TOP1 DNA topoisomerase I [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: TOP1provided by VGNC
Official Full Name: DNA topoisomerase Iprovided by VGNC
Primary source: VGNC:VGNC:10014
Locus tag: CK820_G0020106
See related: Ensembl:ENSPTRG00000013498
Gene type: protein coding
RefSeq status: MODEL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
105	current	Clint_PTRv2 (GCF_002880755.1)	20	NC_036899.1 (40606041..40702010)
104	previous assembly	Pan_tro 3.0 (GCF_000001515.7)	20	NC_006487.4 (42638518..42734513)
103	previous assembly	Pan_troglodytes-2.1.4 (GCF_000001515.6)	20	NC_006487.3 (37959501..38056815)

Chromosome 20 - NC_036899.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D20S758 (e-PCR)
- UniSTS:81173

STS-AA009654 (e-PCR)
- UniSTS:68887

Z94472 (e-PCR)
- UniSTS:24366

PMC133732P2 (e-PCR)
- UniSTS:270642

PMC133732P3 (e-PCR)
- UniSTS:270643

PMC133732P4 (e-PCR)
- UniSTS:270644

RH71031 (e-PCR)
- UniSTS:46134

WI-18785 (e-PCR)
- UniSTS:33893

SHGC-12857 (e-PCR)
- UniSTS:33894

RH36224 (e-PCR)
- UniSTS:5235

AL031477 (e-PCR)
- UniSTS:62585

AL023695 (e-PCR)
- UniSTS:30660

RH71013 (e-PCR)
- UniSTS:23006

SHGC-78852 (e-PCR)
- UniSTS:100836

Homology

Homologs of the TOP1 gene: The TOP1 gene is conserved in human, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
Orthologs from Annotation Pipeline: 335 organisms have orthologs with human gene TOP1
Orthologs

General protein information

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Preferred Names: DNA topoisomerase 1

Names: topoisomerase (DNA) I

XP_016793406.1

EC 5.6.2.2

XP_514649.2

EC 5.6.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Pan troglodytes Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Clint_PTRv2 Primary Assembly

Genomic

NC_036899.1 Reference Clint_PTRv2 Primary Assembly

Range

40606041..40702010

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_514649.6 → XP_514649.2 DNA topoisomerase 1 isoform X1

See identical proteins and their annotated locations for XP_514649.2

UniProtKB/TrEMBL

H2QKC9

Related

ENSPTRP00000023175.6, ENSPTRT00000025111.7

Conserved Domains (2) summary

smart00435
Location:360 → 737

TOPEUc; DNA Topoisomerase I (eukaryota)

pfam02919
Location:215 → 429

Topoisom_I_N; Eukaryotic DNA topoisomerase I, DNA binding fragment
XM_016937917.2 → XP_016793406.1 DNA topoisomerase 1 isoform X2

Conserved Domains (4) summary

smart00435
Location:114 → 491

TOPEUc; DNA Topoisomerase I (eukaryota)

cd03488
Location:1 → 184

Topoisomer_IB_N_htopoI_like; Topoisomer_IB_N_htopoI_like : N-terminal DNA binding fragment found in eukaryotic DNA topoisomerase (topo) IB proteins similar to the monomeric yeast and human topo I. Topo I enzymes are divided into: topo type IA (bacterial) and type IB (eukaryotic). ...

pfam01028
Location:186 → 389

Topoisom_I; Eukaryotic DNA topoisomerase I, catalytic core

pfam14370
Location:449 → 517

Topo_C_assoc; C-terminal topoisomerase domain