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MUC6 mucin 6, oligomeric mucus/gel-forming [ Homo sapiens (human) ]

Gene ID: 4588, updated on 26-Jul-2021

Summary

Official Symbol
MUC6provided by HGNC
Official Full Name
mucin 6, oligomeric mucus/gel-formingprovided by HGNC
Primary source
HGNC:HGNC:7517
See related
Ensembl:ENSG00000184956 MIM:158374
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MUC-6
Summary
This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. [provided by RefSeq, Dec 2016]
Expression
Biased expression in stomach (RPKM 174.6) and duodenum (RPKM 41.3) See more
Orthologs
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Genomic context

See MUC6 in Genome Data Viewer
Location:
11p15.5
Exon count:
33
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (1012823..1036718, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (1012823..1036718, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 4982 Neighboring gene adaptor related protein complex 2 subunit alpha 2 Neighboring gene RNA, U6 small nuclear 1025, pseudogene Neighboring gene long intergenic non-protein coding RNA 2688 Neighboring gene uncharacterized LOC107987157

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables extracellular matrix structural constituent NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in maintenance of gastrointestinal epithelium NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi lumen TAS
Traceable Author Statement
more info
 
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
mucin-6
Names
gastric mucin-6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052845.1 RefSeqGene

    Range
    4989..28884
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005961.3NP_005952.2  mucin-6 precursor

    See identical proteins and their annotated locations for NP_005952.2

    Status: REVIEWED

    Source sequence(s)
    AC139749
    Consensus CDS
    CCDS44513.1
    UniProtKB/Swiss-Prot
    Q6W4X9
    Related
    ENSP00000406861.2, ENST00000421673.7
    Conserved Domains (8) summary
    PHA03255
    Location:21882343
    PHA03255; BDLF3; Provisional
    smart00041
    Location:23512434
    CT; C-terminal cystine knot-like domain (CTCK)
    smart00215
    Location:359403
    VWC_out; von Willebrand factor (vWF) type C domain
    smart00216
    Location:386549
    VWD; von Willebrand factor (vWF) type D domain
    pfam00094
    Location:8681017
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:302357
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:10571127
    C8; C8 domain
    cl17735
    Location:829886
    VWC; von Willebrand factor type C domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    1012823..1036718 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_015148966.1 Reference GRCh38.p13 PATCHES

    Range
    280..24175 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_2

Genomic

  1. NT_187656.1 Reference GRCh38.p13 ALT_REF_LOCI_2

    Range
    75566..106283 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_3

Genomic

  1. NT_187681.1 Reference GRCh38.p13 ALT_REF_LOCI_3

    Range
    82414..111111 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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