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SP1 Sp1 transcription factor [ Pan troglodytes (chimpanzee) ]

Gene ID: 451939, updated on 21-May-2019

Summary

Official Symbol
SP1provided by VGNC
Official Full Name
Sp1 transcription factorprovided by VGNC
Primary source
VGNC:VGNC:5594
Locus tag
CK820_G0039535
See related
Ensembl:ENSPTRG00000005014
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs

Genomic context

See SP1 in Genome Data Viewer
Location:
chromosome: 12
Exon count:
7
Annotation release Status Assembly Chr Location
105 current Clint_PTRv2 (GCF_002880755.1) 12 NC_036891.1 (35676760..35715243, complement)
104 previous assembly Pan_tro 3.0 (GCF_000001515.7) 12 NC_006479.4 (36371022..36409501, complement)
103 previous assembly Pan_troglodytes-2.1.4 (GCF_000001515.6) 12 NC_006479.3 (35839306..35878058, complement)

Chromosome 12 - NC_036891.1Genomic Context describing neighboring genes Neighboring gene proline rich 13 Neighboring gene anti-Mullerian hormone receptor type 2 Neighboring gene Sp7 transcription factor Neighboring gene aladin WD repeat nucleoporin

Genomic regions, transcripts, and products

Pathways from BioSystems

  • Adipogenesis, organism-specific biosystem (from WikiPathways)
    Adipogenesis, organism-specific biosystemThe different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compo...
  • Androgen receptor signaling pathway, organism-specific biosystem (from WikiPathways)
    Androgen receptor signaling pathway, organism-specific biosystemAndrogens, mainly testosterone and 5alpha-dihydrotestosterone (DHT) play significant role in the growth and development of the male reproductive organs. These steroid hormones bring about their biolo...
  • Breast cancer, organism-specific biosystem (from KEGG)
    Breast cancer, organism-specific biosystemBreast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gla...
  • Breast cancer, conserved biosystem (from KEGG)
    Breast cancer, conserved biosystemBreast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gla...
  • Choline metabolism in cancer, organism-specific biosystem (from KEGG)
    Choline metabolism in cancer, organism-specific biosystemAbnormal choline metabolism is emerging as a metabolic hallmark that is associated with oncogenesis and tumour progression. Following transformation, oncogenic signalling via pathways such as the RAS...
  • Choline metabolism in cancer, conserved biosystem (from KEGG)
    Choline metabolism in cancer, conserved biosystemAbnormal choline metabolism is emerging as a metabolic hallmark that is associated with oncogenesis and tumour progression. Following transformation, oncogenic signalling via pathways such as the RAS...
  • EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
  • Endocrine resistance, organism-specific biosystem (from KEGG)
    Endocrine resistance, organism-specific biosystemEndocrine therapy is a key treatment strategy to control or eradicate hormone-responsive breast cancer. The most commonly used endocrine therapy agents are selective estrogen receptor modulators (SER...
  • Endocrine resistance, conserved biosystem (from KEGG)
    Endocrine resistance, conserved biosystemEndocrine therapy is a key treatment strategy to control or eradicate hormone-responsive breast cancer. The most commonly used endocrine therapy agents are selective estrogen receptor modulators (SER...
  • Estrogen signaling pathway, organism-specific biosystem (from KEGG)
    Estrogen signaling pathway, organism-specific biosystemEstrogens are steroid hormones that regulate a plethora of physiological processes in mammals, including reproduction, cardiovascular protection, bone integrity, cellular homeostasis, and behavior. E...
  • Estrogen signaling pathway, conserved biosystem (from KEGG)
    Estrogen signaling pathway, conserved biosystemEstrogens are steroid hormones that regulate a plethora of physiological processes in mammals, including reproduction, cardiovascular protection, bone integrity, cellular homeostasis, and behavior. E...
  • Huntington's disease, organism-specific biosystem (from KEGG)
    Huntington's disease, organism-specific biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
  • Huntington's disease, conserved biosystem (from KEGG)
    Huntington's disease, conserved biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
  • Mitophagy - animal, organism-specific biosystem (from KEGG)
    Mitophagy - animal, organism-specific biosystemMitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process calle...
  • Mitophagy - animal, conserved biosystem (from KEGG)
    Mitophagy - animal, conserved biosystemMitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process calle...
  • TGF-beta signaling pathway, organism-specific biosystem (from KEGG)
    TGF-beta signaling pathway, organism-specific biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
  • TGF-beta signaling pathway, conserved biosystem (from KEGG)
    TGF-beta signaling pathway, conserved biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
  • Transcriptional misregulation in cancer, organism-specific biosystem (from KEGG)
    Transcriptional misregulation in cancer, organism-specific biosystem
    Transcriptional misregulation in cancer
  • Transcriptional misregulation in cancer, conserved biosystem (from KEGG)
    Transcriptional misregulation in cancer, conserved biosystem
    Transcriptional misregulation in cancer

General gene information

Markers

Homology

NCBI Reference Sequences (RefSeq)

RefSeqs of Annotated Genomes: Pan troglodytes Annotation Release 105 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Clint_PTRv2 Primary Assembly

Genomic

  1. NC_036891.1 Reference Clint_PTRv2 Primary Assembly

    Range
    35676760..35715243 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_016923339.2XP_016778828.1  transcription factor Sp1 isoform X3

    Conserved Domains (4) summary
    COG5048
    Location:594665
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:581603
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:639661
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:625648
    zf-H2C2_2; Zinc-finger double domain
  2. XM_003313665.4XP_003313713.1  transcription factor Sp1 isoform X1

    See identical proteins and their annotated locations for XP_003313713.1

    UniProtKB/TrEMBL
    H2Q623
    Related
    ENSPTRP00000008536.4
    Conserved Domains (3) summary
    sd00017
    Location:629651
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:687709
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:673696
    zf-H2C2_2; Zinc-finger double domain
  3. XM_009425320.3XP_009423595.1  transcription factor Sp1 isoform X2

    See identical proteins and their annotated locations for XP_009423595.1

    Related
    ENSPTRP00000062169.1
    Conserved Domains (3) summary
    sd00017
    Location:622644
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:680702
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:666689
    zf-H2C2_2; Zinc-finger double domain
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