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tars threonyl-tRNA synthetase [ Danio rerio (zebrafish) ]

Gene ID: 449661, updated on 12-Aug-2018

Summary

Official Symbol
tarsprovided by ZNC
Official Full Name
threonyl-tRNA synthetaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-041010-218
See related
Ensembl:ENSDARG00000013250 Vega:OTTDARG00000019036
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Danio
Also known as
ThrRS; zgc:92586; wu:fb07c05; wu:fb39c12
Orthologs

Genomic context

See tars in Genome Data Viewer
Location:
chromosome: 5
Exon count:
19
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (44346675..44371177)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (43746589..43771020)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene si:dkey-84j12.1 Neighboring gene si:ch73-337l15.2 Neighboring gene uncharacterized LOC103911103 Neighboring gene growth arrest-specific 1a

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
threonine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
threonine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
branching involved in blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
 
tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
 
threonyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
threonyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
 
vasculature development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
threonine--tRNA ligase, cytoplasmic
Names
threonine--tRNA ligase
NP_001005932.1
NP_001116258.1
XP_021331773.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005932.2NP_001005932.1  threonine--tRNA ligase, cytoplasmic isoform 2

    See identical proteins and their annotated locations for NP_001005932.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083525
    UniProtKB/TrEMBL
    Q5XIZ3
    Conserved Domains (5) summary
    cd01667
    Location:78139
    TGS_ThrRS_N; TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and ...
    PLN02908
    Location:46617
    PLN02908; threonyl-tRNA synthetase
    smart00863
    Location:245292
    tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain
    cd00771
    Location:300519
    ThrRS_core; Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent ...
    cd00860
    Location:519610
    ThrRS_anticodon; ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is ...
  2. NM_001122786.1NP_001116258.1  threonine--tRNA ligase, cytoplasmic isoform 1

    See identical proteins and their annotated locations for NP_001116258.1

    Status: PROVISIONAL

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
    Source sequence(s)
    BC154371
    UniProtKB/TrEMBL
    A8KC60
    Related
    ENSDARP00000036825.6, OTTDARP00000019379, ENSDART00000034523.8, OTTDART00000023278
    Conserved Domains (5) summary
    cd01667
    Location:78139
    TGS_ThrRS_N; TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and ...
    PLN02908
    Location:32711
    PLN02908; threonyl-tRNA synthetase
    smart00863
    Location:245292
    tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain
    cd00771
    Location:316613
    ThrRS_core; Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent ...
    cd00860
    Location:613704
    ThrRS_anticodon; ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    44346675..44371177
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021476098.1XP_021331773.1  threonine--tRNA ligase, cytoplasmic isoform X1

    Conserved Domains (1) summary
    cl28417
    Location:1556
    ThrS; Threonyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394605.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    111915..136632
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395243.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    32874..57305
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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