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ppp2r1bb protein phosphatase 2, regulatory subunit A, beta b [ Danio rerio (zebrafish) ]

Gene ID: 449548, updated on 4-Nov-2022

Summary

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Official Symbol
ppp2r1bbprovided by ZNC
Official Full Name
protein phosphatase 2, regulatory subunit A, beta bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040927-20
See related
Ensembl:ENSDARG00000032430 AllianceGenome:ZFIN:ZDB-GENE-040927-20
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ppp2r1b; zgc:92493; tdsubc_2h3; wu:fa11a11; wu:fb38a08; ik:tdsubc_2h3; xx:tdsubc_2h3
Summary
Predicted to enable protein phosphatase regulator activity. Predicted to be involved in protein dephosphorylation. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytoplasm. Is expressed in female organism. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 36. Orthologous to several human genes including PPP2R1B (protein phosphatase 2 scaffold subunit Abeta). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See ppp2r1bb in Genome Data Viewer
Location:
chromosome: 15
Exon count:
15
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (21744743..21772837)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (21809011..21837105)
103 previous assembly Zv9 (GCF_000002035.4) 15 NC_007126.5 (20706385..20734479)

Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene interleukin 4 induced 1 Neighboring gene NKAP domain containing 1 Neighboring gene salt-inducible kinase 2b Neighboring gene layilin b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The dependence receptor UNC5H2/B triggers apoptosis via PP2A-mediated dephosphorylation of DAP kinase. Guenebeaud C, et al. Mol Cell, 2010 Dec 22. PMID 21172653
  2. Proteomics of early zebrafish embryos. Link V, et al. BMC Dev Biol, 2006 Jan 13. PMID 16412219, Free PMC Article
  3. Hepatic gene expression profiling using GeneChips in zebrafish exposed to 17alpha-methyldihydrotestosterone. Hoffmann JL, et al. Aquat Toxicol, 2008 Apr 28. PMID 18339436
  4. Brain transcriptome analysis of a familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production. Newman M, et al. Mol Brain, 2019 May 3. PMID 31053140, Free PMC Article
  5. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables protein phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
part_of protein phosphatase type 2A complex IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
NP_001005590.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005590.1 → NP_001005590.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

    See identical proteins and their annotated locations for NP_001005590.1

    Status: PROVISIONAL

    Source sequence(s)
    BC081658
    UniProtKB/TrEMBL
    A0A8M1N246, Q642H5
    Related
    ENSDARP00000017693.7, ENSDART00000016860.8
    Conserved Domains (4) summary
    pfam13513
    Location:179 → 227
    HEAT_EZ; HEAT-like repeat
    pfam13646
    Location:207 → 303
    HEAT_2; HEAT repeats
    sd00044
    Location:245 → 269
    HEAT; HEAT repeat [structural motif]
    cl21454
    Location:396 → 454
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007126.7 Reference GRCz11 Primary Assembly

    Range
    21744743..21772837
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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