mgst1.1 microsomal glutathione S-transferase 1.1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mgst1.1provided by ZNC
Official Full Name: microsomal glutathione S-transferase 1.1provided by ZNC
Primary source: ZFIN:ZDB-GENE-041010-30
See related: Ensembl:ENSDARG00000032618 AllianceGenome:ZFIN:ZDB-GENE-041010-30
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: mgst1; zgc:101898
Summary: Predicted to enable glutathione transferase activity. Acts upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in mitochondrion. Is expressed in brain; gill; hematopoietic system; liver; and pleuroperitoneal region. Orthologous to human MGST1 (microsomal glutathione S-transferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (12715590..12718352, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (12716741..12719503, complement)
103	previous assembly	Zv9 (GCF_000002035.4)	4	NC_007115.5 (11780119..11782876, complement)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

high expression of MGST1 was detected in regions of active hematopoiesis and co-expressed with markers for hematopoietic stem cells. Further, morpholino-mediated knock-down of MGST1 led to a significant reduction of differentiated hematopoietic cells both from the myeloid and the lymphoid lineages.
Title: MGST1, a GSH transferase/peroxidase essential for development and hematopoietic stem cell differentiation.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables glutathione transferase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables glutathione transferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hemopoiesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: microsomal glutathione S-transferase 1.1

Names: Mgst1b; microsomal glutathione S-transferase 1

NP_001005957.1

EC 2.5.1.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.