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MT-ATP6 mitochondrially encoded ATP synthase 6 [ Homo sapiens (human) ]

Gene ID: 4508, updated on 28-May-2022

Summary

Official Symbol
MT-ATP6provided by HGNC
Official Full Name
mitochondrially encoded ATP synthase 6provided by HGNC
Primary source
HGNC:HGNC:7414
See related
MIM:516060; AllianceGenome:HGNC:7414
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATPase6; MTATP6; ATP6
Summary
Contributes to proton-transporting ATP synthase activity, rotational mechanism. Involved in mitochondrial ATP synthesis coupled proton transport. Part of mitochondrial proton-transporting ATP synthase complex. Implicated in Leber hereditary optic neuropathy; NARP syndrome; Parkinson's disease; multiple sclerosis; and systemic lupus erythematosus. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See MT-ATP6 in Genome Data Viewer
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) MT (non-nuclear) NC_012920.1 (8527..9207)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) MT (non-nuclear) NC_012920.1 (8527..9207)

Chromosome MT - NC_012920.1Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit II Neighboring gene tRNA-Lys Neighboring gene ATP synthase F0 subunit 8 Neighboring gene cytochrome c oxidase subunit III Neighboring gene tRNA-Gly

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to proton-transporting ATP synthase activity, rotational mechanism IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in aging IEA
Inferred from Electronic Annotation
more info
 
involved_in proton motive force-driven ATP synthesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in proton motive force-driven ATP synthesis IC
Inferred by Curator
more info
PubMed 
involved_in proton motive force-driven mitochondrial ATP synthesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in response to hyperoxia IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ATP synthase F0 subunit 6
YP_003024031.1
  • ATP synthase 6; ATPase subunit 6

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_012920.1 Reference assembly

    Range
    8527..9207
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_003024031.1 ATP synthase F0 subunit 6 (mitochondrion) [Homo sapiens]

    See identical proteins and their annotated locations for YP_003024031.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P00846
    UniProtKB/TrEMBL
    Q0ZFE3
    Related
    ENSP00000354632.2
    Conserved Domains (1) summary
    MTH00101
    Location:1226
    ATP6; ATP synthase F0 subunit 6; Validated