubMed 
involved_in muscle contraction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in muscle filament sliding NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of muscle myosin complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in myofibril IDA
Inferred from Direct Assay
more info
PubMed 
located_in myosin filament IEA
Inferred from Electronic Annotation
more info
 
located_in sarcomere NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
myosin-4
Names
myosin heavy chain 2b
myosin heavy chain IIb
myosin heavy chain, skeletal muscle, fetal
myosin, heavy chain 4, skeletal muscle
myosin, heavy polypeptide 4, skeletal muscle

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052846.1 RefSeqGene

    Range
    5001..31270
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_017533.2NP_060003.2  myosin-4

    See identical proteins and their annotated locations for NP_060003.2

    Status: VALIDATED

    Source sequence(s)
    AC005323, AF111783
    Consensus CDS
    CCDS11154.1
    UniProtKB/Swiss-Prot
    Q9Y623
    Related
    ENSP00000255381.2, ENST00000255381.2
    Conserved Domains (8) summary
    cd14915
    Location:100770
    MYSc_Myh4; class II myosin heavy chain 4, motor domain
    pfam00063
    Location:88770
    Myosin_head; Myosin head (motor domain)
    pfam01576
    Location:8501927
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:3673
    Myosin_N; Myosin N-terminal SH3-like domain
    cl00459
    Location:12991411
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
    cl19219
    Location:16701767
    DUF342; Protein of unknown function (DUF342)
    cl19764
    Location:13761511
    COG6; Conserved oligomeric complex COG6
    cl23720
    Location:9651098
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    10443058..10469559 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024676.1XP_016880165.1  myosin-4 isoform X1

    UniProtKB/Swiss-Prot
    Q9Y623
    Conserved Domains (8) summary
    cd14915
    Location:100770
    MYSc_Myh4; class II myosin heavy chain 4, motor domain
    pfam00063
    Location:88770
    Myosin_head; Myosin head (motor domain)
    pfam01576
    Location:8501927
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:3673
    Myosin_N; Myosin N-terminal SH3-like domain
    cl00459
    Location:12991411
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
    cl19219
    Location:16701767
    DUF342; Protein of unknown function (DUF342)
    cl19764
    Location:13761511
    COG6; Conserved oligomeric complex COG6
    cl23720
    Location:9651098
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
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