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Vha68-2 Vacuolar H[+] ATPase 68 kDa subunit 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 45012, updated on 6-Aug-2017
Official Symbol
Vha68-2provided by FlyBase
Official Full Name
Vacuolar H[+] ATPase 68 kDa subunit 2provided by FlyBase
Primary source
FLYBASE:FBgn0263598
Locus tag
Dmel_CG3762
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster (old-lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
A subunit; ATP6V1A; CG3762; Dmel\CG3762; l(2)01510; l(2)s4214; MENE-R6; RE30552p; vha67-2; Vha68; vha68-2; Vha68.2
Location:
34A3-34A3
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.13 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (12974322..12978607)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (12974322..12978607)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene CG16800 gene product from transcript CG16800-RB Neighboring gene Vacuolar H[+] ATPase 68kD subunit 3 Neighboring gene CG12404 gene product from transcript CG12404-RA

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
proton-transporting ATPase activity, rotational mechanism IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to proton-transporting ATPase activity, rotational mechanism IC
Inferred by Curator
more info
PubMed 
Process Evidence Code Pubs
ATP hydrolysis coupled proton transport IC
Inferred by Curator
more info
PubMed 
ATP hydrolysis coupled proton transport IEA
Inferred from Electronic Annotation
more info
 
ATP metabolic process IEA
Inferred from Electronic Annotation
more info
 
endosomal lumen acidification IMP
Inferred from Mutant Phenotype
more info
PubMed 
endosomal transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
imaginal disc growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
lumen formation, open tracheal system IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane proton-transporting V-type ATPase complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
vacuolar proton-transporting V-type ATPase, V1 domain ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Preferred Names
CG3762 gene product from transcript CG3762-RF
Names
CG3762-PA
CG3762-PB
CG3762-PC
CG3762-PD
CG3762-PE
CG3762-PF
V-ATPase 69 kDa subunit 2
Vha68-2-PA
Vha68-2-PB
Vha68-2-PC
Vha68-2-PD
Vha68-2-PE
Vha68-2-PF
vacuolar ATPase
vacuolar H[+] ATPase 68 kDa subunit 2
vacuolar H[+] ATPase subunit 68-2
NP_001246015.1
NP_001260424.1
NP_001260425.1
NP_652004.2
NP_723775.1
NP_723776.1

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    12974322..12978607
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273496.1NP_001260425.1  vacuolar H[+] ATPase 68 kDa subunit 2, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260425.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q27331
    UniProtKB/TrEMBL
    A4V0N4
    Related
    FBpp0307597, FBtr0336614
    Conserved Domains (4) summary
    cd01134
    Location:83454
    V_A-ATPase_A; V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi ...
    TIGR01042
    Location:16606
    V-ATPase_V1_A; V-type (H+)-ATPase V1, A subunit
    pfam00306
    Location:472614
    ATP-synt_ab_C; ATP synthase alpha/beta chain, C terminal domain
    pfam02874
    Location:1981
    ATP-synt_ab_N; ATP synthase alpha/beta family, beta-barrel domain
  2. NM_143747.3NP_652004.2  vacuolar H[+] ATPase 68 kDa subunit 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_652004.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q27331
    UniProtKB/TrEMBL
    A4V0N4
    Related
    FBpp0079999, FBtr0080418
    Conserved Domains (4) summary
    cd01134
    Location:83454
    V_A-ATPase_A; V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi ...
    TIGR01042
    Location:16606
    V-ATPase_V1_A; V-type (H+)-ATPase V1, A subunit
    pfam00306
    Location:472614
    ATP-synt_ab_C; ATP synthase alpha/beta chain, C terminal domain
    pfam02874
    Location:1981
    ATP-synt_ab_N; ATP synthase alpha/beta family, beta-barrel domain
  3. NM_165021.2NP_723775.1  vacuolar H[+] ATPase 68 kDa subunit 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723775.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q27331
    UniProtKB/TrEMBL
    A4V0N4
    Related
    FBpp0080000, FBtr0080419
    Conserved Domains (4) summary
    cd01134
    Location:83454
    V_A-ATPase_A; V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi ...
    TIGR01042
    Location:16606
    V-ATPase_V1_A; V-type (H+)-ATPase V1, A subunit
    pfam00306
    Location:472614
    ATP-synt_ab_C; ATP synthase alpha/beta chain, C terminal domain
    pfam02874
    Location:1981
    ATP-synt_ab_N; ATP synthase alpha/beta family, beta-barrel domain
  4. NM_165022.2NP_723776.1  vacuolar H[+] ATPase 68 kDa subunit 2, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723776.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q27331
    UniProtKB/TrEMBL
    A4V0N4
    Related
    FBpp0080001, FBtr0080420
    Conserved Domains (4) summary
    cd01134
    Location:83454
    V_A-ATPase_A; V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi ...
    TIGR01042
    Location:16606
    V-ATPase_V1_A; V-type (H+)-ATPase V1, A subunit
    pfam00306
    Location:472614
    ATP-synt_ab_C; ATP synthase alpha/beta chain, C terminal domain
    pfam02874
    Location:1981
    ATP-synt_ab_N; ATP synthase alpha/beta family, beta-barrel domain
  5. NM_001259086.2NP_001246015.1  vacuolar H[+] ATPase 68 kDa subunit 2, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246015.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q27331
    UniProtKB/TrEMBL
    A4V0N4
    Related
    FBpp0294002, FBtr0305551
    Conserved Domains (4) summary
    cd01134
    Location:83454
    V_A-ATPase_A; V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi ...
    TIGR01042
    Location:16606
    V-ATPase_V1_A; V-type (H+)-ATPase V1, A subunit
    pfam00306
    Location:472614
    ATP-synt_ab_C; ATP synthase alpha/beta chain, C terminal domain
    pfam02874
    Location:1981
    ATP-synt_ab_N; ATP synthase alpha/beta family, beta-barrel domain
  6. NM_001273495.1NP_001260424.1  vacuolar H[+] ATPase 68 kDa subunit 2, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260424.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q27331
    UniProtKB/TrEMBL
    A4V0N4
    Related
    FBpp0307596, FBtr0336613
    Conserved Domains (4) summary
    cd01134
    Location:83454
    V_A-ATPase_A; V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi ...
    TIGR01042
    Location:16606
    V-ATPase_V1_A; V-type (H+)-ATPase V1, A subunit
    pfam00306
    Location:472614
    ATP-synt_ab_C; ATP synthase alpha/beta chain, C terminal domain
    pfam02874
    Location:1981
    ATP-synt_ab_N; ATP synthase alpha/beta family, beta-barrel domain
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