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amt aminomethyltransferase [ Danio rerio (zebrafish) ]

Gene ID: 450000, updated on 19-May-2025
Official Symbol
amtprovided by ZNC
Official Full Name
aminomethyltransferaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-041010-114
See related
Ensembl:ENSDARG00000010862 AllianceGenome:ZFIN:ZDB-GENE-041010-114
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fc31f04; wu:fc31f04; wu:fd44b12; wu:fd54h12; zgc:103483; zgc:109741
Summary
Predicted to enable aminomethyltransferase activity; methyltransferase activity; and transaminase activity. Predicted to act upstream of or within glycine catabolic process and methylation. Predicted to be active in mitochondrion. Is expressed in several structures, including alar plate midbrain region; eye; optic tectum; pleuroperitoneal region; and yolk syncytial layer. Human ortholog(s) of this gene implicated in glycine encephalopathy and glycine encephalopathy 2. Orthologous to human AMT (aminomethyltransferase). [provided by Alliance of Genome Resources, May 2025]
Orthologs
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See amt in Genome Data Viewer
Location:
chromosome: 8
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 8 NC_133183.1 (28296360..28309409)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 8 NC_007119.7 (26396575..26408839)

Chromosome 8 - NC_133183.1Genomic Context describing neighboring genes Neighboring gene si:dkey-20d21.12 Neighboring gene hyaluronidase 3 Neighboring gene N-alpha-acetyltransferase 80, NatH catalytic subunit Neighboring gene interferon-related developmental regulator 2 Neighboring gene zgc:136971

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Markers

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables aminomethyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transaminase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within glycine catabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
aminomethyltransferase, mitochondrial
NP_001006021.1
XP_073765460.1
XP_073765461.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006021.1NP_001006021.1  aminomethyltransferase, mitochondrial

    See identical proteins and their annotated locations for NP_001006021.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083400
    UniProtKB/TrEMBL
    Q5XJA4
    Related
    ENSDARP00000081585.3, ENSDART00000087151.5
    Conserved Domains (3) summary
    PLN02319
    Location:2407
    PLN02319; aminomethyltransferase
    pfam01571
    Location:46298
    GCV_T; Aminomethyltransferase folate-binding domain
    pfam08669
    Location:307399
    GCV_T_C; Glycine cleavage T-protein C-terminal barrel domain

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133183.1 Reference GRCz12tu Primary Assembly

    Range
    28296360..28309409
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_073909360.1XP_073765461.1  aminomethyltransferase, mitochondrial isoform X2

  2. XM_073909359.1XP_073765460.1  aminomethyltransferase, mitochondrial isoform X1