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CBLB Cbl proto-oncogene B [ Pan troglodytes (chimpanzee) ]

Gene ID: 460566, updated on 27-Jun-2020

Summary

Official Symbol
CBLBprovided by VGNC
Official Full Name
Cbl proto-oncogene Bprovided by VGNC
Primary source
VGNC:VGNC:10371
Locus tag
CK820_G0016315
See related
Ensembl:ENSPTRG00000015184
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs

Genomic context

See CBLB in Genome Data Viewer
Location:
chromosome: 3
Exon count:
23
Annotation release Status Assembly Chr Location
105 current Clint_PTRv2 (GCF_002880755.1) 3 NC_036882.1 (103840807..104055424, complement)
104 previous assembly Pan_tro 3.0 (GCF_000001515.7) 3 NC_006490.4 (108540960..108755690, complement)
103 previous assembly Pan_troglodytes-2.1.4 (GCF_000001515.6) 3 NC_006490.3 (108883635..109098782, complement)

Chromosome 3 - NC_036882.1Genomic Context describing neighboring genes Neighboring gene ezrin pseudogene Neighboring gene activated leukocyte cell adhesion molecule Neighboring gene uncharacterized LOC107970499 Neighboring gene uncharacterized LOC107970500

Genomic regions, transcripts, and products

Pathways from PubChem

General gene information

Markers

Homology

General protein information

Preferred Names
E3 ubiquitin-protein ligase CBL-B
Names
Cas-Br-M (murine) ecotropic retroviral transforming sequence b
Cbl proto-oncogene B, E3 ubiquitin protein ligase
Cbl proto-oncogene, E3 ubiquitin protein ligase B
XP_003309960.1
XP_009444362.1
XP_009444363.1
XP_009444364.1
XP_009444365.1
XP_009444366.1
XP_016797076.1
XP_016797077.1
XP_016797078.1
XP_016797079.1
XP_016797080.1
XP_016797081.1
XP_016797082.1
XP_016797083.1
XP_016797084.1

NCBI Reference Sequences (RefSeq)

RefSeqs of Annotated Genomes: Pan troglodytes Annotation Release 105 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Clint_PTRv2 Primary Assembly

Genomic

  1. NC_036882.1 Reference Clint_PTRv2 Primary Assembly

    Range
    103840807..104055424 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_016941587.2XP_016797076.1  E3 ubiquitin-protein ligase CBL-B isoform X1

    UniProtKB/TrEMBL
    H2QN18
    Conserved Domains (5) summary
    cd09920
    Location:248344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd14392
    Location:931971
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44167
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:171254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    cd16709
    Location:354419
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
  2. XM_016941591.1XP_016797080.1  E3 ubiquitin-protein ligase CBL-B isoform X4

    Conserved Domains (5) summary
    cd09920
    Location:248344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd14392
    Location:838878
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44167
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:171254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    cd16709
    Location:354419
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
  3. XM_016941589.1XP_016797078.1  E3 ubiquitin-protein ligase CBL-B isoform X3

    Conserved Domains (5) summary
    cd09920
    Location:248344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd14392
    Location:882922
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44167
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:171254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    cd16709
    Location:354419
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
  4. XM_016941588.1XP_016797077.1  E3 ubiquitin-protein ligase CBL-B isoform X2

    Conserved Domains (5) summary
    cd09920
    Location:248344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd14392
    Location:887927
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44167
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:171254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    cd16709
    Location:354419
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
  5. XM_009446087.2XP_009444362.1  E3 ubiquitin-protein ligase CBL-B isoform X1

    See identical proteins and their annotated locations for XP_009444362.1

    UniProtKB/TrEMBL
    H2QN18
    Conserved Domains (5) summary
    cd09920
    Location:248344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd14392
    Location:931971
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44167
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:171254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    cd16709
    Location:354419
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
  6. XM_009446088.3XP_009444363.1  E3 ubiquitin-protein ligase CBL-B isoform X1

    See identical proteins and their annotated locations for XP_009444363.1

    UniProtKB/TrEMBL
    H2QN18
    Conserved Domains (5) summary
    cd09920
    Location:248344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd14392
    Location:931971
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44167
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:171254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    cd16709
    Location:354419
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
  7. XM_016941595.2XP_016797084.1  E3 ubiquitin-protein ligase CBL-B isoform X9

    Conserved Domains (5) summary
    cd09920
    Location:276372
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd14392
    Location:910950
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:72195
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:199282
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    cd16709
    Location:382447
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
  8. XM_016941594.2XP_016797083.1  E3 ubiquitin-protein ligase CBL-B isoform X8

    Conserved Domains (5) summary
    cd09920
    Location:276372
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd14392
    Location:959999
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:72195
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:199282
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    cd16709
    Location:382447
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
  9. XM_009446091.2XP_009444366.1  E3 ubiquitin-protein ligase CBL-B isoform X5

    Conserved Domains (5) summary
    cd09920
    Location:96192
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:221263
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:779819
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:115
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:19102
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
  10. XM_016941593.2XP_016797082.1  E3 ubiquitin-protein ligase CBL-B isoform X7

  11. XM_016941592.2XP_016797081.1  E3 ubiquitin-protein ligase CBL-B isoform X6

  12. XM_016941590.1XP_016797079.1  E3 ubiquitin-protein ligase CBL-B isoform X4

    Conserved Domains (5) summary
    cd09920
    Location:248344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd14392
    Location:838878
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44167
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:171254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    cd16709
    Location:354419
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
  13. XM_009446090.2XP_009444365.1  E3 ubiquitin-protein ligase CBL-B isoform X3

    Related
    ENSPTRP00000084421.1, ENSPTRT00000099393.1
    Conserved Domains (5) summary
    cd09920
    Location:248344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd14392
    Location:882922
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44167
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:171254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    cd16709
    Location:354419
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
  14. XM_009446089.2XP_009444364.1  E3 ubiquitin-protein ligase CBL-B isoform X2

    Related
    ENSPTRP00000071518.1, ENSPTRT00000076537.1
    Conserved Domains (5) summary
    cd09920
    Location:248344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd14392
    Location:887927
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44167
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:171254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    cd16709
    Location:354419
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
  15. XM_003309912.3XP_003309960.1  E3 ubiquitin-protein ligase CBL-B isoform X1

    See identical proteins and their annotated locations for XP_003309960.1

    UniProtKB/TrEMBL
    H2QN18
    Related
    ENSPTRP00000026201.2, ENSPTRT00000028392.3
    Conserved Domains (5) summary
    cd09920
    Location:248344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd14392
    Location:931971
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44167
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:171254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    cd16709
    Location:354419
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
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