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MT-CO2 mitochondrially encoded cytochrome c oxidase II [ Homo sapiens (human) ]

Gene ID: 4513, updated on 25-Jan-2022

Summary

Official Symbol
MT-CO2provided by HGNC
Official Full Name
mitochondrially encoded cytochrome c oxidase IIprovided by HGNC
Primary source
HGNC:HGNC:7421
See related
MIM:516040; AllianceGenome:HGNC:7421
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
COII; MTCO2; COX2
Summary
Contributes to cytochrome-c oxidase activity. Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen and positive regulation of vasoconstriction. Located in mitochondrial inner membrane. Part of respiratory chain complex IV. Biomarker of Huntington's disease and stomach cancer. [provided by Alliance of Genome Resources, Nov 2021]
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Genomic context

See MT-CO2 in Genome Data Viewer
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) MT (non-nuclear) NC_012920.1 (7586..8269)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) MT (non-nuclear) NC_012920.1 (7586..8269)

Chromosome MT - NC_012920.1Genomic Context describing neighboring genes Neighboring gene tRNA Neighboring gene tRNA Neighboring gene tRNA Neighboring gene ATP synthase F0 subunit 8 Neighboring gene ATP synthase F0 subunit 6

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Tat-induced mitochondrial membrane permeabilization is associated with inhibition of cytochrome c oxidase (COX) activity by Tat in disrupted mitochondria from human samples PubMed
capsid gag The interaction of HIV-1 CA with human cellular cytochrome c oxidase II mitochondrial protein (MT-CO2) is identified by yeast two-hybrid screen PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

  • Homologs of the COX2 gene: The COX2 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, A.thaliana, rice, and frog.
  • Orthologs

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables copper ion binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to cytochrome-c oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to cytochrome-c oxidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables cytochrome-c oxidase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in ATP synthesis coupled electron transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in lactation IEA
Inferred from Electronic Annotation
more info
 
involved_in mitochondrial electron transport, cytochrome c to oxygen ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in mitochondrial electron transport, cytochrome c to oxygen NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of ATP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of hydrogen peroxide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of necrotic cell death IEA
Inferred from Electronic Annotation
more info
 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in response to cold IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cytochrome c oxidase subunit II
YP_003024029.1
  • cytochrome c oxidase II

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_012920.1 Reference assembly

    Range
    7586..8269
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_003024029.1 cytochrome c oxidase subunit II (mitochondrion) [Homo sapiens]

    See identical proteins and their annotated locations for YP_003024029.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P00403
    UniProtKB/TrEMBL
    U5Z487
    Related
    ENSP00000354876.1
    Conserved Domains (1) summary
    MTH00098
    Location:1227
    COX2; cytochrome c oxidase subunit II; Validated
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