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hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 [ Danio rerio (zebrafish) ]

Gene ID: 449537, updated on 27-Mar-2024

Summary

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Official Symbol
hsd17b2provided by ZNC
Official Full Name
hydroxysteroid (17-beta) dehydrogenase 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-040928-1
See related
Ensembl:ENSDARG00000045553 AllianceGenome:ZFIN:ZDB-GENE-040928-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable steroid dehydrogenase activity. Is expressed in brain; heart; integument; pleuroperitoneal region; and trunk musculature. Orthologous to human HSD17B2 (hydroxysteroid 17-beta dehydrogenase 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
chromosome: 25
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (35942867..35950740)
105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (35437928..35445713)

Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene LSM14A mRNA processing body assembly factor a Neighboring gene glucose-6-phosphate isomerase a Neighboring gene uncharacterized LOC110438402 Neighboring gene M-phase phosphoprotein 6 Neighboring gene sorting nexin 20

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Functional genome analysis indicates loss of 17beta-hydroxysteroid dehydrogenase type 2 enzyme in the zebrafish. Mindnich R, et al. J Steroid Biochem Mol Biol, 2007 Jan. PMID 17085046
  2. Evolutionary analysis of 11beta-hydroxysteroid dehydrogenase-type 1, -type 2, -type 3 and 17beta-hydroxysteroid dehydrogenase-type 2 in fish. Baker ME. FEBS Lett, 2004 Sep 10. PMID 15358559
  3. Leptin-mediated modulation of steroidogenic gene expression in hypoxic zebrafish embryos: implications for the disruption of sex steroids. Yu RM, et al. Environ Sci Technol, 2012 Aug 21. PMID 22816610
  4. Overexpression and Knockdown of Hypoxia-Inducible Factor 1 Disrupt the Expression of Steroidogenic Enzyme Genes and Early Embryonic Development in Zebrafish. Tan T, et al. Gene Regul Syst Bio, 2017. PMID 28634424, Free PMC Article
  5. Reproductive effects of synthetic progestin norgestrel in zebrafish (Danio rerio). Liang YQ, et al. Chemosphere, 2018 Jan. PMID 28972919

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
NOT enables estradiol 17-beta-dehydrogenase [NAD(P)] activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables estradiol 17-beta-dehydrogenase [NAD(P)] activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables steroid dehydrogenase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
NOT enables testosterone dehydrogenase (NAD+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
estradiol 17-beta-dehydrogenase 2
NP_001035278.1
XP_005163234.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040188.1 → NP_001035278.1  estradiol 17-beta-dehydrogenase 2

    See identical proteins and their annotated locations for NP_001035278.1

    Status: PROVISIONAL

    Source sequence(s)
    DQ364628
    UniProtKB/TrEMBL
    Q1PLL0
    Related
    ENSDARP00000066984.5, ENSDART00000066985.7
    Conserved Domains (2) summary
    pfam00106
    Location:66 → 253
    adh_short; short chain dehydrogenase
    cl21454
    Location:66 → 338
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007136.7 Reference GRCz11 Primary Assembly

    Range
    35942867..35950740
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005163177.4 → XP_005163234.1  estradiol 17-beta-dehydrogenase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BAC5
    Conserved Domains (2) summary
    pfam00106
    Location:82 → 276
    adh_short; short chain dehydrogenase
    cl21454
    Location:82 → 361
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein Strain
Heading Accession and Version

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