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mr morula [ Drosophila melanogaster (fruit fly) ]

Gene ID: 45906, updated on 7-Aug-2025
Official Symbol
mrprovided by FlyBase
Official Full Name
morulaprovided by FlyBase
Primary source
FLYBASE:FBgn0002791
Locus tag
Dmel_CG3060
See related
AllianceGenome:FB:FBgn0002791
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Apc2; APC2; APC2/mr; CG3060; dAPC2; Dmel\CG3060; Mr; MR
Summary
Predicted to enable ubiquitin protein ligase binding activity. Involved in modulation of chemical synaptic transmission and negative regulation of synaptic assembly at neuromuscular junction. Part of anaphase-promoting complex. Orthologous to human ANAPC2 (anaphase promoting complex subunit 2). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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Location:
60A15-60A15; 2-105 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23972431..23975408)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19859954..19862931)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene orange Neighboring gene uncharacterized protein Neighboring gene Protein phosphatase 1 regulatory subunit 15 Neighboring gene Sox box protein 14 Neighboring gene Peptidylglycine-alpha-hydroxylating monooxygenase

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The Drosophila MCPH1-B isoform is a substrate of the APCCdh1 E3 ubiquitin ligase complex. Hainline SG, et al. Biol Open, 2014 Jun 27. PMID 24972868, Free PMC Article
  2. Gcn5 determines the fate of Drosophila germline stem cells through degradation of Cyclin A. Liu T, et al. FASEB J, 2017 May. PMID 28188175
  3. Bruno inhibits the expression of mitotic cyclins during the prophase I meiotic arrest of Drosophila oocytes. Sugimura I, et al. Dev Cell, 2006 Jan. PMID 16399084
  4. lemmingA encodes the Apc11 subunit of the APC/C in Drosophila melanogaster that forms a ternary complex with the E2-C type ubiquitin conjugating enzyme, Vihar and Morula/Apc2. Nagy O, et al. Cell Div, 2012 Mar 14. PMID 22417125, Free PMC Article
  5. The careful control of Polo kinase by APC/C-Ube2C ensures the intercellular transport of germline centrosomes during Drosophila oogenesis. Braun AL, et al. Open Biol, 2021 Jun. PMID 34186008, Free PMC Article

See all (71) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. mr encodes the APC2 subunit of the anaphase promoting complex/cyclosome
    Title: The anaphase promoting complex/cyclosome is required during development for modified cell cycles.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in anaphase-promoting complex-dependent catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in metaphase/anaphase transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of synaptic assembly at neuromuscular junction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein K11-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell cycle TAS
Traceable Author Statement
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of anaphase-promoting complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of anaphase-promoting complex TAS
Traceable Author Statement
more info
 PubMed 
part_of ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
morula
Names
CG3060-PA
mr-PA

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    23972431..23975408
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_138018.3 → NP_611862.1  morula

    See identical proteins and their annotated locations for NP_611862.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W1E5
    Related
    FBpp0072065
    Conserved Domains (2) summary
    smart01013
    Location:741 → 800
    APC2; Anaphase promoting complex (APC) subunit 2
    smart00182
    Location:494 → 632
    CULLIN; Cullin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95TK2 Q95TK2
Q9W1E5 Q9W1E5

Gene LinkOut

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