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TOP1 DNA topoisomerase I [ Pan troglodytes (chimpanzee) ]

Gene ID: 458252, updated on 5-Oct-2018

Summary

Official Symbol
TOP1provided by VGNC
Official Full Name
DNA topoisomerase Iprovided by VGNC
Primary source
VGNC:VGNC:10014
Locus tag
CK820_G0020106
See related
Ensembl:ENSPTRG00000013498
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs

Genomic context

See TOP1 in Genome Data Viewer
Location:
chromosome: 20
Exon count:
22
Annotation release Status Assembly Chr Location
105 current Clint_PTRv2 (GCF_002880755.1) 20 NC_036899.1 (40606041..40702010)
103 previous assembly Pan_troglodytes-2.1.4 (GCF_000001515.6) 20 NC_006487.3 (37959501..38056815)

Chromosome 20 - NC_036899.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107970025 Neighboring gene uncharacterized LOC107970026 Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC107970027 Neighboring gene phospholipase C gamma 1 Neighboring gene cholinephosphotransferase 1 pseudogene Neighboring gene zinc fingers and homeoboxes 3

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific RNA-sequencing for ten non-human primate species
  • Description: Total RNA sequencing of fifteen different tissues for ten non-human primates
  • BioProject: PRJNA271912
  • Publication: PMID 25392405
  • Analysis date: Tue Apr 3 07:13:10 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

General gene information

Markers

Homology

General protein information

Preferred Names
DNA topoisomerase 1
Names
topoisomerase (DNA) I
XP_016793406.1
XP_514649.2

NCBI Reference Sequences (RefSeq)

RefSeqs of Annotated Genomes: Pan troglodytes Annotation Release 105 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Clint_PTRv2 Primary Assembly

Genomic

  1. NC_036899.1 Reference Clint_PTRv2 Primary Assembly

    Range
    40606041..40702010
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_514649.6XP_514649.2  DNA topoisomerase 1 isoform X1

    See identical proteins and their annotated locations for XP_514649.2

    UniProtKB/TrEMBL
    H2QKC9
    Related
    ENSPTRP00000023175.6, ENSPTRT00000025111.7
    Conserved Domains (3) summary
    smart00435
    Location:360737
    TOPEUc; DNA Topoisomerase I (eukaryota)
    cd03488
    Location:216430
    Topoisomer_IB_N_htopoI_like; Topoisomer_IB_N_htopoI_like : N-terminal DNA binding fragment found in eukaryotic DNA topoisomerase (topo) IB proteins similar to the monomeric yeast and human topo I. Topo I enzymes are divided into: topo type IA (bacterial) and type IB (eukaryotic). ...
    pfam10243
    Location:19145
    MIP-T3; Microtubule-binding protein MIP-T3
  2. XM_016937917.2XP_016793406.1  DNA topoisomerase 1 isoform X2

    Conserved Domains (4) summary
    smart00435
    Location:114491
    TOPEUc; DNA Topoisomerase I (eukaryota)
    cd03488
    Location:1184
    Topoisomer_IB_N_htopoI_like; Topoisomer_IB_N_htopoI_like : N-terminal DNA binding fragment found in eukaryotic DNA topoisomerase (topo) IB proteins similar to the monomeric yeast and human topo I. Topo I enzymes are divided into: topo type IA (bacterial) and type IB (eukaryotic). ...
    pfam01028
    Location:186389
    Topoisom_I; Eukaryotic DNA topoisomerase I, catalytic core
    pfam14370
    Location:449517
    Topo_C_assoc; C-terminal topoisomerase domain
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