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MT-ND2 mitochondrially encoded NADH dehydrogenase 2 [ Homo sapiens (human) ]

Gene ID: 4536, updated on 13-May-2022

Summary

Official Symbol
MT-ND2provided by HGNC
Official Full Name
mitochondrially encoded NADH dehydrogenase 2provided by HGNC
Primary source
HGNC:HGNC:7456
See related
MIM:516001; AllianceGenome:HGNC:7456
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MTND2; ND2
Summary
Enables NADH dehydrogenase (ubiquinone) activity. Involved in mitochondrial electron transport, NADH to ubiquinone and mitochondrial respiratory chain complex I assembly. Part of mitochondrial respiratory chain complex I. Implicated in Leber hereditary optic neuropathy; multiple sclerosis; myocardial infarction; neurodegenerative disease (multiple); and urinary bladder cancer. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See MT-ND2 in Genome Data Viewer
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) MT (non-nuclear) NC_012920.1 (4470..5511)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) MT (non-nuclear) NC_012920.1 (4470..5511)

Chromosome MT - NC_012920.1Genomic Context describing neighboring genes Neighboring gene tRNA-Ile Neighboring gene tRNA-Gln Neighboring gene tRNA-Met Neighboring gene tRNA-Trp Neighboring gene tRNA-Ala

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
capsid gag The interaction of HIV-1 CA with human cellular NADH dehydrogenase 2 mitochondrial protein (MT-ND2) is identified by yeast two-hybrid screen PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables NADH dehydrogenase (ubiquinone) activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables NADH dehydrogenase (ubiquinone) activity NAS
Non-traceable Author Statement
more info
PubMed 
enables ionotropic glutamate receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
NADH dehydrogenase subunit 2
YP_003024027.1
  • TAA stop codon is completed by the addition of 3' A residues to the mRNA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_012920.1 Reference assembly

    Range
    4470..5511
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_003024027.1 NADH dehydrogenase subunit 2 (mitochondrion) [Homo sapiens]

    See identical proteins and their annotated locations for YP_003024027.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P03891
    UniProtKB/TrEMBL
    Q7GXY9
    Related
    ENSP00000355046.4
    Conserved Domains (1) summary
    MTH00105
    Location:1346
    ND2; NADH dehydrogenase subunit 2; Provisional