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SRC SRC proto-oncogene, non-receptor tyrosine kinase [ Pan troglodytes (chimpanzee) ]

Gene ID: 458229, updated on 3-Dec-2024

Summary

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Official Symbol
SRCprovided by VGNC
Official Full Name
SRC proto-oncogene, non-receptor tyrosine kinaseprovided by VGNC
Primary source
VGNC:VGNC:10269
Locus tag
CK820_G0020172
See related
Ensembl:ENSPTRG00000013474
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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See SRC in Genome Data Viewer
Location:
chromosome: 21
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 21 NC_072419.2 (43566108..43643291)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 20 NC_072418.1 (43597851..43675038)

Chromosome 21 - NC_072419.2Genomic Context describing neighboring genes Neighboring gene maestro heat like repeat family member 8 Neighboring gene ribophorin II Neighboring gene mannosidase beta like Neighboring gene large ribosomal subunit protein eL8-like Neighboring gene uncharacterized LOC134809214

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in bone resorption IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in epidermal growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of extrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of intrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in osteoclast development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in progesterone receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extrinsic component of cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
proto-oncogene tyrosine-protein kinase Src
Names
proto-oncogene tyrosine-protein kinase SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072419.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    43566108..43643291
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054674765.2 → XP_054530740.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    UniProtKB/TrEMBL
    H2QKB4

  2. XM_054674763.2 → XP_054530738.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    UniProtKB/TrEMBL
    H2QKB4

  3. XM_016937897.4 → XP_016793386.1  proto-oncogene tyrosine-protein kinase Src isoform X3

    UniProtKB/TrEMBL
    A0A2J8MKT3, A0A6D2Y674, H2QKB4, K7B763
    Related
    ENSPTRP00000066326.1
    Conserved Domains (3) summary
    cd10365
    Location:147 → 247
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:88 → 143
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:260 → 536
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src

  4. XM_063803332.1 → XP_063659402.1  proto-oncogene tyrosine-protein kinase Src isoform X3

    UniProtKB/TrEMBL
    A0A2J8MKT3, A0A6D2Y674, H2QKB4, K7B763

  5. XM_016937893.4 → XP_016793382.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    UniProtKB/TrEMBL
    H2QKB4
    Conserved Domains (3) summary
    cd10365
    Location:164 → 264
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:88 → 160
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:277 → 553
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src

  6. XM_016937896.4 → XP_016793385.1  proto-oncogene tyrosine-protein kinase Src isoform X2

    UniProtKB/TrEMBL
    A0A2I3SIH9, A0A2J8MKV0, A0A6D2WAT7, H2QKB4
    Related
    ENSPTRP00000076797.1
    Conserved Domains (3) summary
    cd10365
    Location:153 → 253
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:88 → 149
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:266 → 542
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src

  7. XM_016937895.4 → XP_016793384.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    UniProtKB/TrEMBL
    H2QKB4
    Conserved Domains (3) summary
    cd10365
    Location:164 → 264
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:88 → 160
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:277 → 553
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src

  8. XM_054674766.2 → XP_054530741.1  proto-oncogene tyrosine-protein kinase Src isoform X3

    UniProtKB/TrEMBL
    A0A2J8MKT3, A0A6D2Y674, H2QKB4, K7B763

  9. XM_063803330.1 → XP_063659400.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    UniProtKB/TrEMBL
    H2QKB4

  10. XM_063803331.1 → XP_063659401.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    UniProtKB/TrEMBL
    H2QKB4
Nucleotide Protein
Heading Accession and Version

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