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eIF4E1 eukaryotic translation initiation factor 4E1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 45525, updated on 26-Aug-2021

Summary

Official Symbol
eIF4E1provided by FlyBase
Official Full Name
eukaryotic translation initiation factor 4E1provided by FlyBase
Primary source
FLYBASE:FBgn0015218
Locus tag
Dmel_CG4035
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
0260/09; 0587/11; 0589/11; 0919/12; 1004/13; 2; 7238; CBP; CG4035; CT13384; CT39424; CT39426; D-eIF4E; deIF-4E; dEif-4e; deIF4E; dEif4e; Dmel\CG4035; eIF 4E; eif-4e; eif-4E; eIF-4e; eIF-4E; eIF-4E1; eIF-4E2; eIF-4EII; eif4e; eIF4e; eIF4E; Eif4e; Eif4E; EIF4E; eIF4E-1; eIF4E-1/2; eIF4E-2; eIF4EI; elF4E; IF4E; l(3)07238; l(3)67Af; l(3)S025007; l(3)S026009; l(3)S058711; l(3)S091912
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Genomic context

See eIF4E1 in Genome Data Viewer
Location:
67B4-67B4; 3-29 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.32 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9399618..9402460, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9392718..9395560, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene Cuticular protein 67B Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the eIF4E1 gene: The eIF4E1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, mosquito, C.elegans, A.thaliana, rice, and frog.
  • Orthologs

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA 7-methylguanosine cap binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA 7-methylguanosine cap binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA cap binding IDA
Inferred from Direct Assay
more info
PubMed 
enables eukaryotic initiation factor 4G binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables translation initiation factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables translation initiation factor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in RNA metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in translation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in translation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in translational initiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in translational initiation IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in P-body IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
part_of eukaryotic translation initiation factor 4F complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of eukaryotic translation initiation factor 4F complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of mRNA cap binding complex ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of messenger ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in muscle cell postsynaptic specialization IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuromuscular junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
eukaryotic translation initiation factor 4E1
Names
CG4035-PA
CG4035-PB
CG4035-PC
CG4035-PD
CG4035-PE
CG4035-PF
CG4035-PG
CG4035-PH
CG4035-PI
cap binding protein
eIF4E1-PA
eIF4E1-PB
eIF4E1-PC
eIF4E1-PD
eIF4E1-PE
eIF4E1-PF
eIF4E1-PG
eIF4E1-PH
eIF4E1-PI
eukaryotic initiation factor 4E
eukaryotic translation initiation factor 4E
lethal(3)67Af

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    9399618..9402460 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168333.2NP_729480.1  eukaryotic translation initiation factor 4E1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729480.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P48598
    Related
    FBpp0076216, FBtr0076488
    Conserved Domains (1) summary
    pfam01652
    Location:71228
    IF4E; Eukaryotic initiation factor 4E
  2. NM_080090.3NP_524829.1  eukaryotic translation initiation factor 4E1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524829.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P48598
    UniProtKB/TrEMBL
    M9PBZ9
    Related
    FBpp0076215, FBtr0076487
    Conserved Domains (1) summary
    pfam01652
    Location:82239
    IF4E; Eukaryotic initiation factor 4E
  3. NM_168335.2NP_729482.1  eukaryotic translation initiation factor 4E1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729482.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P48598
    UniProtKB/TrEMBL
    M9PBZ9
    Related
    FBpp0076217, FBtr0076489
    Conserved Domains (1) summary
    pfam01652
    Location:82239
    IF4E; Eukaryotic initiation factor 4E
  4. NM_001274698.1NP_001261627.1  eukaryotic translation initiation factor 4E1, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261627.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P48598
    UniProtKB/TrEMBL
    M9PBZ9
    Related
    FBpp0306017, FBtr0333885
    Conserved Domains (1) summary
    pfam01652
    Location:82239
    IF4E; Eukaryotic initiation factor 4E
  5. NM_168338.2NP_729485.1  eukaryotic translation initiation factor 4E1, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729485.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P48598
    UniProtKB/TrEMBL
    M9PBZ9
    Related
    FBpp0076219, FBtr0076491
    Conserved Domains (1) summary
    pfam01652
    Location:82239
    IF4E; Eukaryotic initiation factor 4E
  6. NM_168334.1NP_729481.1  eukaryotic translation initiation factor 4E1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729481.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P48598
    UniProtKB/TrEMBL
    M9PBZ9
    Related
    FBpp0076218, FBtr0076490
    Conserved Domains (1) summary
    pfam01652
    Location:82239
    IF4E; Eukaryotic initiation factor 4E
  7. NM_001274697.1NP_001261626.1  eukaryotic translation initiation factor 4E1, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261626.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P48598
    UniProtKB/TrEMBL
    M9PBZ9
    Related
    FBpp0306016, FBtr0333884
    Conserved Domains (1) summary
    pfam01652
    Location:82239
    IF4E; Eukaryotic initiation factor 4E
  8. NM_168336.2NP_729483.1  eukaryotic translation initiation factor 4E1, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729483.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P48598
    UniProtKB/TrEMBL
    M9PBZ9
    Related
    FBpp0076220, FBtr0076492
    Conserved Domains (1) summary
    pfam01652
    Location:82239
    IF4E; Eukaryotic initiation factor 4E
  9. NM_168337.2NP_729484.1  eukaryotic translation initiation factor 4E1, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729484.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P48598
    UniProtKB/TrEMBL
    M9PBZ9
    Related
    FBpp0076221, FBtr0076493
    Conserved Domains (1) summary
    pfam01652
    Location:82239
    IF4E; Eukaryotic initiation factor 4E
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