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Acsl Acyl-CoA synthetase long-chain [ Drosophila melanogaster (fruit fly) ]

Gene ID: 46068, updated on 18-Sep-2024

Summary

Official Symbol
Acslprovided by FlyBase
Official Full Name
Acyl-CoA synthetase long-chainprovided by FlyBase
Primary source
FLYBASE:FBgn0263120
Locus tag
Dmel_CG8732
See related
AllianceGenome:FB:FBgn0263120
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
7447; ACS; acsl; ACSL1; ACSL3; ACSL3/4; anon-WO0172774.173; CG8732; dAcsl; dFAC; Dmel\CG8732; FACS; FCS; l(2)05847; l(2)44DEa; l(2)7447; l(2)k05304; l(2)SH0465; l(2)SH2 0465
Summary
Enables palmitoyl-CoA ligase activity. Involved in several processes, including axon guidance; organophosphate biosynthetic process; and positive regulation of sequestering of triglyceride. Located in axon; endoplasmic reticulum; and peroxisome. Is expressed in several structures, including adult head; adult heart; and fat body. Used to study non-syndromic X-linked intellectual disability and non-syndromic X-linked intellectual disability 63. Human ortholog(s) of this gene implicated in asthma; breast cancer; intellectual disability; non-syndromic X-linked intellectual disability 63; and prostate cancer. Orthologous to human ACSL3 (acyl-CoA synthetase long chain family member 3) and ACSL4 (acyl-CoA synthetase long chain family member 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See Acsl in Genome Data Viewer
Location:
44E1-44E2; 2-59 cM
Exon count:
17
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8665813..8683022)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4553318..4570527)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44281 Neighboring gene patched Neighboring gene transfer RNA:Leucine-CAG 1-1 Neighboring gene Ubiquinol-cytochrome c reductase 11 kDa subunit-like Neighboring gene uncharacterized protein Neighboring gene Jonah 44E Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables long-chain fatty acid-CoA ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables palmitoyl-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables palmitoyl-CoA ligase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in fatty acid biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
involved_in long-chain fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in long-chain fatty acid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in long-chain fatty-acyl-CoA biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in long-chain fatty-acyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phosphatidylglycerol biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of sequestering of triglyceride IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in segmentation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in peroxisome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
Acyl-CoA synthetase long-chain
Names
Acsl-PA
Acsl-PB
Acsl-PC
Acsl-PD
Acsl-PE
Acsl-PF
Acsl-PG
Acsl-PH
Acsl-PI
Acsl-PJ
Acyl-CoAsynthetase long-chain
CG8732-PA
CG8732-PB
CG8732-PC
CG8732-PD
CG8732-PE
CG8732-PF
CG8732-PG
CG8732-PH
CG8732-PI
CG8732-PJ
Long-chain acyl-CoA synthetase
fatty acyl CoA synthetase
fatty acyl coenzyme A (CoA) synthetase
fatty acyl-CoA synthetase
lethal (2) 44DEa
lethal (2) SH0465
NP_001014507.1
NP_001014508.1
NP_001014509.1
NP_001014510.1
NP_001014511.1
NP_001014512.1
NP_001260810.1
NP_652034.2
NP_724695.1
NP_724696.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    8665813..8683022
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001014511.2NP_001014511.1  Acyl-CoA synthetase long-chain, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014511.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86NS4, Q8T3L1, Q9V4W4
    Conserved Domains (2) summary
    cd05927
    Location:129713
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    PLN02387
    Location:82714
    PLN02387; long-chain-fatty-acid-CoA ligase family protein
  2. NM_170615.2NP_724695.1  Acyl-CoA synthetase long-chain, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724695.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86NS4, Q8T3L1, Q9V4W4
    Related
    FBpp0087779
    Conserved Domains (2) summary
    cd05927
    Location:129713
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    PLN02387
    Location:82714
    PLN02387; long-chain-fatty-acid-CoA ligase family protein
  3. NM_143777.3NP_652034.2  Acyl-CoA synthetase long-chain, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_652034.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86NS4, Q8T3L1, Q9V4W4
    Related
    FBpp0087780
    Conserved Domains (2) summary
    cd05927
    Location:129713
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    PLN02387
    Location:82714
    PLN02387; long-chain-fatty-acid-CoA ligase family protein
  4. NM_001014512.2NP_001014512.1  Acyl-CoA synthetase long-chain, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014512.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z7H2, Q86NS4
    Conserved Domains (2) summary
    cd05927
    Location:131715
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    PLN02387
    Location:84716
    PLN02387; long-chain-fatty-acid-CoA ligase family protein
  5. NM_001014510.2NP_001014510.1  Acyl-CoA synthetase long-chain, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014510.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z7H3, Q86NS4
    Conserved Domains (2) summary
    cd05927
    Location:121705
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    PLN02387
    Location:74706
    PLN02387; long-chain-fatty-acid-CoA ligase family protein
  6. NM_001014508.2NP_001014508.1  Acyl-CoA synthetase long-chain, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014508.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86NS4, Q8T3L1, Q9V4W4
    Conserved Domains (2) summary
    cd05927
    Location:129713
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    PLN02387
    Location:82714
    PLN02387; long-chain-fatty-acid-CoA ligase family protein
  7. NM_001014509.2NP_001014509.1  Acyl-CoA synthetase long-chain, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014509.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z7H3, Q86NS4
    Conserved Domains (2) summary
    cd05927
    Location:121705
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    PLN02387
    Location:74706
    PLN02387; long-chain-fatty-acid-CoA ligase family protein
  8. NM_001273881.1NP_001260810.1  Acyl-CoA synthetase long-chain, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260810.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KFE4, Q86NS4
    Conserved Domains (2) summary
    cd05927
    Location:142726
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    PLN02387
    Location:95727
    PLN02387; long-chain-fatty-acid-CoA ligase family protein
  9. NM_170616.2NP_724696.1  Acyl-CoA synthetase long-chain, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724696.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z7H3, Q86NS4
    Related
    FBpp0087781
    Conserved Domains (2) summary
    cd05927
    Location:121705
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    PLN02387
    Location:74706
    PLN02387; long-chain-fatty-acid-CoA ligase family protein
  10. NM_001014507.2NP_001014507.1  Acyl-CoA synthetase long-chain, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014507.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z7H3, Q86NS4
    Conserved Domains (2) summary
    cd05927
    Location:121705
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    PLN02387
    Location:74706
    PLN02387; long-chain-fatty-acid-CoA ligase family protein