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ThrRS Threonyl-tRNA synthetase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 45784, updated on 19-Aug-2018

Summary

Official Symbol
ThrRSprovided by FlyBase
Official Full Name
Threonyl-tRNA synthetaseprovided by FlyBase
Primary source
FLYBASE:FBgn0027081
Locus tag
Dmel_CG5353
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster (old-lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
42/3; Aats-thr; CG5353; Dmel\CG5353; l(2)k04203; P539; threonyl-tRNA synthetase; TRS

Genomic context

See ThrRS in Genome Data Viewer
Location:
33C4-33C4; 2-46 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.13 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (12103751..12107170)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (12103751..12107170)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Methyltransferase 2 Neighboring gene Ced-12 Neighboring gene patsas Neighboring gene Rab6 Neighboring gene Phaedra 1

Genomic regions, transcripts, and products

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
threonine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
threonine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
 
threonine-tRNA ligase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
threonyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
threonyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
 
threonyl-tRNA aminoacylation TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
mitochondrion TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
Threonyl-tRNA synthetase
Names
CG5353-PA
CG5353-PB
CG5353-PC
CG5353-PD
ThrRS-PA
ThrRS-PB
ThrRS-PC
ThrRS-PD
threonyl-tRNA synthetase
NP_001285868.1
NP_524839.3
NP_723725.1
NP_723726.1

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    12103751..12107170
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298939.1NP_001285868.1  Threonyl-tRNA synthetase, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285868.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VKB0
    Related
    FBpp0312095.1, FBtr0346436
    Conserved Domains (5) summary
    cd01667
    Location:109170
    TGS_ThrRS_N; TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and ...
    PLN02908
    Location:79740
    PLN02908; threonyl-tRNA synthetase
    smart00863
    Location:276323
    tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain
    cd00771
    Location:347643
    ThrRS_core; Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent ...
    cd00860
    Location:643734
    ThrRS_anticodon; ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is ...
  2. NM_164994.3NP_723725.1  Threonyl-tRNA synthetase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723725.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VKB0
    Related
    FBpp0079914.1, FBtr0080332
    Conserved Domains (5) summary
    cd01667
    Location:109170
    TGS_ThrRS_N; TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and ...
    PLN02908
    Location:79740
    PLN02908; threonyl-tRNA synthetase
    smart00863
    Location:276323
    tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain
    cd00771
    Location:347643
    ThrRS_core; Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent ...
    cd00860
    Location:643734
    ThrRS_anticodon; ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is ...
  3. NM_080100.6NP_524839.3  Threonyl-tRNA synthetase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524839.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IP94
    Related
    FBpp0079913.1, FBtr0080331
    Conserved Domains (5) summary
    cd01667
    Location:52113
    TGS_ThrRS_N; TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and ...
    PLN02908
    Location:1683
    PLN02908; threonyl-tRNA synthetase
    smart00863
    Location:219266
    tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain
    cd00771
    Location:290586
    ThrRS_core; Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent ...
    cd00860
    Location:586677
    ThrRS_anticodon; ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is ...
  4. NM_164995.2NP_723726.1  Threonyl-tRNA synthetase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723726.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IP94
    Related
    FBpp0079915.1, FBtr0080333
    Conserved Domains (5) summary
    cd01667
    Location:52113
    TGS_ThrRS_N; TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and ...
    PLN02908
    Location:1683
    PLN02908; threonyl-tRNA synthetase
    smart00863
    Location:219266
    tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain
    cd00771
    Location:290586
    ThrRS_core; Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent ...
    cd00860
    Location:586677
    ThrRS_anticodon; ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is ...
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