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HBB hemoglobin subunit beta [ Pan troglodytes (chimpanzee) ]

Gene ID: 450978, updated on 29-Mar-2024

Summary

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Official Symbol
HBBprovided by VGNC
Official Full Name
hemoglobin subunit betaprovided by VGNC
Primary source
VGNC:VGNC:3255
Locus tag
CK820_G0005984
See related
Ensembl:ENSPTRG00000040047
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Also known as
GLNA1
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Genomic context

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Location:
chromosome: 11
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 9 NC_072407.2 (9357035..9358653, complement)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 11 NC_072409.1 (9248609..9250211, complement)

Chromosome 9 - NC_072407.2Genomic Context describing neighboring genes Neighboring gene olfactory receptor 51I2-like Neighboring gene olfactory receptor family 51 subfamily V member 1 Neighboring gene hemoglobin subunit delta Neighboring gene uncharacterized LOC748584

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The untranslated regions of beta-globin mRNA evolve at a functional rate in higher primates. Martin SL, et al. Cell, 1981 Sep. PMID 7285116
  2. Evolution of the primate beta-globin gene region. High rate of variation in CpG dinucleotides and in short repeated sequences between man and chimpanzee. Savatier P, et al. J Mol Biol, 1985 Mar 5. PMID 3999143
  3. Analysis of the beta-globin gene in DNA of suspected thalassemic great apes. Vuch J, et al. Genet Mol Res, 2013 May 21. PMID 23765979
  4. The action of falciparum malaria on the human and chimpanzee genomes compared: absence of evidence for a genomic signature of malaria at HBB and G6PD in three subspecies of chimpanzee. MacFie TS, et al. Infect Genet Evol, 2009 Dec. PMID 19631293
  5. The characterization of the tryptic peptides from the hemoglobin of the chimpanzee (Pan troglodytes). Rifkin D, et al. Biochim Biophys Acta, 1965 Jul 8. PMID 5855051

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pan troglodytes and Pongo pygmaeus were screened for mutations in the beta-globin gene (exons 1, 2, and 3) for suspected thalassemia.
    Title: Analysis of the beta-globin gene in DNA of suspected thalassemic great apes.
  2. We found no evidence of the major deleterious mutations at HBB in chimpanzees that confer resistance to malaria caused by Plasmodium falciparum nor evidence of long-term balancing selection at these loci.
    Title: The action of falciparum malaria on the human and chimpanzee genomes compared: absence of evidence for a genomic signature of malaria at HBB and G6PD in three subspecies of chimpanzee.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables haptoglobin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables heme binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables hemoglobin alpha binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables organic acid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables oxygen binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables oxygen carrier activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables peroxidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in hydrogen peroxide catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in oxygen transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in blood microparticle IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of haptoglobin-hemoglobin complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of hemoglobin complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
hemoglobin subunit beta
Names
beta globin
globin A1
hemoglobin beta chain
hemoglobin, beta

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072407.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    9357035..9358653 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_508242.5 → XP_508242.1  hemoglobin subunit beta

    See identical proteins and their annotated locations for XP_508242.1

    UniProtKB/Swiss-Prot
    P68873, Q28799
    UniProtKB/TrEMBL
    A0A1K0H3L7, A0A2J8P6S4, A0A663DJ46
    Related
    ENSPTRP00000005700.3
    Conserved Domains (1) summary
    cd08925
    Location:8 → 146
    Hb-beta-like; Hemoglobin beta, gamma, delta, epsilon, and related Hb subunits
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P68873.2 GenPept UniProtKB/Swiss-Prot:P68873

Gene LinkOut

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Molecular Biology Databases
Research Materials
Miscellaneous