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MT-ATP8 mitochondrially encoded ATP synthase 8 [ Homo sapiens (human) ]

Gene ID: 4509, updated on 7-Apr-2025

Summary

Official Symbol
MT-ATP8provided by HGNC
Official Full Name
mitochondrially encoded ATP synthase 8provided by HGNC
Primary source
HGNC:HGNC:7415
See related
MIM:516070; AllianceGenome:HGNC:7415
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATPase8; MTATP8; ATP8
Summary
Contributes to proton-transporting ATP synthase activity, rotational mechanism. Involved in proton motive force-driven mitochondrial ATP synthesis. Located in mitochondrion. Part of proton-transporting ATP synthase complex. Implicated in multiple sclerosis and urinary bladder cancer. [provided by Alliance of Genome Resources, Apr 2025]
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Genomic context

See MT-ATP8 in Genome Data Viewer
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) MT (non-nuclear) NC_012920.1 (8366..8572)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) MT (non-nuclear) NC_012920.1 (8366..8572)

Chromosome MT - NC_012920.1Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit II Neighboring gene tRNA-Lys Neighboring gene ATP synthase F0 subunit 6 Neighboring gene cytochrome c oxidase subunit III Neighboring gene tRNA-Gly

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables proton transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to proton-transporting ATP synthase activity, rotational mechanism IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in ATP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in proton motive force-driven ATP synthesis IEA
Inferred from Electronic Annotation
more info
 
involved_in proton motive force-driven ATP synthesis NAS
Non-traceable Author Statement
more info
PubMed 
involved_in proton motive force-driven mitochondrial ATP synthesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HTP PubMed 
located_in mitochondrion IC
Inferred by Curator
more info
PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
part_of proton-transporting ATP synthase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of proton-transporting ATP synthase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of proton-transporting ATP synthase complex IEA
Inferred from Electronic Annotation
more info
 
part_of proton-transporting ATP synthase complex NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
ATP synthase F0 subunit 8
YP_003024030.1
  • ATP synthase 8; ATPase subunit 8

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_012920.1 Reference assembly

    Range
    8366..8572
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_003024030.1 ATP synthase F0 subunit 8 (mitochondrion) [Homo sapiens]

    See identical proteins and their annotated locations for YP_003024030.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P03928, Q34771
    UniProtKB/TrEMBL
    A0A059QM53, A0A1X7RCP4, U5YV54
    Related
    ENSP00000355265.1
    Conserved Domains (1) summary
    MTH00102
    Location:167
    ATP8; ATP synthase F0 subunit 8; Validated