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MT1G metallothionein 1G [ Homo sapiens (human) ]

Gene ID: 4495, updated on 9-Jan-2019

Summary

Official Symbol
MT1Gprovided by HGNC
Official Full Name
metallothionein 1Gprovided by HGNC
Primary source
HGNC:HGNC:7399
See related
Ensembl:ENSG00000125144 MIM:156353
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MT1; MT1K
Expression
Biased expression in kidney (RPKM 963.2), thyroid (RPKM 736.8) and 7 other tissues See more

Genomic context

See MT1G in Genome Data Viewer
Location:
16q13
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (56666735..56668065, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (56700653..56701977, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene metallothionein 1F Neighboring gene uncharacterized LOC101927536 Neighboring gene metallothionein 1H Neighboring gene metallothionein 1I, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including Metallothionein, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Copper homeostasis, organism-specific biosystem (from WikiPathways)
    Copper homeostasis, organism-specific biosystemCopper is a redox-active transition metal and an essential trace element for life. It is a catalytic cofactor for numerous enzymes involved in critical biological processes (eg. detoxyfication by oxy...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metallothioneins bind metals, organism-specific biosystem (from REACTOME)
    Metallothioneins bind metals, organism-specific biosystemMetallothioneins are highly conserved, cysteine-rich proteins that bind metals via thiolate bonds (recent general reviews in Capdevila et al. 2012, Blindauer et al. 2014, reviews of mammalian metallo...
  • Mineral absorption, organism-specific biosystem (from KEGG)
    Mineral absorption, organism-specific biosystemMinerals are one of the five fundamental groups of nutrients needed to sustain life. Of the minerals, calcium plays innumerable roles in our bodies, serving as a main component of bone as well as an ...
  • Mineral absorption, conserved biosystem (from KEGG)
    Mineral absorption, conserved biosystemMinerals are one of the five fundamental groups of nutrients needed to sustain life. Of the minerals, calcium plays innumerable roles in our bodies, serving as a main component of bone as well as an ...
  • Response to metal ions, organism-specific biosystem (from REACTOME)
    Response to metal ions, organism-specific biosystemThough metals such as zinc, copper, and iron are required as cofactors for cellular enzymes they can also catalyze damaging metal substitution or unspecific redox reactions if they are not sequestere...
  • Zinc homeostasis, organism-specific biosystem (from WikiPathways)
    Zinc homeostasis, organism-specific biosystemZinc is a transition metal and catalytic cofactor involved in many biological processes such as proliferation, development and differentiation, regulation of DNA synthesis, genomic stability, cell ac...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC12386

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cellular response to cadmium ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to cadmium ion IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to copper ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to copper ion IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to vascular endothelial growth factor stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to zinc ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to zinc ion IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to zinc ion IEP
Inferred from Expression Pattern
more info
PubMed 
cellular zinc ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
detoxification of copper ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
monocyte activation NAS
Non-traceable Author Statement
more info
PubMed 
monocyte differentiation NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of growth IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
metallothionein-1G
Names
MT-1G
MT-1K
MT-IG
metallothionein-1K
metallothionein-IG

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301267.1NP_001288196.1  metallothionein-1G isoform 2

    See identical proteins and their annotated locations for NP_001288196.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The resulting isoform (2) is one aa longer than isoform 1.
    Source sequence(s)
    BC020757, BM817643
    Consensus CDS
    CCDS76873.1
    UniProtKB/Swiss-Prot
    P13640
    Related
    ENSP00000369139.3, ENST00000379811.3
    Conserved Domains (1) summary
    pfam00131
    Location:962
    Metallothio; Metallothionein
  2. NM_005950.2NP_005941.1  metallothionein-1G isoform 1

    See identical proteins and their annotated locations for NP_005941.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).
    Source sequence(s)
    BC020757, BM817643, CD175975
    Consensus CDS
    CCDS10766.1
    UniProtKB/Swiss-Prot
    P13640
    Related
    ENSP00000391397.2, ENST00000444837.6
    Conserved Domains (1) summary
    pfam00131
    Location:561
    Metallothio; Metallothionein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    56666735..56668065 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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