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DRD2 dopamine receptor D2 [ Pan troglodytes (chimpanzee) ]

Gene ID: 451553, updated on 5-Oct-2018

Summary

Official Symbol
DRD2provided by VGNC
Official Full Name
dopamine receptor D2provided by VGNC
Primary source
VGNC:VGNC:3283
Locus tag
CK820_G0034347
See related
Ensembl:ENSPTRG00000004295
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs

Genomic context

See DRD2 in Genome Data Viewer
Location:
chromosome: 11
Exon count:
9
Annotation release Status Assembly Chr Location
105 current Clint_PTRv2 (GCF_002880755.1) 11 NC_036890.1 (109208917..109274493, complement)
103 previous assembly Pan_troglodytes-2.1.4 (GCF_000001515.6) 11 NC_006478.3 (111318078..111384547, complement)

Chromosome 11 - NC_036890.1Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 12 Neighboring gene ankyrin repeat and kinase domain containing 1 Neighboring gene transmembrane serine protease 5 Neighboring gene peptide chain release factor 1-like, mitochondrial pseudogene Neighboring gene 40S ribosomal protein S29 pseudogene Neighboring gene zw10 kinetochore protein

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific RNA-sequencing for ten non-human primate species
  • Description: Total RNA sequencing of fifteen different tissues for ten non-human primates
  • BioProject: PRJNA271912
  • Publication: PMID 25392405
  • Analysis date: Tue Apr 3 07:13:10 2018

Pathways from BioSystems

  • Alcoholism, organism-specific biosystem (from KEGG)
    Alcoholism, organism-specific biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
  • Alcoholism, conserved biosystem (from KEGG)
    Alcoholism, conserved biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
  • Cocaine addiction, organism-specific biosystem (from KEGG)
    Cocaine addiction, organism-specific biosystemDrug addiction is a chronic, relapsing disorder in which compulsive drug-seeking and drug-taking behavior persists despite serious negative consequences.There is strong evidence that the dopaminergic...
  • Cocaine addiction, conserved biosystem (from KEGG)
    Cocaine addiction, conserved biosystemDrug addiction is a chronic, relapsing disorder in which compulsive drug-seeking and drug-taking behavior persists despite serious negative consequences.There is strong evidence that the dopaminergic...
  • Dopaminergic synapse, organism-specific biosystem (from KEGG)
    Dopaminergic synapse, organism-specific biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
  • Dopaminergic synapse, conserved biosystem (from KEGG)
    Dopaminergic synapse, conserved biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
  • Gap junction, organism-specific biosystem (from KEGG)
    Gap junction, organism-specific biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
  • Gap junction, conserved biosystem (from KEGG)
    Gap junction, conserved biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
  • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, organism-specific biosystem
    Neuroactive ligand-receptor interaction
  • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, conserved biosystem
    Neuroactive ligand-receptor interaction
  • Parkinson's disease, organism-specific biosystem (from KEGG)
    Parkinson's disease, organism-specific biosystemParkinson's disease (PD) is a progressive neurodegenerative movement disorder that results primarily from the death of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc). Mutations...
  • Rap1 signaling pathway, organism-specific biosystem (from KEGG)
    Rap1 signaling pathway, organism-specific biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
  • Rap1 signaling pathway, conserved biosystem (from KEGG)
    Rap1 signaling pathway, conserved biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
  • cAMP signaling pathway, organism-specific biosystem (from KEGG)
    cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
  • cAMP signaling pathway, conserved biosystem (from KEGG)
    cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...

General gene information

Markers

Homology

General protein information

Preferred Names
D(2) dopamine receptor
Names
D2 dopamine receptor
dopamine D2 receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033928.1NP_001029100.1  D(2) dopamine receptor

    See identical proteins and their annotated locations for NP_001029100.1

    Status: PROVISIONAL

    Source sequence(s)
    AY665279
    UniProtKB/Swiss-Prot
    P60026
    Related
    ENSPTRP00000069210.1, ENSPTRT00000104721.1
    Conserved Domains (2) summary
    pfam00001
    Location:51426
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:49233
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Pan troglodytes Annotation Release 105 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Clint_PTRv2 Primary Assembly

Genomic

  1. NC_036890.1 Reference Clint_PTRv2 Primary Assembly

    Range
    109208917..109274493 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_016919830.1XP_016775319.1  D(2) dopamine receptor isoform X1

    UniProtKB/Swiss-Prot
    P60026
    Conserved Domains (1) summary
    cd15309
    Location:35437
    7tmA_D2_dopamine_R; D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. XM_016919832.1XP_016775321.1  D(2) dopamine receptor isoform X2

    Related
    ENSPTRP00000088340.1, ENSPTRT00000111377.1
    Conserved Domains (1) summary
    cd15309
    Location:35408
    7tmA_D2_dopamine_R; D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. XM_016919831.2XP_016775320.1  D(2) dopamine receptor isoform X1

    UniProtKB/Swiss-Prot
    P60026
    Conserved Domains (1) summary
    cd15309
    Location:35437
    7tmA_D2_dopamine_R; D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
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