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MYH1 myosin heavy chain 1 [ Homo sapiens (human) ]

Gene ID: 4619, updated on 7-Dec-2018

Summary

Official Symbol
MYH1provided by HGNC
Official Full Name
myosin heavy chain 1provided by HGNC
Primary source
HGNC:HGNC:7567
See related
Ensembl:ENSG00000109061 MIM:160730
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MYHa; HEL71; MYHSA1; MyHC-2x; MyHC-2X/D
Summary
Myosin is a major contractile protein which converts chemical energy into mechanical energy through the hydrolysis of ATP. Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. Myosin heavy chains are encoded by a multigene family. In mammals at least 10 different myosin heavy chain (MYH) isoforms have been described from striated, smooth, and nonmuscle cells. These isoforms show expression that is spatially and temporally regulated during development. [provided by RefSeq, Jul 2008]
Expression
Biased expression in prostate (RPKM 4.3), esophagus (RPKM 3.5) and 2 other tissues See more
Orthologs

Genomic context

See MYH1 in Genome Data Viewer
Location:
17p13.1
Exon count:
40
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (10492307..10518719, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (10395624..10421859, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene myosin heavy chain gene cluster antisense RNA Neighboring gene myosin heavy chain 8 Neighboring gene myosin heavy chain 4 Neighboring gene myosin heavy chain 2 Neighboring gene myosin heavy chain 3 Neighboring gene SCO1, cytochrome c oxidase assembly protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • Tight junction, organism-specific biosystem (from KEGG)
    Tight junction, organism-specific biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
  • Tight junction, conserved biosystem (from KEGG)
    Tight junction, conserved biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
  • Translocation of GLUT4 to the plasma membrane, organism-specific biosystem (from REACTOME)
    Translocation of GLUT4 to the plasma membrane, organism-specific biosystemIn adipocytes and myocytes insulin signaling causes intracellular vesicles carrying the GLUT4 (SLC2A4) glucose transporter to translocate to the plasma membrane, allowing the cells to take up glucose...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC133384

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
actin filament binding IEA
Inferred from Electronic Annotation
more info
 
calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
motor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
muscle contraction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
A band IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
PubMed 
intercalated disc IEA
Inferred from Electronic Annotation
more info
 
muscle myosin complex IDA
Inferred from Direct Assay
more info
PubMed 
myosin filament IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
myosin-1
Names
epididymis luminal protein 71
myHC-IIx/d
myosin heavy chain 2x
myosin heavy chain IIx/d
myosin heavy chain, skeletal muscle, adult 1
myosin, heavy chain 1, skeletal muscle, adult
myosin, heavy polypeptide 1, skeletal muscle, adult

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005963.4NP_005954.3  myosin-1

    See identical proteins and their annotated locations for NP_005954.3

    Status: REVIEWED

    Source sequence(s)
    AF111785, AJ573764, BC114545, DA826478
    Consensus CDS
    CCDS11155.1
    UniProtKB/Swiss-Prot
    P12882
    Related
    ENSP00000226207.5, ENST00000226207.5
    Conserved Domains (8) summary
    cd14910
    Location:100770
    MYSc_Myh1_mammals; class II myosin heavy chain 1, motor domain
    pfam00063
    Location:88770
    Myosin_head; Myosin head (motor domain)
    pfam01576
    Location:8501927
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:3673
    Myosin_N; Myosin N-terminal SH3-like domain
    pfam07851
    Location:17441853
    TMPIT; TMPIT-like protein
    cl00459
    Location:12991411
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
    cl19219
    Location:16701767
    DUF342; Protein of unknown function (DUF342)
    cl23720
    Location:9651098
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    10492307..10518719 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024675.1XP_016880164.1  myosin-1 isoform X1

    UniProtKB/Swiss-Prot
    P12882
    Conserved Domains (8) summary
    cd14910
    Location:100770
    MYSc_Myh1_mammals; class II myosin heavy chain 1, motor domain
    pfam00063
    Location:88770
    Myosin_head; Myosin head (motor domain)
    pfam01576
    Location:8501927
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:3673
    Myosin_N; Myosin N-terminal SH3-like domain
    pfam07851
    Location:17441853
    TMPIT; TMPIT-like protein
    cl00459
    Location:12991411
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
    cl19219
    Location:16701767
    DUF342; Protein of unknown function (DUF342)
    cl23720
    Location:9651098
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
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