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HMGCL 3-hydroxy-3-methylglutaryl-CoA lyase [ Pan troglodytes (chimpanzee) ]

Gene ID: 456624, updated on 12-Apr-2023

Summary

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Official Symbol
HMGCLprovided by VGNC
Official Full Name
3-hydroxy-3-methylglutaryl-CoA lyaseprovided by VGNC
Primary source
VGNC:VGNC:1261
Locus tag
CK820_G0041608
See related
Ensembl:ENSPTRG00000000339
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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See HMGCL in Genome Data Viewer
Location:
chromosome: 1
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_04 current NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 1 NC_072398.1 (24079524..24117879, complement)

Chromosome 1 - NC_072398.1Genomic Context describing neighboring genes Neighboring gene lysophospholipase 2 Neighboring gene UDP-galactose-4-epimerase Neighboring gene alpha-L-fucosidase 1 Neighboring gene small nucleolar RNA U13 Neighboring gene cannabinoid receptor 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_072398.1 Chromosome 1 Reference NHGRI_mPanTro3-v1.1-hic.freeze_pri

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

General protein information

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Preferred Names
hydroxymethylglutaryl-CoA lyase, mitochondrial
Names
3-hydroxymethyl-3-methylglutaryl-CoA lyase
3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria)
XP_001166273.1
XP_003307921.1
XP_009448954.1
XP_009448958.1
XP_016811773.1
XP_054519862.1
XP_054519863.1
XP_054519864.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.1-RS_2023_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v1.1-hic.freeze_pri

Genomic

  1. NC_072398.1 Reference NHGRI_mPanTro3-v1.1-hic.freeze_pri

    Range
    24079524..24117879 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_016956284.3 → XP_016811773.1  hydroxymethylglutaryl-CoA lyase, mitochondrial isoform X4

    Conserved Domains (2) summary
    cd07938
    Location:26 → 299
    DRE_TIM_HMGL; 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain
    pfam00682
    Location:23 → 297
    HMGL-like; HMGL-like

  2. XM_054663889.1 → XP_054519864.1  hydroxymethylglutaryl-CoA lyase, mitochondrial isoform X5

  3. XM_054663887.1 → XP_054519862.1  hydroxymethylglutaryl-CoA lyase, mitochondrial isoform X4

  4. XM_054663888.1 → XP_054519863.1  hydroxymethylglutaryl-CoA lyase, mitochondrial isoform X4

  5. XM_009450683.3 → XP_009448958.1  hydroxymethylglutaryl-CoA lyase, mitochondrial isoform X2

    Conserved Domains (2) summary
    PLN02746
    Location:17 → 289
    PLN02746; hydroxymethylglutaryl-CoA lyase
    pfam00682
    Location:32 → 270
    HMGL-like; HMGL-like

  6. XM_003307873.4 → XP_003307921.1  hydroxymethylglutaryl-CoA lyase, mitochondrial isoform X3

    UniProtKB/TrEMBL
    A0A2J8K3V9, A0A6D2WL71
    Related
    ENSPTRP00000066234.1
    Conserved Domains (1) summary
    PLN02746
    Location:17 → 254
    PLN02746; hydroxymethylglutaryl-CoA lyase

  7. XM_001166273.5 → XP_001166273.1  hydroxymethylglutaryl-CoA lyase, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_001166273.1

    UniProtKB/TrEMBL
    A0A2J8K423, A0A6D2WYU0, H2PYB3
    Related
    ENSPTRP00000000589.4
    Conserved Domains (1) summary
    cd07938
    Location:35 → 308
    DRE_TIM_HMGL; 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain

  8. XM_009450679.4 → XP_009448954.1  hydroxymethylglutaryl-CoA lyase, mitochondrial isoform X5

    See identical proteins and their annotated locations for XP_009448954.1

    Conserved Domains (2) summary
    cd07938
    Location:10 → 283
    DRE_TIM_HMGL; 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain
    pfam00682
    Location:7 → 281
    HMGL-like; HMGL-like
Nucleotide Protein
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