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MT-CO2 mitochondrially encoded cytochrome c oxidase II [ Homo sapiens (human) ]

Gene ID: 4513, updated on 4-Oct-2020

Summary

Official Symbol
MT-CO2provided by HGNC
Official Full Name
mitochondrially encoded cytochrome c oxidase IIprovided by HGNC
Primary source
HGNC:HGNC:7421
See related
MIM:516040
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
COII; MTCO2; COX2

Genomic context

See MT-CO2 in Genome Data Viewer
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) MT (non-nuclear) NC_012920.1 (7586..8269)
105 previous assembly GRCh37.p13 (GCF_000001405.25) MT (non-nuclear) NC_012920.1 (7586..8269)

Chromosome MT - NC_012920.1Genomic Context describing neighboring genes Neighboring gene tRNA Neighboring gene tRNA Neighboring gene tRNA Neighboring gene ATP synthase F0 subunit 8 Neighboring gene ATP synthase F0 subunit 6

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Tat-induced mitochondrial membrane permeabilization is associated with inhibition of cytochrome c oxidase (COX) activity by Tat in disrupted mitochondria from human samples PubMed
capsid gag The interaction of HIV-1 CA with human cellular cytochrome c oxidase II mitochondrial protein (MT-CO2) is identified by yeast two-hybrid screen PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

  • Homologs of the COX2 gene: The COX2 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, A.thaliana, rice, and frog.
  • Orthologs

Gene Ontology Provided by GOA

Function Evidence Code Pubs
copper ion binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to cytochrome-c oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to cytochrome-c oxidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytochrome-c oxidase activity NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
ATP synthesis coupled electron transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lactation IEA
Inferred from Electronic Annotation
more info
 
mitochondrial electron transport, cytochrome c to oxygen NAS
Non-traceable Author Statement
more info
PubMed 
mitochondrial electron transport, cytochrome c to oxygen TAS
Traceable Author Statement
more info
 
positive regulation of ATP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of hydrogen peroxide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of necrotic cell death IEA
Inferred from Electronic Annotation
more info
 
proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
response to cold IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
respiratory chain complex IV IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cytochrome c oxidase subunit II
YP_003024029.1
  • cytochrome c oxidase II

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_012920.1 Reference assembly

    Range
    7586..8269
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_003024029.1 cytochrome c oxidase subunit II (mitochondrion) [Homo sapiens]

    See identical proteins and their annotated locations for YP_003024029.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P00403
    UniProtKB/TrEMBL
    U5Z487
    Related
    ENSP00000354876.1
    Conserved Domains (1) summary
    MTH00098
    Location:1227
    COX2; cytochrome c oxidase subunit II; Validated
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