Hsp70Ba Heat shock protein 70 Ba [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Hsp70Baprovided by FlyBase
Official Full Name: Heat shock protein 70 Baprovided by FlyBase
Primary source: FLYBASE:FBgn0013277
Locus tag: Dmel_CG31449
See related: AllianceGenome:FB:FBgn0013277
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG31449; dhsp70; dHsp70; Dm-hsp70; Dmel\CG31449; Hsp 70; hsp-70; Hsp-70; hsp70; Hsp70; HSP70; hsp70 87C; hsp70 Ba; Hsp70(87C); hsp70b; hsp70B; Hsp70B; hsp70ba; hsp70Ba; HSP70cA3
Summary: Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and misfolded protein binding activity. Involved in heat shock-mediated polytene chromosome puffing and response to hypoxia. Predicted to be active in cytosol; nucleus; and plasma membrane. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; systemic lupus erythematosus; toxic shock syndrome; type 2 diabetes mellitus; and urinary tract infection. Orthologous to human HSPA1L (heat shock protein family A (Hsp70) member 1 like); HSPA1B (heat shock protein family A (Hsp70) member 1B); and HSPA6 (heat shock protein family A (Hsp70) member 6). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 87B12-87B12; 3-52 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
Release 6.46	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (12465453..12467776, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (8291175..8293498, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings suggest that the absence of expression of Hsp70Ba increases coefficient of variation of some morphological traits and that HSP70Ba may buffer against environmental perturbations on some quantitative traits.
Title: Environmental stress-dependent effects of deletions encompassing Hsp70Ba on canalization and quantitative trait asymmetry in Drosophila melanogaster.
Life span alteration after irradiation in Drosophila melanogaster strains with mutations of Hsf and Hsps.
Title: Life span alteration after irradiation in Drosophila melanogaster strains with mutations of Hsf and Hsps.
cAMP-response element-binding protein and heat-shock protein 70 additively suppress polyglutamine-mediated toxicity.
Title: cAMP-response element-binding protein and heat-shock protein 70 additively suppress polyglutamine-mediated toxicity in Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables heat shock protein binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables protein folding chaperone	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Process	Evidence Code	Pubs
involved_in chaperone cofactor-dependent protein refolding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in heat shock-mediated polytene chromosome puffing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein refolding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in response to heat	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to heat	NAS Non-traceable Author Statement more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to unfolded protein	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: heat shock protein 70 Ba

Names: 70 kDa heat shock protein, cytosolic A 3; 87C locus; CG31449-PA; Heat-shock-protein-70Ba; Hsp70Ba-PA; heat shock 70; heat shock protein 70BA; heat-shock protein 70; hsp70 87C; protein 70

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

12465453..12467776 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_169469.2 → NP_731716.1 heat shock protein 70 Ba [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731716.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8INI8

UniProtKB/TrEMBL

C7LA76, F3YDI6

Related

FBpp0082147, FBtr0082679

Conserved Domains (2) summary

cd10233
Location:3 → 379

HSPA1-2_6-8-like_NBD; Nucleotide-binding domain of HSPA1-A, -B, -L, HSPA-2, -6, -7, -8, and similar proteins

PTZ00009
Location:2 → 641

PTZ00009; heat shock 70 kDa protein; Provisional