VhaPPA1-1 Vacuolar H[+] ATPase PPA1 subunit 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: VhaPPA1-1provided by FlyBase
Official Full Name: Vacuolar H[+] ATPase PPA1 subunit 1provided by FlyBase
Primary source: FLYBASE:FBgn0028662
Locus tag: Dmel_CG7007
See related: AllianceGenome:FB:FBgn0028662
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG7007; Dmel\CG7007; V0c''; Vha26; VhaPPA1; vhaPPA1-1
Summary: Predicted to contribute to proton-transporting ATPase activity, rotational mechanism. Involved in terminal branching, open tracheal system. Part of plasma membrane proton-transporting V-type ATPase complex. Is expressed in adult Malpighian tubule; adult head; and testis. Orthologous to human ATP6V0B (ATPase H+ transporting V0 subunit b). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (14902330..14904061, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (10728052..10729783, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables proton transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
contributes_to proton-transporting ATPase activity, rotational mechanism	IC Inferred by Curator more info	PubMed
enables proton-transporting ATPase activity, rotational mechanism	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in proton transmembrane transport	IC Inferred by Curator more info	PubMed
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in terminal branching, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of plasma membrane proton-transporting V-type ATPase complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of proton-transporting V-type ATPase, V0 domain	IEA Inferred from Electronic Annotation more info
part_of proton-transporting two-sector ATPase complex, proton-transporting domain	IEA Inferred from Electronic Annotation more info
part_of vacuolar proton-transporting V-type ATPase, V0 domain	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Names: CG7007-PA; CG7007-PB; V-ATPase proton pump; VhaPPA1-1-PA; VhaPPA1-1-PB

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The following sections contain reference sequences that belong to a specific genome build. Explain