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MT-CO2 mitochondrially encoded cytochrome c oxidase II [ Homo sapiens (human) ]

Gene ID: 4513, updated on 4-Dec-2022

Summary

Official Symbol
MT-CO2provided by HGNC
Official Full Name
mitochondrially encoded cytochrome c oxidase IIprovided by HGNC
Primary source
HGNC:HGNC:7421
See related
MIM:516040; AllianceGenome:HGNC:7421
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
COII; MTCO2; COX2
Summary
Contributes to cytochrome-c oxidase activity. Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen and positive regulation of vasoconstriction. Located in mitochondrial inner membrane. Part of respiratory chain complex IV. Biomarker of Huntington's disease and stomach cancer. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See MT-CO2 in Genome Data Viewer
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) MT (non-nuclear) NC_012920.1 (7586..8269)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) MT (non-nuclear) NC_012920.1 (7586..8269)

Chromosome MT - NC_012920.1Genomic Context describing neighboring genes Neighboring gene tRNA-Ser Neighboring gene tRNA-Asp Neighboring gene tRNA-Lys Neighboring gene ATP synthase F0 subunit 8 Neighboring gene ATP synthase F0 subunit 6

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Tat-induced mitochondrial membrane permeabilization is associated with inhibition of cytochrome c oxidase (COX) activity by Tat in disrupted mitochondria from human samples PubMed
capsid gag The interaction of HIV-1 CA with human cellular cytochrome c oxidase II mitochondrial protein (MT-CO2) is identified by yeast two-hybrid screen PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

  • Homologs of the COX2 gene: The COX2 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, A.thaliana, rice, and frog.

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables copper ion binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to cytochrome-c oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to cytochrome-c oxidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables cytochrome-c oxidase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
cytochrome c oxidase subunit II
YP_003024029.1
  • cytochrome c oxidase II

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_012920.1 Reference assembly

    Range
    7586..8269
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_003024029.1 cytochrome c oxidase subunit II (mitochondrion) [Homo sapiens]

    See identical proteins and their annotated locations for YP_003024029.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P00403, Q37526
    UniProtKB/TrEMBL
    A0A1X7RBF7, U5Z487
    Related
    ENSP00000354876.1
    Conserved Domains (1) summary
    MTH00098
    Location:1227
    COX2; cytochrome c oxidase subunit II; Validated