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MYBL2 MYB proto-oncogene like 2 [ Homo sapiens (human) ]

Gene ID: 4605, updated on 12-Aug-2018
Official Symbol
MYBL2provided by HGNC
Official Full Name
MYB proto-oncogene like 2provided by HGNC
Primary source
HGNC:HGNC:7548
See related
Ensembl:ENSG00000101057 MIM:601415; Vega:OTTHUMG00000033062
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BMYB; B-MYB
Summary
The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]
Expression
Biased expression in bone marrow (RPKM 29.8), lymph node (RPKM 25.5) and 11 other tissues See more
Orthologs
See MYBL2 in Genome Data Viewer
Location:
20q13.12
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 20 NC_000020.11 (43667019..43716496)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (42295659..42345136)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene intraflagellar transport 52 Neighboring gene ribosomal protein L27a pseudogene Neighboring gene uncharacterized LOC101927200 Neighboring gene uncharacterized LOC107985441 Neighboring gene gametocyte specific factor 1 like

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Cell Cycle, organism-specific biosystem (from REACTOME)
    Cell Cycle, organism-specific biosystem
    Cell Cycle
  • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
    Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
  • E2F transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
    E2F transcription factor network, organism-specific biosystem
    E2F transcription factor network
  • EGF/EGFR Signaling Pathway, organism-specific biosystem (from WikiPathways)
    EGF/EGFR Signaling Pathway, organism-specific biosystemEpidermal growth factor receptor (EGFR) also known as ErbB1/HER1 is a member of the ErbB family of receptor tyrosine kinases which also includes ErbB2 (Neu, HER2), ErbB3 (HER3) and ErbB4 (HER4). Sev...
  • G0 and Early G1, organism-specific biosystem (from REACTOME)
    G0 and Early G1, organism-specific biosystemIn G0 and early G1 in quiescent cells, p130 (RBL2) bound to E2F4 or E2F5 and either DP1 or DP2, associates with the MuvB complex, forming an evolutionarily conserved DREAM complex, that represses tra...
  • G2/M Transition, organism-specific biosystem (from REACTOME)
    G2/M Transition, organism-specific biosystemCyclin A can also form complexes with Cdc2 (Cdk1). Together with three B-type cyclins, Cdc2 (Cdk1) regulates the transition from G2 into mitosis. These complexes are activated by dephosphorylation of...
  • Gastric Cancer Network 1, organism-specific biosystem (from WikiPathways)
    Gastric Cancer Network 1, organism-specific biosystemNetwork generated by mapping candidate oncogenes and tumor suppressor genes identified by integrated analysis of expression array and aCGH data. Networks generated by Ingenuity Pathway Analysis.
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
  • HTLV-I infection, organism-specific biosystem (from KEGG)
    HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • HTLV-I infection, conserved biosystem (from KEGG)
    HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • Mitotic G1-G1/S phases, organism-specific biosystem (from REACTOME)
    Mitotic G1-G1/S phases, organism-specific biosystem
    Mitotic G1-G1/S phases
  • Mitotic G2-G2/M phases, organism-specific biosystem (from REACTOME)
    Mitotic G2-G2/M phases, organism-specific biosystem
    Mitotic G2-G2/M phases
  • Polo-like kinase mediated events, organism-specific biosystem (from REACTOME)
    Polo-like kinase mediated events, organism-specific biosystemAt mitotic entry, Plk1 phosphorylates and activates Cdc25C phosphatase, whereas it phosphorylates and down-regulates Wee1A (Watanabe et al. 2004). Plk1 also phosphorylates and inhibits Myt1 activit...
  • TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation, organism-specific biosystem (from REACTOME)
    TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation, organism-specific biosystemDuring retinoic acid-induced cell differentiation, TFAP2A, in complex with NPM1 (nucleophosmin), represses transcription of HSPD1 (Hsp60), NOP2 (p120) and MYBL2 (b-Myb). The repression of gene expres...
  • Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors, organism-specific biosystem (from REACTOME)
    Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors, organism-specific biosystemThe AP-2 (TFAP2) family of transcription factors includes five proteins in mammals: TFAP2A (AP-2 alpha), TFAP2B (AP-2 beta), TFAP2C (AP-2 gamma), TFAP2D (AP-2 delta) and TFAP2E (AP-2 epsilon). The AP...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC15600

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cellular response to leukemia inhibitory factor IEA
Inferred from Electronic Annotation
more info
 
mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cell cycle TAS
Traceable Author Statement
more info
 
regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 
transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Myb complex IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
Preferred Names
myb-related protein B
Names
myb-like protein 2
v-myb avian myeloblastosis viral oncogene homolog-like 2
v-myb myeloblastosis viral oncogene homolog-like 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278610.1NP_001265539.1  myb-related protein B isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AA586734, AK303249, AL121886, BC007585, DC395847
    Consensus CDS
    CCDS63276.1
    UniProtKB/Swiss-Prot
    P10244
    Related
    ENSP00000380072.4, ENST00000396863.8
    Conserved Domains (4) summary
    smart00717
    Location:59107
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    pfam00249
    Location:59105
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam09316
    Location:427570
    Cmyb_C; C-myb, C-terminal
    pfam13921
    Location:3970
    Myb_DNA-bind_6; Myb-like DNA-binding domain
  2. NM_002466.3NP_002457.1  myb-related protein B isoform 1

    See identical proteins and their annotated locations for NP_002457.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA586734, AL121886, BC007585, DC395847
    Consensus CDS
    CCDS13322.1
    UniProtKB/Swiss-Prot
    P10244
    Related
    ENSP00000217026.4, OTTHUMP00000031719, ENST00000217026.4, OTTHUMT00000080408
    Conserved Domains (4) summary
    smart00717
    Location:83131
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    pfam00249
    Location:83129
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam09316
    Location:451594
    Cmyb_C; C-myb, C-terminal
    pfam13921
    Location:3494
    Myb_DNA-bind_6; Myb-like DNA-binding domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p12 Primary Assembly

    Range
    43667019..43716496
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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